Abstract:
BACKGROUND:Angiopoietin-2 (Angpt2) has been implicated in the mediation and regulation of angiogenesis and inflammation which are believed to be critical mechanisms in the pathogenesis of both abdominal aortic aneurysm (AAA) and cardiovascular events. The aim of this study was to assess whether serum Angpt2 was associated with the prevalence of AAA and the occurrence of cardiovascular mortality in older men. METHODS:A cohort of 997 elderly men was recruited in 1996-99. Aortic ultrasound identified an AAA in 308 (31%). In 2001-04, blood was collected and serum Angpt2 later measured by immunoassay. The association of Angpt2 with AAA was assessed using multiple regression analysis. All men were followed by means of the Western Australia Data Linkage System until July 31st 2009. The association of Angpt2 with cardiovascular mortality was assessed using Cox proportional hazard analysis. RESULTS:Median serum Angpt2 was significantly higher (3.16 ng/ml, inter-quartile range 2.51-4.54) in men with AAA compared with men without AAA (2.70 ng/ml, inter-quartile range 2.03-3.72; p<0.001). After adjusting for cardiovascular risk factors, men with serum Angpt2 in the highest quartile (>3.95 ng/ml) had a 2.57-fold (95% CI 1.66-3.97, p<0.001) increased odds of AAA and a 4.12-fold (95% CI 1.90-8.94, p<0.001) increased relative risk of cardiovascular mortality compared to men with serum Angpt2 in the lowest quartile (<2.13 ng/ml). CONCLUSIONS:Serum Angpt2 is elevated in men with AAA and associated with an increased risk of cardiovascular mortality in older men.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Golledge J,Clancy P,Yeap BB,Hankey GJ,Norman PEdoi
10.1016/j.ijcard.2012.03.120subject
Has Abstractpub_date
2013-08-20 00:00:00pages
1159-63issue
4eissn
0167-5273issn
1874-1754pii
S0167-5273(12)00327-0journal_volume
167pub_type
杂志文章,随机对照试验abstract::Previous reports have yielded contradictory conclusions regarding the safety of digoxin therapy in patients with acute myocardial infarction. The purpose of our study was to determine whether digoxin therapy is associated with increased mortality in patients with chronic coronary artery disease. We analyzed data from ...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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