Abstract：
BACKGROUND:The association between lipid levels and stroke rates is less than lipid levels and coronary heart disease (CHD). OBJECTIVE:To assess if there are geographic, racial, and ethnic differences in total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride levels with incident stroke. METHODS:From the REasons for Geographic And Racial Differences in Stroke (REGARDS) study we evaluated baseline levels of LDL-C, HCL-C, TC, Non-HDL-C (Total-HDL-C) and triglycerides in participants free of prevalent stroke at baseline. Cox Proportional-Hazard models were the main analytical tool used to examine the association between incident stroke and lipids. For each adjusted lipid measure (LDL-C, HDL-C, triglycerides, TC, and non-HDL-C) we calculated a series of incremental models. RESULTS:The analysis cohort was 23,867 participants with a mean follow-up time of 7.5±2.9years, and 1031 centrally adjudicated strokes (874 ischemic and 77 hemorrhagic strokes). HDL-C baseline level was associated with an overall unadjusted 13% risk reduction (HR 0.87, 95% confidence interval [CI]: 0.81-0.93; p<0.05; 14% for ischemic and 16% for hemorrhagic strokes), and TC with an 8% (HR 0.92, 95%CI: 0.87-0.99; p<0.05) risk reduction of all strokes. When the results were fully adjusted a significant association was observed only for LDL-C and non-HDL-C and ischemic stroke. There were no significant differences in these associations when adjusted for age, race, age∗race, gender, education, region, or income. CONCLUSION:In a disease free population, LDL-C and non-HDL-C baseline levels are significantly associated with the risk of ischemic stroke.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Glasser SP,Mosher A,Howard G,Banach Mdoi
10.1016/j.ijcard.2016.06.091subject
Has Abstractpub_date
2016-10-01 00:00:00pages
890-4eissn
0167-5273issn
1874-1754pii
S0167-5273(16)31102-0journal_volume
220pub_type
杂志文章abstract：BACKGROUND:There are no studies on the long term clinical outcomes and complications in the adult patient with pulmonary atresia with intact ventricular septum (PA/IVS). This study reviews our experience with a limited group of adult survivors of PA/IVS seen in our adult congenital clinics. METHODS:Twenty adult patien...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2011.04.026
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Many patients fail to receive β-blockers before cardiac resynchronization therapy defibrillator (CRT-D) implantation, or receive them at a suboptimal dose, and require optimization after implantation. We assessed the effectiveness of a structured program for β-blocker titration in CRT-D patients followed up ...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2017.02.015
更新日期：2017-06-01 00:00:00
abstract：:A growing pool of evidence has shown that enhanced external counterpulsation (EECP) is a non-invasive, safe, low-cost, and highly beneficial therapy for patients with coronary artery disease. However, the exact mechanisms of benefit exerted by EECP therapy remain only partially understood. The favorable hemodynamic ef...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2012.04.003
更新日期：2013-06-05 00:00:00
abstract：BACKGROUND:Recent clinical trials have evaluated the cardiovascular outcomes of dipeptidyl peptidase-4 (DPP-4) inhibitors in patients with type 2 diabetes mellitus (T2DM), but those with end-stage renal disease (ESRD) were ineligible for participation in these trials. We aimed to characterize the impact of DPP-4 inhibi...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.05.062
更新日期：2016-09-01 00:00:00
abstract：:Tumors metastatic to the heart (cardiac metastases) are infrequent and few systematic studies on this topic have been published. Urothelial carcinomas are among the rarest associated with heart metastases and all cases reported to date concern autopsy examinations. We present the first report of urothelial carcinoma m...
journal_title：International journal of cardiology
pub_type： 信件,评审
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abstract：BACKGROUND:Early angiotensin-converting enzyme (ACE) inhibition is able to re-program spontaneously hypertensive rats (SHR) to express an attenuated form of disease in adulthood. METHODS:Three groups of animals (n=5 each) were studied: Wistar male rats, SHR males, and SHR males obtained from dams treated with enalapri...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2004.03.029
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journal_title：International journal of cardiology
pub_type： 杂志文章
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abstract：BACKGROUND:Recent population-based estimates for long-term cardiovascular disease (CVD) mortality after hospitalization for a first acute myocardial infarction (AMI) are not well established. METHODS:Data from the Swedish hospital discharge and death registries were used to record all first-ever hospital admissions in...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2010.10.047
更新日期：2012-03-22 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章
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更新日期：2015-01-20 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.04.010
更新日期：2016-07-01 00:00:00
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journal_title：International journal of cardiology
pub_type： 信件
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journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析,评审
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更新日期：2018-06-15 00:00:00
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journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2009.04.018
更新日期：2010-11-05 00:00:00
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journal_title：International journal of cardiology
pub_type： 传,历史文章
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更新日期：2015-03-01 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章
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更新日期：1997-08-29 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(92)90133-n
更新日期：1992-10-01 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章
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更新日期：2016-10-15 00:00:00
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journal_title：International journal of cardiology
pub_type： 信件
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更新日期：2007-09-03 00:00:00
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journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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journal_title：International journal of cardiology
pub_type： 杂志文章,随机对照试验
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更新日期：2007-08-09 00:00:00
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journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2008.12.039
更新日期：2010-08-20 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(86)90168-3
更新日期：1986-01-01 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
abstract：AIM:To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes. METHODS:We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, m...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2004.12.051
更新日期：2006-01-04 00:00:00
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journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章
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更新日期：1992-01-01 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章
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更新日期：2016-10-15 00:00:00
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journal_title：International journal of cardiology
pub_type： 信件
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更新日期：2004-03-01 00:00:00
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journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析
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更新日期：2018-08-15 00:00:00
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journal_title：International journal of cardiology
pub_type： 信件
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更新日期：2007-01-31 00:00:00
