Abstract:
INTRODUCTION:We aim to characterize the nature and magnitude of the prospective association between education and incident heart failure (HF) in the Atherosclerosis Risk in Communities (ARIC) Study and investigate any causal relevance to the association between them. METHODS:The final sample size was 12,315 in this study. Baseline characteristics between education levels were compared using 1-way ANOVA test, the Kruskal-Wallis test, or the χ2 test. We used the Kaplan-Meier estimate to compute the cumulative incident of HF by education levels and the difference in estimate was compared using the log-rank test. Cox hazard regression models were used to explore the association between education levels and incident HF. Two-sample Mendelian randomization (MR) based on publicly available summary-level data from genome-wide association studies (GWASs) was used to estimate the causal influence of the education and incident HF. RESULTS:During a median follow-up of 25.1years, 2453 cases (19.9%) of incident HF occurred. After multiple adjustments in the final model, participants in the intermediate and advanced education levels were still associated with 18% and 21% decreased rate of incident HF separately. In MR analysis, we detected a protective causal association between education and HF (P=0.005). CONCLUSIONS:Participants with higher education levels were associated with a decreased rate of incident HF. There was a causal association between education and HF.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Liao LZ,Zhuang XD,Zhang SZ,Liao XX,Li WDdoi
10.1016/j.ijcard.2020.09.068subject
Has Abstractpub_date
2021-02-01 00:00:00pages
115-121eissn
0167-5273issn
1874-1754pii
S0167-5273(20)33898-5journal_volume
324pub_type
杂志文章abstract:OBJECTIVES:To investigate the protective effects of valsartan against smoking-induced left ventricular dysfunction and explore the potential mechanisms involved. METHODS:Rats were randomly divided into 3 groups: smoking group (exposed to cigarette smoke), valsartan group (exposed to cigarette smoke and treated orally ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.03.068
更新日期:2013-08-10 00:00:00
abstract::This study tracks the temporal changes in prevalence of childhood and adolescent overweight and obesity in different regions of China from 1985 to 2005. Using a series data of the Chinese National Survey on Students Constitution and Health, we compared the temporal changes over a 20-year period of the prevalence of ov...
journal_title:International journal of cardiology
pub_type: 社论
doi:10.1016/j.ijcard.2008.07.003
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.12.039
更新日期:2005-08-03 00:00:00
abstract::Isolated pulmonary hypertension with clinical implication is rare in rheumatoid arthritis. We sought to study the prevalence of pulmonary arterial hypertension in an unselected population of 45 patients with rheumatoid arthritis (classified according to the ARA criteria) without cardiac disease and corresponding age a...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.04.084
更新日期:2008-07-21 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.11.261
更新日期:2017-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.06.067
更新日期:2015-10-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.12.045
更新日期:2015-03-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 传,历史文章
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更新日期:2015-03-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2015-02-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.04.005
更新日期:2020-10-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2020-02-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.06.096
更新日期:2016-10-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.03.045
更新日期:2020-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2011.11.018
更新日期:2012-02-23 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.03.043
更新日期:2006-03-08 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.03.176
更新日期:2015-01-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2010.08.032
更新日期:2011-12-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.10.067
更新日期:2018-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2011.06.020
更新日期:2013-03-10 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.11.145
更新日期:2010-05-28 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.04.077
更新日期:2009-07-24 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2014.07.007
更新日期:2014-10-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.01.021
更新日期:2015-03-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.03.001
更新日期:2014-05-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2017.05.059
更新日期:2017-09-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.ijcard.2016.12.047
更新日期:2017-03-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.07.094
更新日期:2007-01-31 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(85)90180-9
更新日期:1985-01-01 00:00:00