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Pathophysiology of acute coronary syndromes in the elderly.

Abstract：

:Elderly patients represent an important proportion of the acute coronary syndrome (ACS) population. Furthermore, this group of ACS patients is continuously growing because of the progressive ageing of the population. The ageing process implies marked changes in patient physiology that directly impact in their risk. However, there is a differential distribution in the risk of elderly patients, revealing the existence of a discrepancy between the chronological and the "biological age". This discrepancy has highlighted the need of performing individual risk assessment in order to identify those patients at higher risk. In addition, the lack of representation of elderly patients in clinical trials leads to the underutilization of evidence-based therapies in this group of patients. All these factors influence not only the high prevalence of ACS presentation in the elderly but also their worse prognosis after suffering an ischaemic event. Herein we will explore the pathophysiological mechanisms behind the age-related changes at the vascular and the cardiac level that explain the high risk of elderly subjects of suffering ACS and their worse prognosis.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Badimon L,Bugiardini R,Cubedo J

doi

10.1016/j.ijcard.2016.07.205

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

1105-1109

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)31600-X

journal_volume

222

pub_type

杂志文章,评审

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