Abstract：
BACKGROUND:Syncope has been associated with increased risk of sudden cardiac arrest (SCA) in specific patient populations, such as hypertrophic cardiomyopathy, heart failure, and long QT syndrome, but data are lacking on the risk of SCA associated with syncope among patients with coronary artery disease (CAD), the most common cause of SCA. We investigated this association among CAD patients in the community. METHODS:All cases of SCA due to CAD were prospectively identified in Portland, Oregon (population approximately 1 million) as part of the Oregon Sudden Unexpected Death Study 2002-2015, and compared to geographical controls. Detailed clinical information including history of syncope and cardiac investigations was obtained from medical records. RESULTS:2119 SCA cases (68.4±13.8years, 66.9% male) and 746 controls (66.7±11.7years, 67.0% male) were included in the analysis. 143 (6.8%) of cases had documented syncope prior to the SCA. SCA cases with syncope were >5years older and had more comorbidities than other SCA cases. After adjusting for clinical factors and left ventricular ejection fraction (LVEF), syncope was associated with increased risk of SCA (OR 2.8; 95%CI 1.68-4.85). When analysis was restricted to subjects with LVEF ≥50%, the risk of SCA associated with syncope remained significantly elevated (adjusted OR 3.1; 95%CI 1.68-5.79). CONCLUSIONS:Syncope was associated with increased risk of SCA in CAD patients even with preserved LV function. These findings suggest a role for this clinical marker among patients with CAD and normal LVEF, a large sub-group without any current means of SCA risk stratification.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Aro AL,Rusinaru C,Uy-Evanado A,Reinier K,Phan D,Gunson K,Jui J,Chugh SSdoi
10.1016/j.ijcard.2016.12.021subject
Has Abstractpub_date
2017-03-15 00:00:00pages
26-30eissn
0167-5273issn
1874-1754pii
S0167-5273(16)32231-8journal_volume
231pub_type
杂志文章,多中心研究abstract：BACKGROUND:Obesity and metabolic syndrome are important risk factors for atrial fibrillation. High plasma concentrations of monounsaturated fatty acids, including oleic acid (OLA), are frequently noted in obese individuals and patients with metabolic syndrome. However, it is not clear whether monounsaturated fatty acid...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.07.004
更新日期：2014-09-01 00:00:00
abstract：:We studied hypertrophic patterns in the electrocardiograms of 60 Nigerian hypertensives. Thirty were in heart failure and 30 without failure (matched for age and sex). Combined left ventricular and left atrial hypertrophy was the commonest finding occurring in 58.3%, followed by left ventricular hypertrophy alone in 3...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90129-d
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Several studies have shown that mild hypothermia (32-34°C) markedly mitigates brain damage after cardiac arrest (CA). This study aimed to compare the efficacy of the non-invasive cooling device Hilotherm Clinic (Hilotherm GmbH, Germany) with conventional cooling to induce and maintain mild hypothermia in pat...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2010.07.026
更新日期：2011-11-03 00:00:00
abstract：:Only rarely have serious side effects been reported with the use of intravenous dipyridamole. We describe two cases of severe bradycardia, of which one led to asystole, in patients undergoing dipyridamole-thallium studies. The association between beta blocker therapy and the seven reported cases of asystole with dipyr...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(93)90108-s
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Inflammation contributes to the pathogenesis of disease associated with the left ventricle (LV); yet, our understanding of the effect of inflammation on the right ventricle (RV) is quite limited. METHODS AND RESULTS:The relationships of C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinoge...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2013.06.028
更新日期：2013-10-09 00:00:00
abstract：:We evaluated the effects of bepridil hydrochloride, a long-acting calcium antagonist, on the electrocardiogram of 13 men with exertional angina. The drug decreased sinus rate (P = 0.01), increased the QT (P less than 0.001) and QTc interval (P less than 0.001), and produced T-wave changes in each patient. ...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0167-5273(84)90191-8
更新日期：1984-09-01 00:00:00
abstract：BACKGROUND:The mitochondrial permeability transition pore (mPTP) plays an important role in ischemia-reperfusion in normotensive animals. Our study aims to define their participation in the ischemic preconditioning (IP) in hypertrophied hearts and to assess the role played by NO and mitochondrial ATP-dependent K channe...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2011.10.103
更新日期：2013-06-05 00:00:00
abstract：OBJECTIVE:To determine the frequency of cardiac alterations in necropsies of AIDS patients in pre-HAART era and better understand the pathogenesis of HIV-related cardiomyopathy. DESIGN:Retrospective study of 94 complete necropsies. METHOD:Macroscopic, histopathologic (histochemical, immunohistochemical and in situ hy...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2007.10.057
更新日期：2009-02-06 00:00:00
abstract：BACKGROUND:Metabolic syndrome (MetS) is associated with a substantially increased risk for cardiovascular disease and diabetes. We examined the contribution of length of residence, socioeconomic position and lifestyle-related factors to the differences in the prevalence of MetS among migrants compared with Finns. METH...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2017.01.051
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:The majority of the protocols for cardiomyocyte differentiation of MSC use 5-azacytidine as an inducer. As transforming growth factor β1 and 5-azacytidine share similar target signaling pathways, we examined whether transforming growth factor β1 can play a role in cardiac differentiation process in human mes...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2011.08.003
更新日期：2013-02-10 00:00:00
abstract：OBJECTIVE:Oxidative stress seems to play a role in impairing flow-mediated dilation (FMD) in patients with peripheral artery disease (PAD) but the underlying mechanism is still undefined. We evaluated whether NOX2, the catalytic core of NADPH oxidase, the most important producer of reactive oxidant species (ROS), is im...
journal_title：International journal of cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ijcard.2012.01.069
更新日期：2013-04-30 00:00:00
abstract：:Neurocardiogenic dysfunction is described in acute neurological injury. We report a case of ischemic stroke mimicking acute myocardial infarction. ...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2005.03.069
更新日期：2006-04-28 00:00:00
abstract：BACKGROUND:The pathogenesis of aortic valve stenosis may involve inflammation and we have previously demonstrated Chlamydophila pneumoniae (C. pneumoniae) DNA in stenotic aortic heart valves. Dissemination of these bacteria is probably mediated by alveolar macrophages. Bacterial DNA alone does not indicate whether the ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2009.01.052
更新日期：2010-08-06 00:00:00
abstract：:A large family with a new phenotype of conduction system disease including heart blocks and preexcitation associated with hypertrophic cardiomyopathy and transmitted in an autosomal dominant pattern is described. ...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2006.12.050
更新日期：2008-04-25 00:00:00
abstract：OBJECTIVE:We determined the occurrence of presenting symptoms in patients with different sites of acute myocardial infarction after controlling for age and conventional risk factors. METHODS:Hospital-based study of patients hospitalized because of first anterior (n=731), inferior (n=719) and lateral (n=96) infarction ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(00)00414-9
更新日期：2001-02-01 00:00:00
abstract：:Changes of both central hemodynamics and peripheral circulation in non-exercising muscle were investigated in 17 patients after successful orthotopic heart transplantation during moderate supine isotonic leg-exercise. Changes of peripheral circulation were measured in 14 healthy controls. The cardiac output rose from ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(94)90288-7
更新日期：1994-05-01 00:00:00
abstract：:The negative inotropism, myocardial dilatation and cytotoxicity in inflammatory heart disorders may be due to increased generation of nitric oxide (NO) by immunological induction of a high output NO pathway. This short review discusses the initial experiments which lead to this hypothesis, and evaluates data that this...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/0167-5273(95)02386-b
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:Melatonin, a lypophylic antioxidant, was reported to be low in patients suffering from myocardial infarction, a disease due to coronary atherosclerosis associated with increased reactive oxygen species. Studies carried out till now have shown association of either melatonin or another antioxidant Cu/Zn SOD i...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2009.03.004
更新日期：2010-10-08 00:00:00
abstract：:We have previously reported that serum and/or urinary human heart-type cytoplasmic fatty acid-binding protein (HH-FABPc) can be used as an early indicator of myocardial injury (Clin Biochem 1991; 24: 195-201). To confirm the usefulness of HH-FABPc as an early diagnostic indicator of acute myocardial infarction (AMI), ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(93)90117-y
更新日期：1993-10-01 00:00:00
abstract：BACKGROUND:To investigate the contribution of individual and population factors to Coronary Heart Disease (CHD) mortality rates in Ireland between 2000 and 2015. METHODS:The Irish IMPACT CHD model was utilized with CHD Deaths Prevented or Postponed (DPPs) as outcome. RESULTS:CHD mortality rates in Ireland in those ag...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.03.067
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVES:To study coronary heart disease (CHD) incidence versus other cause of death using the cumulative incidence function and the competing risks procedures to disentangle the differential role of risk factors for different end-points. MATERIAL AND METHODS:We compared standard Cox and Fine-Gray models among 1677 ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.05.043
更新日期：2016-09-15 00:00:00
abstract：BACKGROUND:In patients with chronic heart failure (CHF) increasing levels of total serum cholesterol are associated with improved survival - while statin usage is not. The impact of statin treatment on the "reverse epidemiology" of cholesterol is unclear. METHODS:2992 consecutive patients with non-ischemic CHF due to ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.03.028
更新日期：2017-07-01 00:00:00
abstract：:To establish a noninvasive diagnostic method for early assessment of cardiac involvement in Kawasaki disease (KD), 28 children with KD were included in this study. Two-dimensional echocardiography (2D-Echo) to detect the aneurysms of coronary arteries (CA), as well as rest and dipyridamole-stress technetium-99m tetrof...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(02)00525-9
更新日期：2003-07-01 00:00:00
abstract：:The effects of 5 and 10 mg of amlodipine and of placebo were compared in 21 patients with stable angina pectoris and multivessel coronary artery disease. The blind comparison was performed by means of bicycle ergometry and stress echocardiography using esophageal stimulation of the left heart atrium. All patients subs...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章
doi：10.1016/0167-5273(92)90137-r
更新日期：1992-10-01 00:00:00
abstract：:Isolated subvalvular pulmonary stenosis (ISPS) is a rare condition, and it is often accompanied by hypertrophic cardiomyopathy. However, diagnosis of ISPS is obscure because of difficulty in comprehension of three-dimensional cardiac anatomy. Whole-heart magnetic resonance imaging (MRI) is a new, totally non-invasive ...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.05.106
更新日期：2009-01-09 00:00:00
abstract：BACKGROUND:Nicorandil is able to protect the cardiomyocytes from ischemic damage, but clear benefits of nicorandil in all-cause mortality and cardiovascular events were not consistently reported in patients with ischemic heart disease (IHD). MATERIALS AND RESULTS:Cochrane, PubMed, EMBASE, CBM, CNKI and Wangfang databa...
journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ijcard.2014.07.007
更新日期：2014-10-20 00:00:00
abstract：:We have studied, by light and electron microscopy, left ventricular endomyocardial biopsy specimens from 18 African patients (14 men) with idiopathic dilated cardiomyopathy in Nairobi. Nine patients (50%) had evidence of healing myocarditis, that is the presence of a mild inflammatory cell infiltration within the myoc...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(93)90156-b
更新日期：1993-09-01 00:00:00
abstract：:A case is described where severe hypophosphataemia was induced by a widely used protocol for glucose-insulin-potassium (GIK) infusion. Hypophosphataemia was found to be a universal sequel to the use of this infusion. A new regimen for administering this agent was designed, and shown to lack the potentially serious sid...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(88)90051-4
更新日期：1988-03-01 00:00:00
abstract：:The search for a genuine thought in ancient times makes medical archeology part of our contemporary knowledge, not to say a patrimony to be harbored. A Roman encyclopedia is a compilation of the prevailing knowledge of scientific and medical matters at the time. In this paper an original Roman prescription for a speci...
journal_title：International journal of cardiology
pub_type： 传,历史文章,信件
doi：10.1016/j.ijcard.2006.11.049
更新日期：2007-11-15 00:00:00
abstract：:Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates in industrialized and developing countries. Animal models are interesting to investigate the causality, but also underlying mechanisms and potential treatments of human valvular diseases. Recently, animal models of...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2012.03.065
更新日期：2013-05-25 00:00:00
