Abstract:
BACKGROUND:Peripheral blood-based gene expression patterns have been investigated as biomarkers to monitor the immune system and rule out rejection after heart transplantation. Recent advances in the high-throughput deep sequencing (HTS) technologies provide new leads in transcriptome analysis. METHODS:By performing Solexa/Illumina's digital gene expression (DGE) profiling, we analyzed gene expression profiles of PBMCs from 6 quiescent (grade 0) and 6 rejection (grade 2R&3R) heart transplant recipients at more than 6 months after transplantation. Subsequently, quantitative real-time polymerase chain reaction (qRT-PCR) was carried out in an independent validation cohort of 47 individuals from three rejection groups (ISHLT, grade 0,1R, 2R&3R). RESULTS:Through DGE sequencing and qPCR validation, 10 genes were identified as informative genes for detection of cardiac transplant rejection. A further clustering analysis showed that the 10 genes were not only effective for distinguishing patients with acute cardiac allograft rejection, but also informative for discriminating patients with renal allograft rejection based on both blood and biopsy samples. Moreover, PPI network analysis revealed that the 10 genes were connected to each other within a short interaction distance. CONCLUSIONS:We proposed a 10-gene signature for heart transplant patients at high-risk of developing severe rejection, which was found to be effective as well in other organ transplant. Moreover, we supposed that these genes function systematically as biomarkers in long-time allograft rejection. Further validation in broad transplant population would be required before the non-invasive biomarkers can be generally utilized to predict the risk of transplant rejection.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Chen Y,Zhang H,Xiao X,Jia Y,Wu W,Liu L,Jiang J,Zhu B,Meng X,Chen Wdoi
10.1016/j.ijcard.2013.03.095subject
Has Abstractpub_date
2013-10-03 00:00:00pages
2726-33issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(13)00526-3journal_volume
168pub_type
杂志文章abstract::Fifty three of the 5778 patients included in the MIAMI (Metoprolol in Acute Myocardial Infarction) trial were investigated with long-term ECG recordings in order to evaluate the effect of acute beta-blockade on premature ventricular complexes in and after acute myocardial infarction. Twenty five patients were given pl...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::Pulsus paradoxus or the paradoxical pulse is an exaggeration of the normal inspiratory decrease in systolic blood pressure. The current definition of pulsus paradoxus is an inspiratory drop in systolic blood pressure>10 mm Hg. This physical sign can occur in conditions like cardiac tamponade, constrictive pericarditis...
journal_title:International journal of cardiology
pub_type: 历史文章,杂志文章,收录出版
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abstract::ACEI and AT1 receptor antagonists are the drugs most consistently shown to reduce ADMA level in humans. Unfortunately, most of the human studies addressing the effect of pharmacotherapy on ADMA metabolism were accomplished on small patient subgroups and were relatively shortlasting. Besides, L-arginine was rarely meas...
journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
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abstract:BACKGROUND:Atrial fibrillation (AF) is the most common sustained cardiac tachyarrhythmia and is often an occasional diagnosis in the absence of known cardiac disease. The aim of this study is to describe an Italian patient population with AF followed by their General Practitioners (GPs) using a telecardiology service. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2003.12.005
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2012-06-28 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 信件
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pub_type: 杂志文章,评审
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更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0167-5273(90)90121-k
更新日期:1990-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
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更新日期:2013-09-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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更新日期:2019-07-01 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2008-04-10 00:00:00
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更新日期:2020-02-15 00:00:00