Abstract:
OBJECTIVE:Free fatty acid inhibition with trimetazidine (TMZ) improves myocardial metabolism and myocardial ischemia in patients with coronary artery disease (CAD). Because of its effect on myocardial glucose utilization TMZ may represent a therapeutic option in diabetic patients with CAD. Aim of the present study was to evaluate whether the metabolic effect of TMZ may improve episodes of myocardial ischemia in diabetic patients with CAD. RESEARCH DESIGN AND METHODS:We assessed the effect of TMZ on 24 h ambulatory ECG monitoring (AEM) in 30 patients (22 males and 8 females, mean (SE) age 67+/-6.5 years) with NIDDM and ischemic cardiomyopathy. Patients were randomized to receive on top of standard therapy either TMZ (20 mg, tds) or placebo (tds) and were evaluated at baseline and after 6 months. RESULTS:Patients randomized to TMZ or placebo were comparable regarding demographic data, distribution of CAD, and glicated haemoglobin levels. TMZ significantly reduced the number of episodes of transient myocardial ischemia (-24% compared to baseline, p<0.01; -27% compared to placebo, p<0.01), and Total Ischemic Burden (-28% compared to baseline, p<0.01; -29% compared to placebo, p<0.01). TMZ also significantly reduced the number of silent episodes of myocardial ischemia (-42% compared to baseline and -39% compared to placebo, p<0.01) and the time of silent myocardial ischemia/24 h (-37% compared to baseline and -35% compared to placebo, p<0.01). No significant changes in heart rate were detected between baseline, placebo and TMZ evaluations. CONCLUSIONS:TMZ is effective in reducing silent and symptomatic episodes of transient myocardial ischemia in diabetic patients with CAD on standard anti-anginal therapy.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Marazzi G,Wajngarten M,Vitale C,Patrizi R,Pelliccia F,Gebara O,Pierri H,Ramires JA,Volterrani M,Fini M,Rosano GMdoi
10.1016/j.ijcard.2006.08.082subject
Has Abstractpub_date
2007-08-09 00:00:00pages
79-84issue
1eissn
0167-5273issn
1874-1754pii
S0167-5273(06)01204-6journal_volume
120pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Safe administration of warfarin presents challenges due to a narrow therapeutic INR range and significant variability in inter-individual dose response. Bleeding secondary to warfarin use is a leading cause of hospitalization. METHODS:Five warfarin dosing algorithms were assessed for accuracy of predicted c...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.03.055
更新日期:2020-10-15 00:00:00
abstract:OBJECTIVE:In this paper we present an attempt at noninvasive imaging of distributed myocardial electrical activity in patients suffering from myocardial infarction and in healthy subjects. Although advances have been made, noninvasive three-dimensional imaging of cardiac electrophysiological activity is still in its in...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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更新日期:1998-03-13 00:00:00
abstract::Coronary artery diseases and particularly acute myocardial infarction are the leading causes of mortality and morbidity in western countries. Despite the achievements of the last decades with the advent of double antiplatelet therapy, new antithrombotics and reperfusion strategies (either pharmacological or mechanical...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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abstract::Tissue valve dystrophic calcification, resulting in hemodynamic regurgitation and/or stenosis, is the most serious complication when bioprosthetic heart valves are concerned. The objective of this investigation was to define morphologically the sequential development of calcific deposits in pericardial tissue cusps of...
journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:To investigate the impact of concomitant asymptomatic peripheral artery disease (PAD) and pre-existing coronary artery disease (CAD) on cardiovascular events (CVEs) in atrial fibrillation (AF) patients. METHODS:Prospective multicenter study including 1138 anticoagulated AF patients. PAD was diagnosed by can...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2018-03-15 00:00:00
abstract:BACKGROUND:Excessive atrial ectopic activity (EAEA) has been related with an increased risk of atrial fibrillation (AF) and stroke but different cutoff values have been used. We aimed to determine the association between EAEA and stroke, AF and overall death. METHODS:Consecutive 24-hour Holter monitoring performed bet...
journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2017-12-15 00:00:00
abstract:OBJECTIVE:To analyze whether left ventricular dyssynchrony (LVD) at baseline is predictive for long-term outcome in heart failure (CHF) patients with left ventricular (LV) dysfunction and conduction disturbances treated with cardiac resynchronization therapy (CRT). METHODS:In 535 consecutive individuals with CHF sched...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.06.060
更新日期:2013-10-09 00:00:00
abstract:BACKGROUND:Stents are now widely used in Hong Kong and China and there is a clinical impression that restenosis is less common because of the lower prevalence of coronary artery disease and associated risk factors in the Chinese. However, there are no published data on angiographic stent restenosis rates in Chinese pat...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.06.001
更新日期:2005-06-22 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.03.095
更新日期:2013-10-03 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1990-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2014-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.09.009
更新日期:2014-11-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.11.145
更新日期:2010-05-28 00:00:00
abstract:OBJECTIVES:To study coronary heart disease (CHD) incidence versus other cause of death using the cumulative incidence function and the competing risks procedures to disentangle the differential role of risk factors for different end-points. MATERIAL AND METHODS:We compared standard Cox and Fine-Gray models among 1677 ...
journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2016-09-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.03.092
更新日期:2007-08-09 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(02)00588-0
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:This study examined the accuracy of cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometry (RE) in the predicting coronary artery disease (CAD) severity and prognosis. METHODS:Forty Caucasian subjects, mean age 63.5 ± 7.6, with significant coronary artery lesions (≥50%) were inc...
journal_title:International journal of cardiology
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更新日期:2019-06-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2007-10-01 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-09-15 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-08-01 00:00:00
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journal_title:International journal of cardiology
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更新日期:2017-09-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
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