当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Abnormal sinoatrial node development resulting from disturbed vascular endothelial growth factor signaling.

Abnormal sinoatrial node development resulting from disturbed vascular endothelial growth factor signaling.

Abstract：

BACKGROUND:Sinus node dysfunction is frequently observed in patients with congenital heart disease (CHD). Variants in the Vascular Endothelial Growth Factor-A (VEGF) pathway are associated with CHD. In Vegf(120/120) mice, over-expressing VEGF120, a reduced sinoatrial node (SAN) volume was suggested. Aim of the study is to assess the effect of VEGF over-expression on SAN development and function. METHODS:Heart rate was measured in Vegf(120/120) and wildtype (WT) embryos during high frequency ultrasound studies at embryonic day (E)12.5, 14.5 and 17.5 and by optical mapping at E12.5. Morphology was studied with several antibodies. SAN volume estimations were performed, and qualitative-PCR was used to quantify expression of genes in SAN tissues of WT and Vegf(120/120) embryos. RESULTS:Heart rate was reduced in Vegf(120/120) compared with WT embryos during embryonic echocardiography (52 ± 17 versus 125 ± 31 beats per minute (bpm) at E12.5, p<0.001; 123 ± 37 vs 160 ± 29 bmp at E14.5, p=0.024; and 177 ± 30 vs 217 ± 34 bmp, at E17.5 p=0.017) and optical mapping (81 ± 5 vs 116 ± 8 bpm at E12.5; p=0.003). The SAN of mutant embryos was smaller and more vascularized, and showed increased expression of the fast conducting gap junction protein, Connexin43. CONCLUSIONS:Over-expression of VEGF120 results in reduced heart rate and a smaller, less compact and hypervascularized SAN with increased expression of Connexin43. This indicates that VEGF is necessary for normal SAN development and function.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Calkoen EE,Vicente-Steijn R,Hahurij ND,van Munsteren CJ,Roest AA,DeRuiter MC,Steendijk P,Schalij MJ,Gittenberger-de Groot AC,Blom NA,Jongbloed MR

doi

10.1016/j.ijcard.2014.12.006

subject

Has Abstract

pub_date

2015-03-15 00:00:00

pages

249-57

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(14)02413-9

journal_volume

183

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Is left ventricular diastolic function an independent marker of prognosis after acute myocardial infarction?

    abstract：BACKGROUND:In addition to clinical risk markers, indices of left ventricular (LV) systolic function are valuable prognostic markers after acute myocardial infarction (MI). Previous studies have also suggested that LV diastolic function may contribute with prognostic information. The present study assessed whether this ...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2004.05.006

    authors： Quintana M,Edner M,Kahan T,Hjemdahl P,Sollevi A,Rehnqvist N

    更新日期：2004-08-01 00:00:00

  • Left bundle branch block in dilated cardiomyopathy with intermediate left ventricular dysfunction: Clinical phenotyping and outcome correlates.

    abstract：BACKGROUND:Left bundle branch block (LBBB) negatively affects prognosis in heart failure patients with a reduced left ventricular ejection fraction (LVEF). Less is known about the prognostic role of LBBB in dilated cardiomyopathy (DCM) with intermediate LVEF (between 36% and 50%). We sought to assess the role of LBBB i...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.11.005

    authors： Gentile P,Paldino A,Cannatà A,Artico J,Barbati G,Ramani F,Fabris E,Aleksova A,Stolfo D,Zecchin M,Merlo M,Sinagra G

    更新日期：2019-03-01 00:00:00

  • Kidney function and the risk of heart failure in patients with new-onset atrial fibrillation.

    abstract：AIMS:Heart failure (HF) is the most common complication of patients with atrial fibrillation (AF), but possible risk factors or health consequences are not well described. Low kidney function is a risk factor for both AF and HF. We evaluated estimated glomerular filtration rate (eGFR) as a predictor of HF in patients w...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.08.003

    authors： Carrero JJ,Trevisan M,Evans M,Svennberg E,Szummer K

    更新日期：2020-12-01 00:00:00

  • Giant right atrial aneurysm: case report.

    abstract：:A 15-month-old boy with atrial fibrillation was found to have gross cardiomegaly on a chest radiography; further evaluation by echocardiography showed a giant right atrial aneurysm which is in the form of a cyst like lesion. The patient underwent successful surgical reduction of the right atrium converting his heart r...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2006.02.038

    authors： Imren Y,Halit V,Kula S,Olgunturk R

    更新日期：2006-10-10 00:00:00

  • Blood rheological properties are strongly related to the metabolic syndrome in middle-aged Chinese.

    abstract：:The current investigation sought to evaluate the relation between hemorheological properties and the metabolic syndrome. 1400 office workers aged 35 to 59 years were enrolled in this study. Waist circumference and blood pressure were determined. Plasma high-density lipoprotein (HDL cholesterol), triglyceride, fasting ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2005.11.104

    authors： Zhang L,Pu K,Zhang SY,Ren WQ

    更新日期：2006-09-20 00:00:00

  • Rupture of a pseudoaneurysm of a saphenous vein coronary arterial bypass graft presenting with superior caval venous obstruction.

    abstract：:We describe the first reported case of rupture of a pseudoaneurysm of a sapheneous vein coronary arterial bypass graft presenting with acute superior caval venous obstruction. The patient was successfully treated by urgent surgical excision of the graft. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(89)90171-x

    authors： Rosin MD,Ridley PD,Maxwell PH

    更新日期：1989-10-01 00:00:00

  • Remodeling in acute coronary syndromes: expectations and frustrations for risk assessment and therapy.

    abstract：:Matrix metalloproteinases are involved in the development of acute coronary syndromes, but they are not reliable clinical markers of the occurrence or the outcome of this syndrome. Many limitations in their assessment account for such failure. Functional genetic polymorphisms, as alternatives to plasma levels, might b...

    journal_title：International journal of cardiology

    pub_type： 评论,信件

    doi：10.1016/j.ijcard.2008.04.005

    authors： Fiotti N,Altamura N,Giansante C

    更新日期：2009-05-29 00:00:00

  • What is the association of lipid levels and incident stroke?

    abstract：BACKGROUND:The association between lipid levels and stroke rates is less than lipid levels and coronary heart disease (CHD). OBJECTIVE:To assess if there are geographic, racial, and ethnic differences in total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) a...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.06.091

    authors： Glasser SP,Mosher A,Howard G,Banach M

    更新日期：2016-10-01 00:00:00

  • Clinical significance of papillary muscle late enhancement detected via cardiac magnetic resonance imaging in patients with single old myocardial infarction.

    abstract：BACKGROUND:Contrast-enhanced cardiac magnetic resonance imaging (MRI) can depict papillary muscle (PM) necrosis or fibrosis by late enhancement (LE) of PM, but its clinical significance in old myocardial infarction (OMI) has been little understood. METHODS:Myocardial LE and PM-LE were detected with contrast imaging in...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2010.04.037

    authors： Okayama S,Uemura S,Soeda T,Onoue K,Somekawa S,Ishigami K,Watanabe M,Nakajima T,Fujimoto S,Saito Y

    更新日期：2011-01-07 00:00:00

  • Platelet reactivity in patients receiving a maintenance dose of P2Y12-ADP receptor antagonists undergoing elective percutaneous coronary intervention.

    abstract：BACKGROUND:P2Y12-ADP receptor blockade during percutaneous coronary intervention (PCI) is critical to prevent thrombotic events. In patients under chronic P2Y12 blockers, the use of additional loading dose (LD) before an elective PCI is debated. We aimed to investigate the rate of high on-treatment platelet reactivity ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.04.165

    authors： Bonello L,Laine M,Thuny F,Paganelli F,Lemesle G,Roch A,Kerbaul F,Dignat-George F,Berbis J,Frere C

    更新日期：2016-08-01 00:00:00

  • Non-vitamin K antagonist oral anticoagulants compared with warfarin at different levels of INR control in atrial fibrillation: A meta-analysis of randomized trials.

    abstract：BACKGROUND:The efficacy and safety of warfarin for stroke prevention in atrial fibrillation (AF) depend on the time in the therapeutic range (TTR) with an international normalised ratio (INR) of 2.0-3.0. This meta-analysis focused the relative efficacy and safety of non-VKA oral anticoagulants (NOAC) compared with warf...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijcard.2017.06.004

    authors： Carmo J,Ferreira J,Costa F,Carmo P,Cavaco D,Carvalho S,Morgado F,Adragão P,Mendes M

    更新日期：2017-10-01 00:00:00

  • Prevalence of significant QTc prolongation and long QT syndrome in adolescents with syncope.

    abstract：:A total of 664 high school students having >or=1 episode of syncope and 560 students without syncope (controls) underwent 12-lead ECG. A significant QT prolongation was defined as corrected QT (QTc)>470 ms in male and >480 ms in female. A diagnosis of LQTS was made by Schwartz's score. Most students had only 1 episode...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.07.102

    authors： Khositseth A,Wattanasirichaigoon D,Ruangkanchanasetr S

    更新日期：2009-01-24 00:00:00

  • Endocardial metastases as the only site of relapse in a patient with bladder carcinoma: a case report and review of the literature.

    abstract：:Tumors metastatic to the heart (cardiac metastases) are infrequent and few systematic studies on this topic have been published. Urothelial carcinomas are among the rarest associated with heart metastases and all cases reported to date concern autopsy examinations. We present the first report of urothelial carcinoma m...

    journal_title：International journal of cardiology

    pub_type： 信件,评审

    doi：10.1016/j.ijcard.2008.11.012

    authors： Mountzios G,Bamias A,Dalianis A,Danias P,Pantelidaki E,Nanas J,Dimopoulos MA

    更新日期：2010-04-01 00:00:00

  • Coronary risk factors and coronary atheroma burden at severely narrowing segments.

    abstract：BACKGROUND:While only few data exist correlating cardiovascular risk factors with volumetric measurements of coronary atheroma burden in patients with coronary artery disease, a recent report using intravascular ultrasound (IVUS) demonstrated independent predictors of atherosclerotic burden in a native coronary artery ...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2006.11.194

    authors： Kaneda H,Kataoka T,Ako J,Honda Y,Yock PG,Fitzgerald PJ

    更新日期：2008-02-20 00:00:00

  • Changes in renal function with percutaneous transluminal coronary angioplasty.

    abstract：:There is concern about adverse effects on renal function in patients with prolonged cardiac intervention procedures, when contrast media is used. To investigate this further we studied changes in renal function in 104 patients (79 male, 25 female; mean age 59.2, SD 9.8) undergoing routine elective percutaneous translu...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(99)00063-7

    authors： Lip GY,Rathore VS,Katira R,Singh SP,Watson RD

    更新日期：1999-07-31 00:00:00

  • Patients with higher body mass index treated with direct / novel oral anticoagulants (DOAC / NOAC) for atrial fibrillation experience worse clinical outcomes.

    abstract：INTRODUCTION:Due to fixed dosing of direct oral anticoagulants (DOACs), uncertainty exists about their efficacy in a population of obese/overweight patients. PATIENTS AND METHODS:We retrospectively investigated a real-life cohort of 325 DOAC anticoagulated patients with atrial fibrillation [179 receiving dabigatran (5...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.10.035

    authors： Lucijanic M,Jurin I,Jurin H,Lucijanic T,Starcevic B,Skelin M,Glasnovic A,Catic J,Jurisic A,Hadzibegovic I

    更新日期：2020-02-15 00:00:00

  • Changes in myocardial ischaemia during isosorbide dinitrate or indoramin therapy in patients with stable angina using relations between the ST segment and heart rate.

    abstract：:The effect of isosorbide dinitrate or indoramin on myocardial ischaemia was examined in patients with stable angina pectoris. In a prospective trial, randomization resulted in 8 and 9 patients, respectively, given isosorbide dinitrate in a dose of 30-90 mg daily, and indoramin in a dose of 75-225 mg daily; 2 of these ...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0167-5273(88)90239-2

    authors： Niveditha Y,Bishop N,Boyle RM,Stoker JB,Mary DA

    更新日期：1988-06-01 00:00:00

  • Serum levels of VEGF and basic FGF in the subacute phase of myocardial infarction.

    abstract：:We examined serial changes in serum levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) measured by ELISAs in 45 patients with acute myocardial infarction (AMI) who received heparin intravenously for 3 to 5 days after the onset and in 30 control subjects with an old myocardial...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(98)00251-4

    authors： Kawamoto A,Kawata H,Akai Y,Katsuyama Y,Takase E,Sasaki Y,Tsujimura S,Sakaguchi Y,Iwano M,Fujimoto S,Hashimoto T,Dohi K

    更新日期：1998-11-30 00:00:00

  • Direction, location, and size of shunt flow in congenital heart disease evaluated by ECG-gated multislice computed tomography.

    abstract：OBJECTIVE:To demonstrate the utility of multislice computed tomography (MSCT) in the evaluation of direction, location, and size of shunt flow in congenital heart disease. BACKGROUND:Transthoracic and transesophageal echocardiography, magnetic resonance imaging, and conventional angiography has been used to evaluate c...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2005.07.078

    authors： Funabashi N,Asano M,Sekine T,Nakayama T,Komuro I

    更新日期：2006-10-10 00:00:00

  • Value of analysis of the evolution of the pattern of the ST segment in exercise electrocardiograms.

    abstract：:We analysed retrospectively the exercise electrocardiogram records of all patients with positive exercise tests which, on subsequent coronary angiography, proved to be "false positives". The exercise records of 10 "false positive" patients were compared with the records of 10 patients with true positive tests in the s...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(90)90121-k

    authors： Bajaj R,Wasir HS

    更新日期：1990-12-01 00:00:00

  • Perioperative administration of enoximone and renal function after cardiac surgery: a propensity-matched analysis.

    abstract：BACKGROUND:Perioperative administration of enoximone has been shown to improve hemodynamics, organ function, and inflammatory response. Aim of the present study is to evaluate the impact of enoximone on postoperative renal function after on-pump cardiac surgery. METHODS:A total of 3727 patients undergoing cardiac surg...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.05.021

    authors： Angeloni E,Melina G,Roscitano A,Refice S,Capuano F,Comito C,Benedetto U,Sinatra R

    更新日期：2013-09-01 00:00:00

  • Right ventricular sugars and fats in chronic thromboembolic pulmonary hypertension.

    abstract：BACKGROUND/OBJECTIVES:Several studies have already shown the correlation between the right ventricle (RV) hemodynamic values and either glucose uptake or fatty acid uptake in the RV, respectively. However, there are few studies to compare the RV metabolic alteration before and after treatment for pulmonary hypertension...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.06.010

    authors： Sakao S,Daimon M,Voelkel NF,Miyauchi H,Jujo T,Sugiura T,Ishida K,Tanabe N,Kobayashi Y,Tatsumi K

    更新日期：2016-09-15 00:00:00

  • Prevention of ischaemia-induced coronary vascular dysfunction.

    abstract：:Myocardial ischaemia and reperfusion cause dysfunction of the coronary vasculature leading to a sustained reduction in coronary blood flow and an impairment of responses to both endothelium-dependent and endothelium-independent vasodilators. In contrast, when previously ischaemic arteries are removed from the myocardi...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(97)00246-5

    authors： Woodman OL,Hart JL,Sobey CG

    更新日期：1997-12-31 00:00:00

  • Glycative and oxidative stress are associated with altered thrombus composition in diabetic patients with ST-elevation myocardial infarction.

    abstract：BACKGROUND:The role of type 2 diabetes (T2DM) on composition of thrombus has not been fully characterized in patients with ST-elevation myocardial infarction (STEMI). AIMS:To elucidate the differences between diabetic and non-diabetic patients with STEMI in relation to the composition of coronary thrombus, and the pot...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.04.089

    authors： Sambola A,Ruiz-Meana M,Barba I,Del Blanco BG,Barrabés JA,Lip GY,Vilardosa Ú,Sansaloni S,Rello P,García-Dorado D

    更新日期：2017-09-15 00:00:00

  • Transradial access compared with femoral puncture closure devices in percutaneous coronary procedures.

    abstract：BACKGROUND:Transradial access (RA) is associated with less complications and is preferred by patients. Vascular closure devices (VCDs) may improve discomfort and may reduce complications associated with transfemoral access. Aim was to evaluate complications and discomfort associated with percutaneous coronary procedure...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2008.06.045

    authors： Sciahbasi A,Fischetti D,Picciolo A,Patrizi R,Sperduti I,Colonna G,Summaria F,Montinaro A,Lioy E

    更新日期：2009-11-12 00:00:00

  • Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats.

    abstract：:Although the state of hyperhomocysteinemia (HHcy) appears to be associated with higher risks of coronary, cerebral and peripheral vascular disease as well as with a number of other clinical conditions, the underlying molecular mechanisms are not fully elucidated. There is strong evidence, however, that HHcy could indu...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(03)00108-6

    authors： El-Saleh SC,Al-Sagair OA,Al-Khalaf MI

    更新日期：2004-01-01 00:00:00

  • Influence of circumferential pulmonary vein isolation for atrial fibrillation on ST elevation in patient with Brugada syndrome.

    abstract：:We present a patient with Brugada syndrome and paroxysmal atrial fibrillation who underwent circumferential pulmonary vein isolation. His electrocardiogram showed normal sinus rhythm and first-degree AV block (P-R 280 ms) with coved-type ST elevation in V1-2 (+2.0 mm) before ablation. During ablation around the left p...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2009.04.010

    authors： Tomita T,Aizawa K,Shimada K,Motoki H,Otagiri K,Koshikawa M,Kasai H,Izawa A,Kumazaki S,Tsutsui H,Koyama J,Ikeda U

    更新日期：2011-06-02 00:00:00

  • Effect of aging on left ventricular filling in untreated hypertensive patients.

    abstract：:The aim of this study was to evaluate the influence of age and other clinical and echocardiographic parameters on left ventricular filling in a group of 174 untreated patients with mild to moderate hypertension (aged 20-82 years; mean 51.2 years) and in 189 age-matched normotensive subjects. All subjects underwent an ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(94)02225-8

    authors： Manca C,Aschieri D,Piazza A,Conti M,Barilli AL,Tiberti G,Bolognesi R,Cavatorta A,Borghetti A

    更新日期：1995-02-01 00:00:00

  • Congestive heart failure in thyrotoxicosis.

    abstract：:Congestive heart failure due to thyrotoxicosis without preexisting heart disease is rare. Indeed, the very existence of a thyrotoxic heart disease has been much discussed. We describe a 44-year-old woman in whom thyrotoxicosis was found to be the sole cause of congestive heart failure. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(88)90065-4

    authors： Toft P,Bøtker HE

    更新日期：1988-03-01 00:00:00

  • Clinical predictors of cardiac events in patients with isolated syncope and negative electrophysiologic study.

    abstract：BACKGROUND:Patients with syncope or near syncope of unknown etiology represent a great challenge to cardiologists. An initial symptomatic episode triggers a series of diagnostic analysis which remain unsatisfactory when negative. More invasive tools such as electrophysiologic testing yield only partial answers to risk ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2005.05.025

    authors： Da Costa A,Gulian JL,Romeyer-Bouchard C,Messier M,Zarqane N,Samuel B,Khiel A,Isaaz K

    更新日期：2006-04-28 00:00:00