Effect of prostacyclin on coronary occlusion in acute myocardial infarction.

Abstract:

:Prostacyclin is a powerful inhibitor of platelet aggregation and induces relaxation of vascular smooth muscle. We have studied the coronary effects of high local concentrations of prostacyclin in 17 patients during the early stages of acute myocardial infarction. We infused graded concentrations of intracoronary prostacyclin and compared the effects to those of intracoronary isosorbide dinitrate before and after an intracoronary infusion of streptokinase. Considerable dilation of the infarct-related stenosis may follow local infusions of prostacyclin in some patients. In general, however, dilation of the infarct-related stenosis or coronary recanalization did not result from infusion of prostacyclin.

journal_name

Int J Cardiol

authors

Hackett D,Davies G,Maseri A

doi

10.1016/0167-5273(90)90247-3

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

53-7

issue

1

eissn

0167-5273

issn

1874-1754

pii

0167-5273(90)90247-3

journal_volume

26

pub_type

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