当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Doxazosin GITS versus standard doxazosin in mild to moderate hypertension.

Doxazosin GITS versus standard doxazosin in mild to moderate hypertension.

Abstract：

BACKGROUND:The selective alpha 1-adrenoceptor antagonist doxazosin in both standard formulation and gastrointestinal therapeutic system (GITS) controlled-release formulation is effective for hypertension without having a negative impact on serum lipids. This study was designed to compare the relative efficacy of these two formulations of doxazosin on clinic and ambulatory blood pressure and serum lipids in patients with mild to moderate hypertension. METHODS:Hypertensive patients aged 18-70 years (n = 335) were evaluated in a multi-center prospective randomized study. Following a 2-week placebo run-in phase, patients were randomized to receive doxazosin 2 or 4 mg, with dose titration, or doxazosin GITS 4 mg, no dose titration, for 9 weeks. RESULTS:Both doxazosin formulations reduced clinic diastolic and systolic blood pressure from baseline (P < 0.0001). Doxazosin GITS and doxazosin 4 mg had similar blood pressure-lowering effects. Doxazosin GITS reduced sitting diastolic and systolic blood pressure compared with doxazosin 2 mg (P < 0.01 for both). A greater proportion of the doxazosin GITS group reached goal blood pressure (< or = 140/90 mm Hg) after 9 weeks compared with the doxazosin 2-mg group. All doses of doxazosin reduced 24-h and daytime (7:00 am to 10:00 pm) ambulatory blood pressure from baseline (all P < 0.01). Doxazosin GITS significantly reduced nighttime (10:00 pm to 7:00 am) ambulatory blood pressure from baseline. A neutral effect on serum lipids was observed with doxazosin. CONCLUSIONS:Doxazosin GITS and doxazosin were effective in reducing clinic and ambulatory blood pressure. The GITS formulation reduced the need for dose titration. Both doxazosin formulations were well tolerated.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Calvo C,Gil-Extremera B,Gomez-Fernández P,Masramon X,Pueyo C,Armada B

doi

10.1016/j.ijcard.2004.07.005

subject

Has Abstract

pub_date

2005-05-11 00:00:00

pages

97-104

issue

1

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(04)00640-0

journal_volume

101

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Atrioventricular septal defect: From embryonic development to long-term follow-up.

    abstract：:Atrioventricular septal defect (AVSD) covers a spectrum of heart anomalies with a common atrioventricular connection and has an incidence of 4-5.3 per 10.000 live births. About half of the AVSDs occur in patient with Down syndrome. This review provides a bench to bedside overview of AVSD. Developmental aspects, nomenc...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2015.09.081

    authors： Calkoen EE,Hazekamp MG,Blom NA,Elders BB,Gittenberger-de Groot AC,Haak MC,Bartelings MM,Roest AA,Jongbloed MR

    更新日期：2016-01-01 00:00:00

  • Abnormal sinoatrial node development resulting from disturbed vascular endothelial growth factor signaling.

    abstract：BACKGROUND:Sinus node dysfunction is frequently observed in patients with congenital heart disease (CHD). Variants in the Vascular Endothelial Growth Factor-A (VEGF) pathway are associated with CHD. In Vegf(120/120) mice, over-expressing VEGF120, a reduced sinoatrial node (SAN) volume was suggested. Aim of the study is...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.12.006

    authors： Calkoen EE,Vicente-Steijn R,Hahurij ND,van Munsteren CJ,Roest AA,DeRuiter MC,Steendijk P,Schalij MJ,Gittenberger-de Groot AC,Blom NA,Jongbloed MR

    更新日期：2015-03-15 00:00:00

  • Quibus cor palpitet: hyena cor.

    abstract：:The search for a genuine thought in ancient times makes medical archeology part of our contemporary knowledge, not to say a patrimony to be harbored. A Roman encyclopedia is a compilation of the prevailing knowledge of scientific and medical matters at the time. In this paper an original Roman prescription for a speci...

    journal_title：International journal of cardiology

    pub_type： 传,历史文章,信件

    doi：10.1016/j.ijcard.2006.11.049

    authors： van Tellingen C

    更新日期：2007-11-15 00:00:00

  • Human heart-type cytoplasmic fatty acid-binding protein in serum and urine during hyperacute myocardial infarction.

    abstract：:We have previously reported that serum and/or urinary human heart-type cytoplasmic fatty acid-binding protein (HH-FABPc) can be used as an early indicator of myocardial injury (Clin Biochem 1991; 24: 195-201). To confirm the usefulness of HH-FABPc as an early diagnostic indicator of acute myocardial infarction (AMI), ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(93)90117-y

    authors： Tsuji R,Tanaka T,Sohmiya K,Hirota Y,Yoshimoto K,Kinoshita K,Kusaka Y,Kawamura K,Morita H,Abe S

    更新日期：1993-10-01 00:00:00

  • Comparison of resting distal to aortic coronary pressure with angiography-based quantitative flow ratio.

    abstract：BACKGROUND:Quantitative flow ratio (QFR) is a novel, adenosine-free method for functional coronary lesion interrogation, which is based on 3-dimensional quantitative coronary angiography and computational algorithms. Data on QFR in all-comer patients with intermediate coronary lesions are scarce, and the diagnostic per...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.11.093

    authors： Stähli BE,Erbay A,Steiner J,Klotsche J,Mochmann HC,Skurk C,Lauten A,Landmesser U,Leistner DM

    更新日期：2019-03-15 00:00:00

  • Impact of Fetuin-A on progression of calcific aortic valve stenosis - The COFRASA - GENERAC study.

    abstract：BACKGROUND:Aortic stenosis (AS) is an active disease, but the determinants of AS progression remain largely unknown. Low levels of Fetuin-A, a powerful inhibitor of ectopic calcification, have been linked to ectopic calcium tissue deposition but its role in AS progression has not been clearly evaluated. METHODS:In our...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.03.070

    authors： Kubota N,Testuz A,Boutten A,Robert T,Codogno I,Duval X,Tubiana S,Hekimian G,Arangalage D,Cimadevilla C,Kerneis C,Vahanian A,Messika-Zeitoun D

    更新日期：2018-08-15 00:00:00

  • Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9.

    abstract：BACKGROUND:Alterations in coronary vasomotor tone may participate in the pathogenesis of acute myocardial infarction (AMI). Vascular ATP-sensitive K(+) (KATP) channels, formed by Kir6.x/SUR2B, are key regulators of coronary tone and mutations in cardiac (Kir6.2/SUR2A) KATP channels result in heart disease. Here we expl...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2013.04.210

    authors： Smith KJ,Chadburn AJ,Adomaviciene A,Minoretti P,Vignali L,Emanuele E,Tammaro P

    更新日期：2013-10-09 00:00:00

  • Effectiveness of subcutaneous implantable cardioverter-defibrillator testing in patients with hypertrophic cardiomyopathy.

    abstract：BACKGROUND:Subcutaneous ICD (S-ICD) is a promising option for Hypertrophic Cardiomyopathy (HCM) patients at risk of Sudden Cardiac Death (SCD). However, its effectiveness in terminating ventricular arrhythmias in HCM is yet unresolved. METHODS:Consecutive HCM patients referred for S-ICD implantation were prospectively...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.12.187

    authors： Maurizi N,Tanini I,Olivotto I,Amendola E,Limongelli G,Losi MA,Allocca G,Perego GB,Pieragnoli P,Ricciardi G,De Filippo P,Ferrari P,Quarta G,Viani S,Rapacciuolo A,Bongiorni MG,Cecchi F

    更新日期：2017-03-15 00:00:00

  • Impact of aspirin on the prognosis in patients with coronary spasm without significant atherosclerotic stenosis.

    abstract：BACKGROUND:Coronary spasm is one of the mechanisms of myocardial infarction with nonobstructive coronary arteries (MINOCA). The aim of this study was to investigate the effects of aspirin on future cardiovascular events in patients with coronary vasospastic angina (VSA) with non-significant atherosclerotic stenosis. M...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.06.157

    authors： Ishii M,Kaikita K,Sato K,Yamanaga K,Miyazaki T,Akasaka T,Tabata N,Arima Y,Sueta D,Sakamoto K,Yamamoto E,Tsujita K,Yamamuro M,Kojima S,Soejima H,Hokimoto S,Matsui K,Ogawa H

    更新日期：2016-10-01 00:00:00

  • Early detection of cardiac dysfunction in patients with anorexia nervosa by tissue Doppler imaging.

    abstract：BACKGROUND:Cardiac damage is a major complication of chronic starvation. The aim of this study was to evaluate the changes of left ventricular function in patients with anorexia nervosa by means of pulsed tissue Doppler imaging. METHODS:A total of 20 females (age 22.4+/-4.3 years) with overt anorexia nervosa, 20 match...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2004.03.006

    authors： Galetta F,Franzoni F,Cupisti A,Morelli E,Santoro G,Pentimone F

    更新日期：2005-05-11 00:00:00

  • Effect of duration of data averaging interval on reported peak VO2 in patients with heart failure.

    abstract：AIM:To describe the effect of the duration of the data averaging interval on the calculated peak oxygen uptake (VO2) reported from a symptom-limited maximal exercise test in patients with heart failure. METHODS:Maximal exercise test results from 275 patients diagnosed with stable heart failure due to left ventricular ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.12.174

    authors： Smart NA,Jeffriess L,Giallauria F,Vigorito C,Vitelli A,Maresca L,Ehrman JK,Keteyian SJ,Brawner CA

    更新日期：2015-03-01 00:00:00

  • The association of low plasma testosterone level with coronary artery disease in Chinese men.

    abstract：:The incidence rate and mortality of coronary heart disease (CHD) is obviously higher in men than in women, which may be related to the influence of plasma lipoprotein metabolism by endogenous sex hormones. We determined plasma testosterone (TTT), estradiol, total cholesterol (TC), triglyceride (TG), high density lipop...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0167-5273(97)00295-7

    authors： Zhao SP,Li XP

    更新日期：1998-01-31 00:00:00

  • Pre-hospital cardiac arrest associated with coronary artery spasm.

    abstract：:A 37-yr-old woman with an 8-month history of chest pain, unrelated to exercise, was successfully resuscitated from out-of-hospital cardiac arrest due to ventricular fibrillation. Cardiac catheterisation revealed minor coronary artery disease. Ergometrine injection was associated with complete occlusion of the left ant...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0167-5273(93)90211-x

    authors： Weston CF,Tigg A,Griffiths BE

    更新日期：1993-01-01 00:00:00

  • The natural history of guidelines: the case of aortopathy related to bicuspid aortic valves.

    abstract：:Clinical guidelines represent statements that seek to synthesize the best evidence to guide a course of action to improve health outcomes and more cost-effective use of resources. However, even when the evidence is not definitive, comprehensive documents are still needed to guide clinical decision-making. In these cir...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2015.06.059

    authors： Hardikar AA,Marwick TH

    更新日期：2015-11-15 00:00:00

  • A case of takotsubo cardiomyopathy associated with Kounis syndrome.

    abstract：:A sixty-five-year old female, with a past history of variant angina and asthma, collapsed after complaining of chest pain and regained spontaneous circulation by resuscitation. An electrocardiograph showed a QS pattern on the precordial leads and sonography revealed a takotsubo cardiomyopathy-like movement. During ind...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.08.022

    authors： Yanagawa Y,Nishi K,Tomiharu N,Kawaguchi T

    更新日期：2009-02-20 00:00:00

  • Multinational evaluation of the interpretability of the iterative method of optimisation of AV delay for CRT.

    abstract：BACKGROUND:AV delay optimisation of biventricular pacing devices (cardiac resynchronisation therapy, CRT) is performed in trials and recommended by current guidelines. The Doppler echocardiographic iterative method is the most commonly recommended. Yet whether it can be executed reliably has never been tested formally....

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.09.097

    authors： Raphael CE,Kyriacou A,Jones S,Pabari P,Cole G,Baruah R,Hughes AD,Francis DP

    更新日期：2013-09-20 00:00:00

  • Primary fibrosarcoma of the heart presenting as obstruction at the tricuspid valve: diagnosis by cross-sectional echocardiography.

    abstract：:We report a case of primary fibrosarcoma of the heart which presented with features of obstruction to the tricuspid valve and superior caval vein. It was correctly diagnosed by cross-sectional echocardiography. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(89)90309-4

    authors： Sethi KK,Nair M,Khanna SK

    更新日期：1989-08-01 00:00:00

  • Incidence and impact of renal dysfunction on clinical outcomes after transcatheter aortic valve implantation.

    abstract：BACKGROUND:The impact of baseline renal dysfunction on early and late clinical outcomes after transcatheter aortic valve implantation (TAVI) remains to be defined. METHODS:927 patients included in the prospective Bern TAVI registry were classified on the basis of the baseline estimated glomerular filtration rate (eGFR...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.09.201

    authors： Franzone A,Stortecky S,Pilgrim T,Asami M,Lanz J,Heg D,Langhammer B,Piccolo R,Lee JKT,Praz F,Räber L,Valgimigli M,Roost E,Windecker S

    更新日期：2018-01-01 00:00:00

  • Diagnostic and prognostic implications using age- and gender-specific cut-offs for high-sensitivity cardiac troponin T - Sub-analysis from the TRAPID-AMI study.

    abstract：OBJECTIVES:To evaluate the impact of age- and gender-specific cut-offs for high-sensitivity cardiac troponin T (hs-cTnT) compared to the general 99th percentile hs-cTnT cut-off on diagnosis and prognosis of acute myocardial infarction (AMI). METHODS:1282 unselected patients presenting to the emergency department with ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2016.01.213

    authors： Mueller-Hennessen M,Lindahl B,Giannitsis E,Biener M,Vafaie M,deFilippi CR,Christ M,Santalo-Bel M,Panteghini M,Plebani M,Verschuren F,Jernberg T,French JK,Christenson RH,Body R,McCord J,Dilba P,Katus HA,Mueller C,TRA

    更新日期：2016-04-15 00:00:00

  • Prognostic impact of global left ventricular hemodynamic afterload in severe aortic stenosis with preserved ejection fraction.

    abstract：INTRODUCTION:Global left ventricular (LV) afterload as assessed by valvulo-arterial impedance (Zva), may be an independent predictor of mortality in patients with severe aortic stenosis (AS) and preserved LV ejection fraction (LVEF). However, its quantification using echocardiography may be subject to error measurement...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.11.180

    authors： Magne J,Mohty D,Boulogne C,Deltreuil M,Cassat C,Echahidi N,Laskar M,Lacroix P,Virot P,Aboyans V

    更新日期：2015-02-01 00:00:00

  • 2D-speckle tracking right ventricular strain to assess right ventricular systolic function in systolic heart failure. Analysis of the right ventricular free and posterolateral walls.

    abstract：BACKGROUND:Right ventricular (RV) systolic function is a powerful prognostic factor in patients with systolic heart failure. The accurate estimation of RV function remains difficult. The aim of the study was to determine the diagnostic accuracy of 2D-speckle tracking RV strain in patients with systolic heart failure, a...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.07.077

    authors： Mouton S,Ridon H,Fertin M,Pentiah AD,Goémine C,Petyt G,Lamblin N,Coisne A,Foucher-Hossein C,Montaigne D,de Groote P

    更新日期：2017-10-15 00:00:00

  • Extent of lung involvement over severity of cardiac disease for the prediction of adverse outcome in COVID-19 patients with cardiovascular disease.

    abstract：BACKGROUND:Aim of the present study was to assess if the presence of high cardiovascular risk, left ventricle systolic dysfunction or elevated BNP or Troponin are able to independently predict the outcome of patients with known cardiac disease and COVID-19 pneumonia. METHODS AND RESULTS:From March 7th to April 28th, f...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.10.006

    authors： Andreini D,Conte E,Mushtaq S,Gigante C,Mancini ME,Annoni A,Stefanini G,Agalbato C,Cosentino N,Pontone G,Assanelli E,Pepi M

    更新日期：2021-01-15 00:00:00

  • Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes.

    abstract：:To test the hypothesis that neurotrophins might undergo significant changes in acute coronary syndrome (ACS), NGF and BDNF levels in sera of patients suffering of ACS and in control subjects were measured by enzyme-linked immunosorbent assay (ELISA). Plasma concentrations of glucose, total cholesterol, triglycerides, ...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2004.10.041

    authors： Manni L,Nikolova V,Vyagova D,Chaldakov GN,Aloe L

    更新日期：2005-06-22 00:00:00

  • Retrograde percutaneous recanalization of coronary chronic total occlusions: outcomes from 17 patients.

    abstract：:Given their suboptimal success rates, coronary chronic total occlusions (CTO) represent one of the last challenges of percutaneous coronary intervention (PCI). Among several novel techniques, the retrograde approach is one of the most promising, but it is still incompletely described. We report our 5-year experience i...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.07.144

    authors： Biondi-Zoccai GG,Bollati M,Moretti C,Sciuto F,Omedé P,Lombardi P,Previ GP,Sheiban I

    更新日期：2008-10-30 00:00:00

  • Clinical outcome of patients undergoing multivessel coronary stent implantation.

    abstract：OBJECTIVES:To evaluate the outcome of patients undergoing multivessel coronary stent implantation. BACKGROUND:Percutaneous transluminal coronary angioplasty has been shown to be an effective treatment for multivessel coronary artery disease, although the need for repeat revascularization continues to be a limitation. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(97)00333-1

    authors： Mathew V,Rihal CS,Berger PB,Bell MR,Garratt KN,Holmes R Jr

    更新日期：1998-03-13 00:00:00

  • Acquired noncompaction in Duchenne muscular dystrophy.

    abstract：:Acquired left ventricular hypertrabeculation/noncompaction (LVHT) is rare and has been described in patients with mitochondriopathy, Barth syndrome, and Becker muscular dystrophy. Here we report acquired LVHT in a 28-year-old man with Duchenne muscular dystrophy who required non-invasive, positive-pressure ventilation...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2005.01.018

    authors： Finsterer J,Stöllberger C,Gaismayer K,Janssen B

    更新日期：2006-01-26 00:00:00

  • Cardioprotective effect of atorvastatin alone or in combination with remote ischemic preconditioning on the biochemical changes induced by ischemic/reperfusion injury in a mutual prospective study with a clinical and experimental animal arm.

    abstract：BACKGROUND:Atorvastatin and remote ischemic preconditioning (RIPC) have beneficial cardiovascular protective effects. The aim of the study was to investigate possible effect of this drug alone and in combination with RIPC on the biochemical changes induced by ischemic/reperfusion injury (I/R) in a combined study with a...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.07.178

    authors： El Desoky ES,Hassan AKM,Salem SY,Fadil SA,Taha AF

    更新日期：2016-11-01 00:00:00

  • Reproducibility of the head-up tilt test results in children with vasovagal syncope.

    abstract：BACKGROUND:This prospective study aims to investigate the reproducibility of HUTT results in children with typical history of vasovagal syncope. METHODS:Between October 1996 and October 1999, 58 children with a history of typical vasovagal syncope attacks were evaluated with head up tilt test (HUTT). The table was til...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(02)00379-0

    authors： Alehan D,Uner A,Ayabakan C,Ozer S,Ozme S

    更新日期：2003-03-01 00:00:00

  • Targeting cell death in the reperfused heart: pharmacological approaches for cardioprotection.

    abstract：:During acute myocardial infarction and in the reperfused heart, loss of cardiomyocytes is mostly caused by apoptosis and necrosis. As apoptosis was considered as the only form of regulated cell death for many years, initial studies investigating cardiomyocyte cell death mainly focused on direct inhibition of apoptosis...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2012.03.055

    authors： Oerlemans MI,Koudstaal S,Chamuleau SA,de Kleijn DP,Doevendans PA,Sluijter JP

    更新日期：2013-05-25 00:00:00

  • Increased risk of cardiac death in primary hyperparathyroidism: what is a role of electrical instability?

    abstract：BACKGROUND:Increased risk of death in patients with primary hyperparathyroidism (PHPT) is referred to cardiovascular complications induced by hypercalcemia. At the moment the role of bioelectrical risk and of enhanced sympathetic activity, not related to cardiovascular complications, is unknown in PHPT patients. METHO...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2006.08.072

    authors： Curione M,Letizia C,Amato S,Di Bona S,Di Fazio F,Minisola S,Mazzuoli G,D'Erasmo E

    更新日期：2007-10-01 00:00:00