Abstract:
BACKGROUND:Several studies have reported that hepatitis B virus (HBV) infection affects the risk of coronary heart disease. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to better understand it. METHODS:Relevant studies published before October 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. The relationships between HBV and the risk of coronary heart disease were assessed using Relative risk (RR) values and the corresponding 95% confidence intervals (CIs). We used the random effects model proposed by DerSimonian and Laird to quantify the relationship. RESULTS:Nine articles, including 65,058 HBV-infected patients and 534,998 uninfected controls, were included in the meta-analysis. The present study does not support that HBV infection is associated with the risk of coronary heart disease (RR = 0.99, CI = 0.76-1.22; I2 = 68.9%). Sensitivity analysis and 'trim and fill' method yielded similar results. No evidence of publication bias was observed. CONCLUSIONS:HBV infection does not increase the risk of coronary heart disease. The associations were not significant both in cohort studies and in case-control studies.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Wang Y,Xiong J,Niu M,Xu W,Xu K,Zhong Hdoi
10.1016/j.ijcard.2018.04.059subject
Has Abstractpub_date
2018-08-15 00:00:00pages
204-209eissn
0167-5273issn
1874-1754pii
S0167-5273(18)30178-5journal_volume
265pub_type
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2019-02-15 00:00:00
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pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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