Abstract:
OBJECTIVE:To identify factors associated with troponin elevation and to measure the effect of elevated troponin on survival in cancer patients participating in phase I trials. METHODS:Clinical characteristics, cardiovascular risk factors, and biological data from consecutive patients treated in phase I trials (January 2010-November 2012) were reviewed. Troponin value was measured for each patient before study-drug administration and then weekly. Cardiac troponin I was considered elevated if >0.06ng/mL. Incidence and relative risk of elevated troponin adjusted for potential confounding factors were estimated using multivariable Poisson regression models. A conditional Cox proportional hazards model was used to compare overall survival in patients with elevated troponin matched to patients without troponin elevation recruited in the same trial. RESULTS:Of 463 patients, 42 (9%) experienced ≥1 episode of troponin I elevation after a median of 5weeks (interquartile range: 3-13) from drug initiation. Crude incidence of troponin elevation was 36/1000 person-months (95% confidence interval [CI]: 25-47). Troponin elevation was more frequent in patients exposed to antiangiogenic compounds versus other treatments (relative risk: 1.9, 95% CI: 1.1-3.3). Median overall survival from drug initiation was 9months (95% CI: 8-10), and 8months (95% CI: 2-13) in patients with troponin elevation. In the case-control analysis, risk of death was higher in patients with troponin elevation (hazard ratio: 2.9, 95% CI: 1.2-6.8). CONCLUSION:Patients exposed to antiangiogenic compounds had a higher risk of troponin elevation, which was associated with a higher risk of death.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Hollebecque A,Lanoy E,Troallen F,Soulat-Dufour L,Massard C,Bahleda R,Varga A,Gazzah A,Postel-Vinay S,Ribrag V,Deutsch E,Angevin E,Boccara F,Cohen A,Soria JC,Ederhy Sdoi
10.1016/j.ijcard.2016.04.010subject
Has Abstractpub_date
2016-07-01 00:00:00pages
364-9eissn
0167-5273issn
1874-1754pii
S0167-5273(16)30685-4journal_volume
214pub_type
杂志文章abstract:BACKGROUND/OBJECTIVES:Familial hypercholesterolemia (FH) is a genetic disorder that leads to premature heart disease or stroke if untreated. Statins are effective for individuals with FH but less than 20% of actual cases are diagnosed in the US and many people are not adherent to treatment. Using new knowledge regardin...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.12.070
更新日期:2015-02-15 00:00:00
abstract:BACKGROUND:In this prospective study we evaluated the relationship between thromboxane B2 (TXB2), prostacyclin (PGI2) and lactate concentrations, and the improvement of walking abilities and endothelial function in patients with peripheral artery disease (PAD) undergoing a supervised treadmill training program (STTP). ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.07.274
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Safe administration of warfarin presents challenges due to a narrow therapeutic INR range and significant variability in inter-individual dose response. Bleeding secondary to warfarin use is a leading cause of hospitalization. METHODS:Five warfarin dosing algorithms were assessed for accuracy of predicted c...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.03.055
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:Studies comparing the drug-eluting balloon (DEB) with contemporary drug-eluting stent (DES) in the treatment of in-stent restenosis (ISR) have been scarce. We compared that the efficacy and safety of contemporary DES versus DEB in unselected, real world patients of ISR occurred in bare-metal stent or DES. M...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2016.12.176
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Sixty-four-slice multidetector spiral computed tomography (CT) has improved temporal resolution and reduced acquisition time. We aimed to evaluate the functional analysis using 64-slice CT comparing with echocardiography, electrocardiographically gated single-photon emission tomography (SPECT) and cardiovasc...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.06.017
更新日期:2008-08-01 00:00:00
abstract::Current studies evaluating the effect of serum potassium levels on mortality in patients with ST elevation myocardial infarction (STEMI) are lacking. We analyzed retrospectively 3760 patients diagnosed with STEMI. Mean serum potassium levels were categorized accordingly: <3.0, 3.0 to <3.5, 3.5 to <4.0, 4.0 to <4.5, 4....
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.07.024
更新日期:2016-10-15 00:00:00
abstract::Cheyne-Stokes respiration (CSR) is indicative of adverse outcome in patients with chronic heart failure (CHF). We evaluated the use of brain natriuretic peptide (BNP) plasma levels to predict CSR in CHF patients. In this cross-sectional study, overnight polygraphy and cardiac work-up were performed and neurohumoral ac...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.03.031
更新日期:2007-03-02 00:00:00
abstract::Anti-cardiac receptor autoantibodies have been studied intensively last 10 years. A growing evidence, both in vitro and in vivo and both clinical and experimental studies, have supported that these anti-cardiac receptor autoantibodies, mainly anti-beta1 adrenoceptor autoantibodies, play a very important pathophysiolog...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2006.05.013
更新日期:2006-09-10 00:00:00
abstract:PURPOSE:The prospective EUROVISION Registry was designed to capture patterns of use and short term outcomes in consecutive patients undergoing PCI with bivalirudin (BIV) in European centres. METHODS:A total of 2018 consecutive BIV-treated patients were included from 58 sites in 5 countries (Germany, Italy, France, Aus...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.03.003
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Dyspnea on exertion is common to both heart failure (HF) and chronic obstructive pulmonary disease (COPD), and it is important to discriminate whether symptoms are caused by HF or COPD in clinical practice. The ventilatory equivalent for carbon dioxide (V̇E/V̇CO2) slope and V̇E intercept (a reflection of pul...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.09.007
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Oestrogen alters megakaryocyte number in humans and mice. In mice, high-dose oestrogen stimulates an initial increase in megakaryocyte number followed by a decrease. However, the cellular action, effect of physiologically circulating and smaller supra-physiological oestrogen doses and whether changes in mega...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.06.037
更新日期:2006-05-24 00:00:00
abstract:BACKGROUND:Epidemiologic data regarding the role of inflammation in atherosclerosis have been based mainly on Caucasian populations. Thus, we analyzed the cross-sectional relationships of inflammatory biomarkers to cardiovascular risk factors (CVRF) and related variables in a large group of healthy Chinese men, a popul...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.07.034
更新日期:2006-06-16 00:00:00
abstract::The dihydropyridine calcium channel blocking agent amlodipine is an effective anti-hypertensive agent and its use (in doses of 5 or 10 mg/day/kg body weight) was investigated in male Wistar rats with hypertension induced by aortic constriction. Controls were sham-operated and pair-fed. At the end of the study, rates o...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(96)02872-0
更新日期:1997-02-01 00:00:00
abstract:INTRODUCTION:The progression of aortic stenosis (AS) has been shown to be faster in patients with the metabolic syndrome. We sought to determine the relationships between blood pressure, inflammation, oxidative stress and valvular inflammation in a population of normotensive and prehypertensive patients with AS. METHO...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.05.054
更新日期:2010-12-03 00:00:00
abstract:BACKGROUND:Multislice computed tomography (MSCT) is a non-invasive, less expensive, low-radiation alternative to coronary angiography (CAG) prior to valvular heart surgery. MSCT has a high negative predictive value for coronary artery disease (CAD) but previous studies of patients with valvular disease have shown that ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.11.078
更新日期:2017-01-15 00:00:00
abstract:BACKGROUND:The study sought to determine the impact of high residual platelet reactivity (HRPR) on long-term cardiac mortality in diabetic patients treated with PCI for CTO. No data exist about the impact of HRPR after 600 mg clopidogrel loading on long-term clinical outcome in patients with diabetes mellitus and treat...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.04.052
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:Normal standards for peak oxygen consumption (VO2peak) are controversial because they tend to be population and protocol specific. This study was undertaken to examine the association between percentage of age-predicted VO2peak and all-cause hospital readmission in cardiac outpatients who were referred to an...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.02.057
更新日期:2020-07-01 00:00:00
abstract::Cardiac involvement in echinococcosis remains a singular finding, possibly associated with confusing symptomatology. We report the original case of a 17 year-old young woman, referred to our cardiology department for repeated exertion syncopes, and ultimately, proven through echocardiography, serologies and magnetic r...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.04.077
更新日期:2009-07-24 00:00:00
abstract:BACKGROUND:Several intervention studies have investigated the relation between potassium intake and blood-pressure, particularly in hypertensive subjects. However, uncertainties still exist about the existence and the amount of such an effect, and about the role of some potential effect-modifiers, including the baselin...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2016.12.048
更新日期:2017-03-01 00:00:00
abstract::In this article the authors deal with the intricate relationship between acute brain injuries and stress cardiomyopathies. The complexity of heart–brain relationship raises some questions about the occurrence of Takotsubo cardiomyopathy in young patients with acute brain ischemia and vice versa. ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.05.003
更新日期:2010-11-19 00:00:00
abstract::There is concern about adverse effects on renal function in patients with prolonged cardiac intervention procedures, when contrast media is used. To investigate this further we studied changes in renal function in 104 patients (79 male, 25 female; mean age 59.2, SD 9.8) undergoing routine elective percutaneous translu...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(99)00063-7
更新日期:1999-07-31 00:00:00
abstract:BACKGROUND:The role of right atrial (RA) dysfunction in patients with pulmonary hypertension (PH), as evaluated by two-dimensional speckle-tracking echocardiography (2D-STE) remains to be determined. METHODS:Sixty consecutive PH patients and 30 healthy volunteers were included. RA function was evaluated by 2D-STE, and...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.11.093
更新日期:2018-03-15 00:00:00
abstract:UNLABELLED:The study aimed at checking effects exerted by captopril (C) on human myocardial ACE system as well as the role played by tissue ACE inhibition in reducing reperfusion damage. A human experimental model was used during cardioplegia due to aorto-coronary-by-pass (CABG). Fifty-four patients with coronary arter...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(93)90052-i
更新日期:1993-12-31 00:00:00
abstract::The mortality and morbidity were assessed during a 2-year follow-up in an acute intervention trial in suspected acute myocardial infarction with metoprolol (a selective beta 1-blocker). On admission to the trial, the 1395 participating patients were randomly allocated to metoprolol or placebo for 3 months. Thereafter,...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(86)90010-0
更新日期:1986-03-01 00:00:00
abstract::We report the case of a 64 year old man with two vessel coronary artery disease and a left main coronary artery to pulmonary artery fistula. He underwent coronary artery bypass grafting, but the coronary artery fistula was not closed. He developed recurrent angina due to coronary steal from the distal left anterior de...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.04.003
更新日期:2009-11-12 00:00:00
abstract::To test the hypothesis that neurotrophins might undergo significant changes in acute coronary syndrome (ACS), NGF and BDNF levels in sera of patients suffering of ACS and in control subjects were measured by enzyme-linked immunosorbent assay (ELISA). Plasma concentrations of glucose, total cholesterol, triglycerides, ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2004.10.041
更新日期:2005-06-22 00:00:00
abstract:CONTEXT:Transcatheter ablation of atrial fibrillation (AF) has undergone important development, with acceptable midterm results in terms of the safety and recurrence. A meta-analysis was performed to identify the periprocedural complications, midterm success rates and predictors of recurrence after AF ablation. METHOD...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijcard.2012.05.008
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Individuals with hypertension and hyperuricemia have an increased risk of coronary artery disease and cerebral vascular disease as compared to patients with normal uric acid levels. Our aim is to determine the prevalence of hyperuricemia in hypertensive patients in Taiwan, and whether serum uric acid (SUA) i...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2009.11.024
更新日期:2011-05-05 00:00:00
abstract:BACKGROUND:In addition to clinical risk markers, indices of left ventricular (LV) systolic function are valuable prognostic markers after acute myocardial infarction (MI). Previous studies have also suggested that LV diastolic function may contribute with prognostic information. The present study assessed whether this ...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ijcard.2004.05.006
更新日期:2004-08-01 00:00:00
abstract::A newborn with preductal coarctation and ventricular septal defect had a subaortic aneurysm which protruded into the left atrium causing intractable pulmonary oedema. The subaortic aneurysm was congenital. It was clearly identified by cross-sectional echocardiography which, in serial studies, showed it to be increasin...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(87)90183-5
更新日期:1987-01-01 00:00:00