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Closure of atrial septal defect in the adult. Cardiac remodeling is an early event.

Abstract：

BACKGROUND:Study aimed to describe the extent and the temporal profile of cardiac remodeling after atrial septal defect closure in the adult. METHODS:Prospective and longitudinal echocardiographic assessment of right and left heart size before and after (1 day-1 week/1/4/12 months) surgical or catheter-based atrial septal closure in 39 adults (age 54+/-15 years). RESULTS:Right ventricular and atrial sizes were markedly reduced, left ventricular size increased and left atrial size remained unchanged after closure. Older age and a history of atrial fibrillation reduced the potential to normalize right and left atrial size after closure. The greater part of the changes occurred very early, in the 1st day/1st week. From then on the speed of change gradually diminished and after 4 months no important changes were observed. The mode of closure did not influence the degree or the pace of the remodeling. CONCLUSION:Cardiac remodeling after atrial septal closure in the adult is a common and early event that seems by and large completed within the first half year after closure. The ventricles seem to have a higher capacity of remodeling than the atria in this setting. The mode of closure does not seem to significantly impact remodeling.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Thilén U,Persson S

doi

10.1016/j.ijcard.2005.05.042

subject

Has Abstract

pub_date

2006-04-14 00:00:00

pages

370-5

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(05)00748-5

journal_volume

108

pub_type

杂志文章

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