QTc interval prolongation during infusion with dipyridamole or adenosine.


:The aim of our study was to discover whether there was a relationship between the QTc interval prolongation on the standard 12-lead electrocardiogram (ECG) and provoked myocardial ischemia. Since the increase of adenosine plasma levels, obtained either with adenosine or dipyridamole (an adenosine reuptake inhibitor) infusion, has been used to test the coronary artery reserve in patients affected by coronary artery disease, the QTc interval modifications during dipyridamole or adenosine echocardiographic stress test were evaluated. Twenty-five patients admitted to our Institute for evaluation of chest pain of suspected myocardial origin underwent an echocardiographic dipyridamole stress test (0.84 mg/kg over 10 min) after discontinuation of antianginal treatment. Of these patients, 10 underwent an echocardiographic adenosine stress test (scalar doses of 50, 75, 100, 140 micrograms/kg/min) after 48-72 h. The Bazett formula was used to evaluate the QTc interval. After dipyridamole and adenosine administration, a significant prolongation of the QTc interval was observed only in those patients who had positive test results. Our data suggested that QTc interval prolongation during pharmacological stress tests might be considered a marker of myocardial ischemia.


Int J Cardiol


Guideri F,Ferber D,Galgano G,Isidori S,Blardi P,Pasini FL,Di Perri T




Has Abstract


1995-01-27 00:00:00














  • Thrombolytic and antithrombotic treatment in myocardial infarction: main achievements and future perspectives.

    abstract::Several trials enrolling thousands of patients have demonstrated the beneficial effect of thrombolytic therapy on survival in patients with acute myocardial infarction. Three large trials have compared the effect of different thrombolytic agents on mortality from myocardial infarction: GISSI-2/International trial, ISI...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Agnelli G

    更新日期:1995-08-01 00:00:00

  • Predictors and clinical implications of stent thrombosis in patients with ST-segment elevation myocardial infarction: Insights from the EXAMINATION trial.

    abstract:BACKGROUND:Few data are available about safety of second generation drug eluting stents in an all-comer ST elevation myocardial infarction (STEMI) population. We sought to investigate the predictors and clinical implications of 1-year stent thrombosis (ST) in patients with STEMI, included in the EXAMINATION trial. MET...

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    pub_type: 杂志文章,随机对照试验


    authors: Brugaletta S,Sabate M,Martin-Yuste V,Masotti M,Shiratori Y,Alvarez-Contreras L,Cequier A,Iñiguez A,Serra A,Hernandez-Antolin R,Mainar V,Valgimigli M,Tespili M,den Heijer P,Bethencourt A,Vazquez N,Gomez-Lara J,Backx B,

    更新日期:2013-10-03 00:00:00

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    abstract:BACKGROUND:Obesity and metabolic syndrome are important risk factors for atrial fibrillation. High plasma concentrations of monounsaturated fatty acids, including oleic acid (OLA), are frequently noted in obese individuals and patients with metabolic syndrome. However, it is not clear whether monounsaturated fatty acid...

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    authors: Lin YK,Chen YC,Kao YH,Tsai CF,Yeh YH,Huang JL,Cheng CC,Chen SA,Chen YJ

    更新日期:2014-09-01 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Zeller M,Labalette-Bart M,Juliard JM,Potier L,Feldman LJ,Steg PG,Cottin Y,Roussel R

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    abstract::A 57-year-old woman with acute left leg ischemia due to popliteal artery occlusion and deep T-wave inversion at ECG revealed she had suffered, the day before, from typical chest pain after a confrontational argument; yet, she had not sought medical assistance. Echocardiography showed left ventricular wall motion abnor...

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    authors: Andò G,Saporito F,Trio O,Cerrito M,Oreto G,Arrigo F

    更新日期:2009-05-01 00:00:00

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    abstract:BACKGROUND:High-density lipoprotein cholesterol (HDL-C) is a strong inverse predictor of cardiovascular events. The aim of the current study was to evaluate the correlation between changes in HDL-C and subsequent cardiovascular events. METHODS:Study population comprised 13,037 subjects free of cardiovascular disease w...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Milwidsky A,Kivity S,Kopel E,Klempfner R,Berkovitch A,Segev S,Sidi Y,Goldenberg I,Maor E

    更新日期:2014-05-01 00:00:00

  • Negative pressure pulmonary edema complicating an electrophysiological study.

    abstract::We report on a case of acute non-cardiogenic negative-pressure pulmonary edema developed during an ablation procedure of an accessory pathway in a patient with no structural heart disease. That potentially serious complication has not been previously reported during an interventional cardiology procedure. ...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Pachón M,Arias MA,Castellanos E,Puchol A,Rodríguez-Padial L

    更新日期:2009-11-12 00:00:00

  • Long-term prognostic significance of urinary sodium concentration in patients with acute heart failure.

    abstract:BACKGROUND:Lower urinary sodium concentration (UNa) may reflect impaired renal perfusion, higher neurohormonal activity and diuretic resistance. However, the prognostic impact of UNa in patients with acute heart failure (AHF) has not been fully elucidated. METHODS:We investigate the association between UNa and clinica...

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    pub_type: 杂志文章


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    更新日期:2018-03-01 00:00:00

  • Noninvasive assessment of left ventricular performance following transluminal coronary angioplasty.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Kanemoto N,Hör G,Kober G,Maul FD,Klepzig H Jr,Standke R,Kaltenbach M

    更新日期:1983-06-01 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Takahashi N,Nakagawa M,Saikawa T,Watanabe M,Ooie T,Yufu K,Shigematsu S,Hara M,Sakino H,Katsuragi I,Tanaka K,Yoshimatsu H

    更新日期:2004-09-01 00:00:00

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    authors: Zhao J,Zhou X,Huang J,Chen J,Gu D

    更新日期:2005-04-28 00:00:00

  • The change in concept and surgical treatment on Buerger's disease--personal experience and review.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Nakajima N

    更新日期:1998-10-01 00:00:00

  • Amine-enriched surface modification facilitates expansion, attachment, and maintenance of human cardiac-derived c-kit positive progenitor cells.

    abstract:BACKGROUND:Stem cells have a low expansion rate and are difficult to maintain in vitro. To overcome the problems of cardiovascular regeneration, we developed a novel method of stem cell cultivation in culture vessels with amine and carboxyl coatings. METHODS AND RESULTS:We isolated cardiac stem/progenitor cells from i...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Choi SH,Jung SY,Yoo SM,Asahara T,Suh W,Kwon SM,Baek SH

    更新日期:2013-09-20 00:00:00

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    abstract:PURPOSE:Severe valve lesions require corrective interventions to avoid progression to heart failure (HF) and premature demise. We tested the hypothesis that despite operative risks, corrective valvular interventions will lead to significant improvements in overall cardiac pump function, especially before the onset of c...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Tan DK,Hothi SS,Macdonald W,Schlosshan D,Tan LB

    更新日期:2015-01-01 00:00:00

  • Incidence and impact of renal dysfunction on clinical outcomes after transcatheter aortic valve implantation.

    abstract:BACKGROUND:The impact of baseline renal dysfunction on early and late clinical outcomes after transcatheter aortic valve implantation (TAVI) remains to be defined. METHODS:927 patients included in the prospective Bern TAVI registry were classified on the basis of the baseline estimated glomerular filtration rate (eGFR...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Franzone A,Stortecky S,Pilgrim T,Asami M,Lanz J,Heg D,Langhammer B,Piccolo R,Lee JKT,Praz F,Räber L,Valgimigli M,Roost E,Windecker S

    更新日期:2018-01-01 00:00:00

  • Deterioration of indices of aortic augmentation and vascular age predate major cardiac events and interact with opiate dependence.

    abstract::Pulse wave analysis (PWA) by radial arterial tonometry is receiving increasing attention for the assessment of central vascular compliance in younger patients. We present five PWA studies performed prospectively on a patient with severe coronary artery disease, and find that the measures of central augmented pressure ...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Reece AS

    更新日期:2011-05-19 00:00:00

  • The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair.

    abstract:BACKGROUND:Endothelial dysfunction promotes atherogenesis, vascular inflammation, and thrombus formation. Reendothelialization after angioplasty is required in order to prevent stent failure. Previous studies have highlighted the role of 2-arachidonoylglycerol (2-AG) in murine experimental atherogenesis and in human co...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Jehle J,Eich L,Danisch M,Bagheri S,Avraamidou E,Pfeifer P,Tiyerili V,Bindila L,Lutz B,Nickenig G

    更新日期:2021-01-15 00:00:00

  • ST-segment changes after direct current external cardioversion for atrial fibrillation. Incidence, characteristics and predictive factors.

    abstract:BACKGROUND:Incidence, characteristics and predictive factors of transient ST-segment changes after DC shock are poorly known. METHODS:91 consecutive pts referred for external cardioversion of atrial fibrillation (AF) (61 men, 69±10 yo) were prospectively included. The presence of ST elevation or depression was assesse...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Rumeau P,Fourcade J,Duparc A,Hébrard A,Mondoly P,Rollin A,Massabuau P,Detis N,Elbaz M,Carrié D,Galinier M,Delay M,Maury P

    更新日期:2011-05-05 00:00:00

  • Clinical significance of papillary muscle late enhancement detected via cardiac magnetic resonance imaging in patients with single old myocardial infarction.

    abstract:BACKGROUND:Contrast-enhanced cardiac magnetic resonance imaging (MRI) can depict papillary muscle (PM) necrosis or fibrosis by late enhancement (LE) of PM, but its clinical significance in old myocardial infarction (OMI) has been little understood. METHODS:Myocardial LE and PM-LE were detected with contrast imaging in...

    journal_title:International journal of cardiology

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    authors: Okayama S,Uemura S,Soeda T,Onoue K,Somekawa S,Ishigami K,Watanabe M,Nakajima T,Fujimoto S,Saito Y

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  • Cardiac tamponade as presentation of systemic amyloidosis.

    abstract::We present a patient with pericardial tamponade due to amyloid heart disease. A 64-yr-old man was admitted to the hospital because of fatigue and the abrupt development of chest pain and dyspnea. Echocardiography showed severe pericardial effusion and total pericardiectomy was necessary. Ten months later laboratory st...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Navarro JF,Rivera M,Ortuño J

    更新日期:1992-07-01 00:00:00

  • Atrial septal defect in adults > or =40 years old: negative impact of low arterial oxygen saturation.

    abstract:BACKGROUND:Although good prognosis and clinical long-term outcome have been commonly reported in minimally symptomatic adult patients with ASD, this information has been based on studies with a relatively small number of adult patients. We studied unoperated patients aged over 40 years to define the patterns of present...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Rosas M,Attie F,Sandoval J,Castellano C,Buendía A,Zabal C,Granados N

    更新日期:2004-02-01 00:00:00

  • TGFβ1 contributes to cardiomyogenic-like differentiation of human bone marrow mesenchymal stem cells.

    abstract:BACKGROUND:The majority of the protocols for cardiomyocyte differentiation of MSC use 5-azacytidine as an inducer. As transforming growth factor β1 and 5-azacytidine share similar target signaling pathways, we examined whether transforming growth factor β1 can play a role in cardiac differentiation process in human mes...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Mohanty S,Bose S,Jain KG,Bhargava B,Airan B

    更新日期:2013-02-10 00:00:00

  • Cardiac remodeling rather than disturbed myocardial energy metabolism is associated with cardiac dysfunction in diabetic rats.

    abstract:BACKGROUND:Diabetes mellitus (DM) alters the energy substrate metabolism in the heart and the early sign of diabetic cardiomyopathy is the diastolic dysfunction. Although it is known that the extracellular matrix must be altered in the presence of diabetes, its local regulation has not been fully elucidated. Our aim wa...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Bollano E,Omerovic E,Svensson H,Waagstein F,Fu M

    更新日期:2007-01-08 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: De Smedt D,De Bacquer D,De Sutter J,Dallongeville J,Gevaert S,De Backer G,Bruthans J,Kotseva K,Reiner Ž,Tokgözoğlu L,Clays E

    更新日期:2016-04-15 00:00:00

  • Low serum potassium levels and diabetes - An unfavorable combination in patients with heart failure and preserved ejection fraction.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Badr Eslam R,Öztürk B,Panzer S,Qin H,Duca F,Binder C,Rettl R,Dachs TM,Alasti F,Vila G,Bonderman D

    更新日期:2020-10-15 00:00:00

  • "The attack of the 52 cm lead": an unusual case of late cardiac perforation by a passive-fixation permanent pacemaker lead.

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    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Ramirez MF,Ching CK,Ho KL,Teo WS

    更新日期:2007-01-31 00:00:00

  • Attenuated renal excretory response to atrial natriuretic peptide in congestive heart failure in man.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Eiskjaer H,Bagger JP,Danielsen H,Jensen JD,Jespersen B,Thomsen K,Pedersen EB

    更新日期:1991-10-01 00:00:00

  • Anatomical consideration of the radial artery for transradial coronary procedures: arterial diameter, branching anomaly and vessel tortuosity.

    abstract:BACKGROUND:The radial artery is currently regarded as a useful vascular access site for coronary procedures. Adequate anatomical information of the radial artery should be helpful in performing the transradial coronary procedure. Therefore, we tried to evaluate the size of radial artery, the incidence and clinical sign...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Yoo BS,Yoon J,Ko JY,Kim JY,Lee SH,Hwang SO,Choe KH

    更新日期:2005-06-08 00:00:00

  • Is it time to change how we think about incomplete coronary revascularization?

    abstract::The optimal degree of revascularization for patients with chronic multivessel coronary artery disease remains an unsolved issue. Intuitively, complete revascularization decreases cardiovascular events and improves outcomes compared to incomplete procedures, but in recent years the concept of incomplete revascularizati...

    journal_title:International journal of cardiology

    pub_type: 社论


    authors: Spadaccio C,Nappi F,Nenna A,Beattie G,Chello M,Sutherland FW

    更新日期:2016-12-01 00:00:00