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The importance of right ventricular evaluation in risk assessment and therapeutic strategies: Raising the bar in pulmonary arterial hypertension.

Abstract：

:Pulmonary arterial hypertension is an obstructive pulmonary vasculopathy that leads to increased pulmonary vascular resistance, right ventricular overload and failure, and death. Patients' clinical status and prognosis depend mostly on the capability of the right ventricle to adapt to the increased afterload, maintain function, and preserve cardiac output. As a result, reducing the hemodynamic burden of the right ventricle should be a key target of current treatments, along with improvement in WHO functional class, 6-minute walk distance, and rates of hospitalization. However, physicians still find it challenging to integrate the evaluation of right ventricular function into widely accepted clinical parameters in order to stratify patients more accurately. This limitation is very relevant, since higher-risk patients are more likely to benefit from a more aggressive therapeutic approach. We analyzed the hemodynamic burden in pulmonary arterial hypertension, the importance of echocardiographic evaluation of the right ventricle, the impact of current treatments on hemodynamic parameters, and the identification of patients who are more likely to benefit from a more aggressive therapeutic approach.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Badagliacca R,Papa S,Matsubara H,Lang IM,Poscia R,Manzi G,Vizza CD

doi

10.1016/j.ijcard.2019.10.043

subject

Has Abstract

pub_date

2020-02-15 00:00:00

pages

183-189

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(19)34332-3

journal_volume

301

pub_type

杂志文章,评审

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