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Atorvastatin attenuates post-implant tissue degeneration of cardiac prosthetic valve bovine pericardial tissue in a subcutaneous animal model.

Abstract：

AIMS:The aim of our study was to examine the effects of statin therapy (atorvastatin) on post-implant structural changes of bovine pericardial tissue in a subcutaneous animal model. METHODS AND RESULTS:Sixty male C57BL/6 mice underwent subcutaneous dorsal implantation of bovine pericardial fragments. Animals were randomized to treatment with atorvastatin (50 mg/kg) (statin group - SG) or to vehicle (control group - CG). After 1.5 months, all fragments were explanted and submitted to histopathological assessment (semi-quantitative analysis) to elucidate extent of inflammatory infiltrate, signs of tissue injury, or presence of microcalcification. Calcium determination of the implanted pericardial tissue was also performed by inductively coupled plasma mass spectrometry (ICP-MS) assessment. ICP-MS analysis showed that pericardial fragments in SG had significantly (p<0.01) less calcium content than CG (625+/-142 vs. 962+/-590 microg/g, respectively). Light microscopy showed marked inflammatory infiltrates and tissue injury of pericardial specimens in CG animals, whereas SG animals maintained a better preserved original pericardial structure. CONCLUSIONS:Our findings indicate that atorvastatin significantly attenuates the post-implant structural degeneration of artificial valve bovine pericardial tissue in a subcutaneous animal model. Further observations are mandatory to assess the effects of statins on the implanted bioprosthetic valve tissue in the blood circulation.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Lorusso R,Corradi D,Maestri R,Bosio S,Curulli A,Beghi C,Gerometta P,Russo C,Gelsomino S,Moreo A,De Cicco G,Rosano G,Volterrani M

doi

10.1016/j.ijcard.2008.11.174

subject

Has Abstract

pub_date

2010-05-14 00:00:00

pages

68-74

issue

1

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(08)01321-1

journal_volume

141

pub_type

杂志文章

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