Abstract:
BACKGROUND:The prognostic value of circulating oxidized low-density lipoprotein (OxLDL) in patients with unstable coronary artery disease (CAD) is unknown. METHODS:Plasma levels of OxLDL were measured in 433 patients with unstable CAD included in FRISC-II (Fragmin and fast Revascularisation in Instability in Coronary artery disease trial) and in 233 of these patients at follow-up 4-7 weeks later. Mortality and myocardial infarction (MI) at 2 years of follow-up was related to above (n=226) or below (n=207) the median level of OxLDL (76 U/L) at study entry. RESULTS:After adjustment for other well-known predictors of risk, OxLDL levels >76 U/L were associated with a higher risk for recurrent MI (Odds Ratio [95% CI]: 1.90 [1.05-3.39]). When patients were divided according to troponin T (TnT) status, the prognostic value of OxLDL was most evident in the TnT negative group with a risk of MI of 16.9% in patients with elevated OxLDL compared to 1.7% (p=0.004) in those without. No association was found between levels of OxLDL and mortality. At follow-up levels of OxLDL were similar to levels during the acute phase unless patients were treated with statins in which levels were significantly lower. CONCLUSIONS:Elevated levels of OxLDL may identify patients with unstable CAD, at increased risk for future MI independent of other risk variables, particularly those without evidence of myocardial damage. OxLDL levels appear to be similar in patients during the unstable and stable phase of CAD unless statin therapy is initiated.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Johnston N,Jernberg T,Lagerqvist B,Siegbahn A,Wallentin Ldoi
10.1016/j.ijcard.2005.11.006subject
Has Abstractpub_date
2006-11-10 00:00:00pages
167-73issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(05)01334-3journal_volume
113pub_type
杂志文章,多中心研究,随机对照试验abstract:BACKGROUND:Patients who have had a prior myocardial infarction (MI) are at increased risk for adverse outcomes after subsequent percutaneous coronary intervention (PCI). OBJECTIVE:The objective of this study is to examine the efficacy and safety of cangrelor, a potent intravenous P2Y12 inhibitor, in patients with prio...
journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:2006-06-16 00:00:00
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pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
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doi:10.1016/j.ijcard.2007.06.017
更新日期:2008-08-01 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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doi:10.1016/j.ijcard.2012.05.055
更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2008-10-30 00:00:00
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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更新日期:1999-10-31 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2013-04-30 00:00:00
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pub_type: 杂志文章,评审
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