Abstract:
BACKGROUND:Heparin is an important medication in the treatment of patients with unstable angina pectoris. We designed an observational study to compare the effects of standard heparin (SH) with low molecular weight heparin (LMWH) on vascular endothelial growth factor (VEGF) levels in patients undergoing coronary artery bypass grafting (CABG). METHODS:Thirty-two patients with unstable angina pectoris undergoing CABG were prospectively categorized into two groups according to the type of heparin administration before surgery. VEGF levels determined by enzyme linked immunosorbent assay (ELISA) were compared between the two groups' blood samples obtained before the surgery and pericardial fluid after pericardial opening. RESULTS:There was no difference in preoperative characteristics between the two groups. Serum VEGF levels were similar (P=0.3) in patients treated by SH (85+/-55 pg/ml) compared to those treated with LMWH (105+/-64 pg/ml). VEGF levels in the pericardial fluid were significantly raised (P<0.0001) in patients of LMWH group (36+/-13 pg/ml) compared to SH group (13+/-6 pg/ml). A good correlation was observed between VEGF in the serum and platelet count in both SH group (r=0.8) and LMWH group (r=0.7). CONCLUSIONS:Local response of the ischemic myocardium, as expressed by VEGF levels, differs in patients treated with SH compared to patients treated with LMWH. VEGF levels in pericardial fluid of patients receiving LMWH were 2-3-folds higher than patients in SH group.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Gerrah R,Tshori S,Gilon Ddoi
10.1016/j.ijcard.2003.03.022subject
Has Abstractpub_date
2004-04-01 00:00:00pages
193-6issue
2-3eissn
0167-5273issn
1874-1754pii
S0167527303003784journal_volume
94pub_type
杂志文章abstract::The effects of 5 and 10 mg of amlodipine and of placebo were compared in 21 patients with stable angina pectoris and multivessel coronary artery disease. The blind comparison was performed by means of bicycle ergometry and stress echocardiography using esophageal stimulation of the left heart atrium. All patients subs...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2011.02.039
更新日期:2012-08-23 00:00:00
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pub_type: 杂志文章
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更新日期:2010-10-08 00:00:00
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pub_type: 杂志文章
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更新日期:2016-09-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 社论
doi:
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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pub_type: 共识发展会议,杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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更新日期:2015-01-20 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-02-15 00:00:00
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pub_type: 杂志文章
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更新日期:2016-07-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2005-09-01 00:00:00
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pub_type: 信件
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更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2011-05-05 00:00:00