当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Clinical, biochemical and genetical resistance to clopidogrel in a patient with the recurrent coronary stent thrombosis--a case report and review of the literature.

Clinical, biochemical and genetical resistance to clopidogrel in a patient with the recurrent coronary stent thrombosis--a case report and review of the literature.

Abstract：

:The in-stent thrombosis is considered as a serious complication of percutaneous coronary intervention. The impaired response to the antiplatelet therapy may play an important role in this crucial problem. Recurrent thrombosis can be explained by genetic background. Because the phenomenon of clopidogrel resistance is associated with an increased risk of recurrent cardiovascular events, genetic variants of a platelet receptor P2Y(12) might be the risk factor. Although there is no test recommended to assess the response to the antiplatelet therapy, the presented case suggests platelet function analysis should be undertaken in patients with recurrent stent thrombosis.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Glowczynska R,Malek LA,Spiewak M,Filipiak KJ,Grabowski M,Kisiel B,Kochman J,Kostrzewa G,Ploski R,Opolski G

doi

10.1016/j.ijcard.2005.11.048

subject

Has Abstract

pub_date

2006-08-10 00:00:00

pages

326-8

issue

2

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(05)01433-6

journal_volume

111

pub_type

信件

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