当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Cardiac effects of acute exhaustive exercise in a rat model.

Cardiac effects of acute exhaustive exercise in a rat model.

Abstract：

BACKGROUND:The role of physical exercise in the prevention and treatment of cardiovascular diseases has been well described, however, elevations in cardionecrotic biomarkers after prolonged exercise (i.e. ultramarathon running) were observed. We aimed at understanding the biochemical, molecular biological, structural and functional alterations in the heart after exhaustive exercise in a rat model. METHODS:Rats of the exercise group were forced to swim for 3h with 5% body weight (workload) attached to the tail, control rats were taken into the water for 5min. After a 2-hour recovery period we performed left ventricular (LV) pressure-volume analysis to investigate LV function and mechanoenergetics. Additionally, blood and myocardium samples were harvested for biochemical and histological examinations. Gene expression changes were detected by qRT-PCR. RESULTS:When compared to controls, elevated plasma levels of cardiac troponin T and creatine kinase were detected after exhaustive exercise. Histological analysis showed sporadic fragmentation of myocardial structure and leukocyte infiltration in the exercised group. We observed increased end-systolic volume, decreased ejection fraction, impaired contractility (preload recruitable stroke work) and mechanoenergetics (ventriculoarterial coupling, mechanical efficiency) of LV after exercise. Myocardial expression of major antioxidant enzymes was increased along with increased myocardial nitro-oxidative stress. Bax/Bcl-2 ratio and TUNEL staining showed enhanced apoptotic signaling. Exhaustive exercise also resulted in the dysregulation of the matrix metalloproteinase system. CONCLUSIONS:Excessive physical activity has an adverse effect on the heart. The observed functional impairment is associated with increased nitro-oxidative stress, enhanced apoptotic signaling and dysregulation of the matrix metalloproteinase system after exhaustive exercise.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Oláh A,Németh BT,Mátyás C,Horváth EM,Hidi L,Birtalan E,Kellermayer D,Ruppert M,Merkely G,Szabó G,Merkely B,Radovits T

doi

10.1016/j.ijcard.2014.12.045

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

258-66

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(14)02467-X

journal_volume

182

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Intravascular ultrasound assessment of atherosclerotic plaque in the aorta.

    abstract：BACKGROUND:Intravascular ultrasound (IVUS) has been used for assessment of the coronary arteries. However, few IVUS studies have been reported on the aorta. MATERIALS AND METHODS:To assess the presence of atherosclerotic disease in the aorta by the use of IVUS, 29 patients with heart disease (24 men and 5 women; mean ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2006.12.012

    authors： Tamiya E,Sone M,Koizumi A,Inoue K,Koide H,Maruyama S,Nishizawa H,Daida H

    更新日期：2008-01-24 00:00:00

  • Life course socioeconomic conditions, adulthood risk factors and cardiovascular mortality among men and women: a 17-year follow up of the GLOBE study.

    abstract：BACKGROUND:Our goal was to study associations between childhood socioeconomic position (SEP), adulthood SEP, adulthood risk factors and cardiovascular disease (CVD) mortality, by investigating the critical period and pathway models. METHODS:The prospective GLOBE study in the Netherlands, with baseline data from 1991, ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2013.01.219

    authors： Kamphuis CB,Turrell G,Giskes K,Mackenbach JP,van Lenthe FJ

    更新日期：2013-10-03 00:00:00

  • Efficacy of antibacterial envelope in prevention of cardiovascular implantable electronic device infections in high-risk patients: A systematic review and meta-analysis.

    abstract：BACKGROUND:Limited evidence is available to determine the efficacy of an antibacterial enveloped (AE) cardiovascular implantable electronic device (CIED). OBJECTIVE:To assess if the use of antibacterial enveloped devices in high-risk patients are associated with lower chances of major CIED infections and mortality com...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.03.042

    authors： Ullah W,Nadeem N,Haq S,Thelmo FL Jr,Abdullah HM,Haas DC

    更新日期：2020-09-15 00:00:00

  • Association between time of out-of-hospital cardiac arrest and survival: Examination of the all-Japan Utstein registry and comparison with the 2005 and 2010 international resuscitation guidelines.

    abstract：BACKGROUND:Existing studies have yielded conflicting results regarding the relationship between the time of occurrence of out-of-hospital cardiac arrests and the associated outcomes. We examined whether the one-month survival rate for out-of-hospital cardiac arrests differed depending on whether the cardiac arrest occu...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.09.043

    authors： Kato K,Otsuka T,Seino Y,Tahara Y,Yonemoto N,Nonogi H,Nagao K,Ikeda T,Sato N,Tsutsui H,Japanese Circulation Society with Resuscitation Science Study (JCS-ReSS) Group.

    更新日期：2021-02-01 00:00:00

  • Decline in risk of recurrent cardiovascular events in the period 1996 to 2014 partly explained by better treatment of risk factors and less subclinical atherosclerosis.

    abstract：BACKGROUND:To quantify the decline in recurrent major cardiovascular events (MCVE) risk in patients with clinically manifest vascular disease between 1996 and 2014 and to assess whether the improvements in recurrent MCVE-risk can be explained by reduced prevalence of risk factors, more medication use and less subclinic...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.07.026

    authors： Berkelmans GFN,van der Graaf Y,Dorresteijn JAN,de Borst GJ,Cramer MJ,Kappelle LJ,Westerink J,Visseren FLJ,SMART study group.

    更新日期：2018-01-15 00:00:00

  • Biventricular myocardial adaptation to different training protocols in competitive master athletes.

    abstract：BACKGROUND:Conflicting data have been reported about the nature (physiologic versus pathologic) of left ventricular (LV) hypertrophy in master athletes. AIM OF THE STUDY:To analyze LV and right ventricular (RV) myocardial function in master athletes with LV hypertrophy induced by either endurance or strength training....

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2006.03.041

    authors： D'Andrea A,Caso P,Scarafile R,Salerno G,De Corato G,Mita C,Di Salvo G,Allocca F,Colonna D,Caprile M,Ascione L,Cuomo S,Calabrò R

    更新日期：2007-02-14 00:00:00

  • Effectiveness of a management program for outpatient clinic or remote titration of beta-blockers in CRT patients: The RESTORE study.

    abstract：BACKGROUND:Many patients fail to receive β-blockers before cardiac resynchronization therapy defibrillator (CRT-D) implantation, or receive them at a suboptimal dose, and require optimization after implantation. We assessed the effectiveness of a structured program for β-blocker titration in CRT-D patients followed up ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2017.02.015

    authors： D'Onofrio A,Palmisano P,Rapacciuolo A,Ammendola E,Calò L,Ruocco A,Bianchi V,Maresca F,Del Giorno G,Martino A,Mauro C,Campari M,Valsecchi S,Accogli M

    更新日期：2017-06-01 00:00:00

  • Vasculoprotective properties of enhanced external counterpulsation for coronary artery disease: beyond the hemodynamics.

    abstract：:A growing pool of evidence has shown that enhanced external counterpulsation (EECP) is a non-invasive, safe, low-cost, and highly beneficial therapy for patients with coronary artery disease. However, the exact mechanisms of benefit exerted by EECP therapy remain only partially understood. The favorable hemodynamic ef...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2012.04.003

    authors： Yang DY,Wu GF

    更新日期：2013-06-05 00:00:00

  • Correlation between symptomatology and site of acute myocardial infarction.

    abstract：OBJECTIVE:We determined the occurrence of presenting symptoms in patients with different sites of acute myocardial infarction after controlling for age and conventional risk factors. METHODS:Hospital-based study of patients hospitalized because of first anterior (n=731), inferior (n=719) and lateral (n=96) infarction ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(00)00414-9

    authors： Culić V,Mirić D,Eterović D

    更新日期：2001-02-01 00:00:00

  • Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers reduced dementia risk in patients with diabetes mellitus and hypertension.

    abstract：OBJECTIVE:The effects of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) on dementia risk in patients with type 2 diabetes mellitus (DM) and hypertension remain unknown. We investigated the effects of ACEIs and ARBs on dementia risk in patients with type 2 DM and hypertension....

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.06.215

    authors： Kuan YC,Huang KW,Yen DJ,Hu CJ,Lin CL,Kao CH

    更新日期：2016-10-01 00:00:00

  • Cardiac troponin elevation predicts all-cause mortality in patients with acute exacerbation of chronic obstructive pulmonary disease: Systematic review and meta-analysis.

    abstract：BACKGROUND:Cardiovascular disease, especially ischemic heart disease, is a major comorbidity in chronic obstructive pulmonary disease (COPD) patients. Several studies suggested that after acute exacerbation of COPD (AECOPD), there is a significant increase of mortality (cardiac and all-cause) and of myocardial infarcti...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijcard.2015.05.006

    authors： Pavasini R,d'Ascenzo F,Campo G,Biscaglia S,Ferri A,Contoli M,Papi A,Ceconi C,Ferrari R

    更新日期：2015-07-15 00:00:00

  • Impact of cytochrome P450 2C19 loss-of-function polymorphism on intra-stent thrombi and lesion outcome after everolimus-eluting stent implantation compared to that after first-generation drug-eluting stent implantation.

    abstract：BACKGROUND:The contribution of clopidogrel response due to cytochrome P450 (CYP) 2C19 loss-of-function polymorphism after drug-eluting stent (DES) implantation is unclear. METHODS:A total of 196 patients who had undergone optical coherence tomography (OCT) at 8 months following first-generation DES (120 lesions) and c...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.11.068

    authors： Konishi A,Shinke T,Otake H,Nishio R,Sawada T,Takaya T,Nakagawa M,Osue T,Taniguchi Y,Iwasaki M,Kinutani H,Masaru K,Takahashi H,Terashita D,Shite J,Hirata K

    更新日期：2015-01-20 00:00:00

  • Pathophysiology of acute coronary syndromes in the elderly.

    abstract：:Elderly patients represent an important proportion of the acute coronary syndrome (ACS) population. Furthermore, this group of ACS patients is continuously growing because of the progressive ageing of the population. The ageing process implies marked changes in patient physiology that directly impact in their risk. Ho...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2016.07.205

    authors： Badimon L,Bugiardini R,Cubedo J

    更新日期：2016-11-01 00:00:00

  • Long-term use of angiotensin II receptor blockers and risk of cancer: a population-based cohort analysis.

    abstract：BACKGROUND:The risk of incident cancer after angiotensin II receptor blockers (ARBs) exposure was controversially reported by analyses of clinical trials and database. We assessed the occurrence of overall and site-specific cancers among ARB users and nonusers in the cohort with indications for ARB treatment. METHODS:...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.05.096

    authors： Wang KL,Liu CJ,Chao TF,Huang CM,Wu CH,Chen TJ,Chiang CE

    更新日期：2013-09-01 00:00:00

  • Hydatid disease of the right ventricle and role of tomographic scanning in its diagnosis.

    abstract：:A case of hydatid cyst affecting the right ventricle is described and role of tomographic scanning highlighted as it demonstrated a typical multilocular cyst arising from the right ventricle in the patient discussed here. ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(91)90075-z

    authors： Akhtar MJ

    更新日期：1991-12-01 00:00:00

  • Subclinical atherosclerosis in asymptomatic carriers of persistent antiphospholipid antibodies positivity: A cross-sectional study.

    abstract：BACKGROUND:Whereas the relationship between subclinical atherosclerosis and antiphospholipid syndrome (APS) has been widely investigated, little is known about subclinical atherosclerosis in asymptomatic carriers with isolated antiphospholipid antibodies positivity (APP). METHODS:Consecutive APP carriers, APS subjects...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.06.010

    authors： Di Minno MND,Emmi G,Ambrosino P,Scalera A,Tufano A,Cafaro G,Peluso R,Bettiol A,Di Scala G,Silvestri E,Prisco D

    更新日期：2019-01-01 00:00:00

  • Variable effects of anti-diabetic drugs in animal models of myocardial ischemia and remodeling: a translational perspective for the cardiologist.

    abstract：:Diabetes and heart failure are very prevalent, and affect each other's incidence and severity. Novel therapies to reduce post-myocardial infarction (MI) remodeling that progresses into heart failure are urgently needed, especially in diabetic patients. Clinical studies have suggested that some oral anti-diabetic agent...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2013.10.005

    authors： Yin M,Westenbrink BD,Meissner M,van Gilst WH,de Boer RA

    更新日期：2013-11-30 00:00:00

  • Failed thrombolysis in myocardial infarction.

    abstract：:Prompt treatment with thrombolytic therapy in acute myocardial infarction has been proven to reduce infarct size and mortality. However, reperfusion fails to occur in 30-50% of patients, either due to impaired epicardial artery flow or microvascular occlusion, with these patients experiencing a higher morbidity and mo...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0167-5273(00)00282-5

    authors： Qasim A,Chauhan A,More RS

    更新日期：2000-08-01 00:00:00

  • Interpretation of elevated high-sensitivity cardiac troponin I in elite soccer players previously infected by severe acute respiratory syndrome coronavirus 2.

    abstract：OBJECTIVES:To clarify the meaning of elevated cardiac troponin in elite soccer athletes previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and screened for cardiovascular involvement in the wake of competitive sport resumption. METHODS:We designed a retrospective cohort study with th...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.11.039

    authors： Mascia G,Pescetelli F,Baldari A,Gatto P,Seitun S,Sartori P,Pieroni M,Calò L,Della Bona R,Porto I

    更新日期：2020-11-23 00:00:00

  • Pathological importance of anti-G-protein coupled receptor autoantibodies.

    abstract：:Anti-cardiac receptor autoantibodies have been studied intensively last 10 years. A growing evidence, both in vitro and in vivo and both clinical and experimental studies, have supported that these anti-cardiac receptor autoantibodies, mainly anti-beta1 adrenoceptor autoantibodies, play a very important pathophysiolog...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2006.05.013

    authors： Matsui S,Fu M

    更新日期：2006-09-10 00:00:00

  • Stroke risk reduction with oral anticoagulation using CHA2DS2-VASc in a Japanese AF population: A modeling analysis.

    abstract：BACKGROUND:Current clinical guidelines recommend that risk stratification for ischaemic stroke in patients with nonvalvular AF (NVAF) should be performed using the CHA2DS2-VASc score (Congestive heart failure, Hypertension, Age≥ 75years [double], Diabetes mellitus, previous thromboembolism [double], Vascular disease, A...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.11.196

    authors： Senoo K,Lane DA,Lip GY

    更新日期：2015-02-15 00:00:00

  • Progression of venoconstriction in patients after heart transplantation during exercise.

    abstract：:Changes of both central hemodynamics and peripheral circulation in non-exercising muscle were investigated in 17 patients after successful orthotopic heart transplantation during moderate supine isotonic leg-exercise. Changes of peripheral circulation were measured in 14 healthy controls. The cardiac output rose from ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(94)90288-7

    authors： Petrasko M,Horak J,Prerovsky I

    更新日期：1994-05-01 00:00:00

  • Acute and chronic effects of ramipril and captopril in congestive heart failure.

    abstract：:We studied the acute and long-term effects of ramipril and captopril in 12 patients with moderate to severe congestive heart failure using an open, parallel design. Drug doses were titrated. Compared with baseline values, maximal haemodynamic and humoral effects after the first dose of both angiotensin converting enzy...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0167-5273(89)90330-6

    authors： de Graeff PA,Kingma JH,Viersma JW,Wesseling H,Lie KI

    更新日期：1989-04-01 00:00:00

  • Comparison of two different sampling intervals for optical coherence tomography evaluation of neointimal healing response after coronary stent implantation.

    abstract：BACKGROUND/OBJECTIVES:Optical coherence tomography (OCT) is widely used for evaluation of healing response to stent implantation. We sought to test the agreement between the 1-mm and 0.6-mm sampling intervals for assessment of the percentage of uncovered and malapposed struts by OCT. METHODS:Thirty-eight patients pres...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ijcard.2016.11.173

    authors： Varho V,Nammas W,Kiviniemi TO,Sia J,Romppanen H,Pietilä M,Airaksinen JK,Karjalainen PP

    更新日期：2017-01-15 00:00:00

  • Five-year changes in cardiac structure and function in patients with rheumatoid arthritis compared with the general population.

    abstract：BACKGROUND:Patients with rheumatoid arthritis (RA) have increased risk of heart failure with preserved ejection fraction. The development and progression of left ventricular dysfunction before onset of clinical heart failure are unknown. The objective of this study was to evaluate longitudinal changes in cardiac struct...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.03.108

    authors： Davis JM 3rd,Lin G,Oh JK,Crowson CS,Achenbach SJ,Therneau TM,Matteson EL,Rodeheffer RJ,Gabriel SE

    更新日期：2017-08-01 00:00:00

  • Clinical predictors of cardiac events in patients with isolated syncope and negative electrophysiologic study.

    abstract：BACKGROUND:Patients with syncope or near syncope of unknown etiology represent a great challenge to cardiologists. An initial symptomatic episode triggers a series of diagnostic analysis which remain unsatisfactory when negative. More invasive tools such as electrophysiologic testing yield only partial answers to risk ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2005.05.025

    authors： Da Costa A,Gulian JL,Romeyer-Bouchard C,Messier M,Zarqane N,Samuel B,Khiel A,Isaaz K

    更新日期：2006-04-28 00:00:00

  • First in man prolonged pressure-controlled intermittent coronary sinus occlusion to treat refractory left ventricular dysfunction and ischemia with patent epicardial coronary arteries.

    abstract：AIMS:Pressure-controlled Intermittent Coronary Sinus Occlusion (PICSO) intermittently increases the pressure in the cardiac venous outflow tract using a balloon-tipped catheter introduced percutaneously into the coronary sinus. It aims to improve microvascular perfusion in STEMI patients during PCI, thus improving infa...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2017.05.030

    authors： Pappalardo F,Ancona MB,Giannini F,Regazzoli D,Mangieri A,Montorfano M,De Bonis M,Alfieri O,Zangrillo A,Scandroglio AM,Colombo A,Latib A

    更新日期：2017-08-15 00:00:00

  • Cardiovascular magnetic resonance-derived intramyocardial hemorrhage after STEMI: Influence on long-term prognosis, adverse left ventricular remodeling and relationship with microvascular obstruction.

    abstract：BACKGROUND:T2 weighted cardiovascular magnetic resonance (CMR) can detect intramyocardial hemorrhage (IMH) after ST-elevation myocardial infarction (STEMI). The long-term prognostic value of IMH beyond a comprehensive CMR assessment with late enhancement (LE) imaging including microvascular obstruction (MVO) is unclear...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.05.055

    authors： Husser O,Monmeneu JV,Sanchis J,Nunez J,Lopez-Lereu MP,Bonanad C,Chaustre F,Gomez C,Bosch MJ,Hinarejos R,Chorro FJ,Riegger GA,Llacer A,Bodi V

    更新日期：2013-09-01 00:00:00

  • Peripheral artery disease and outcomes after myocardial infarction: an individual-patient meta-analysis of 28,771 patients in CAPRICORN, EPEHESUS, OPTIMAAL and VALIANT.

    abstract：OBJECTIVES:To examine the prevalence of peripheral artery disease (PAD) and the relationship between PAD and cardiovascular (CV) outcomes in subjects with left ventricular systolic dysfunction, heart failure or both after acute myocardial infarction (MI). BACKGROUND:PAD is associated with poorer prognosis in patients ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijcard.2012.11.033

    authors： Inglis SC,Bebchuk J,Al-Suhaim SA,Case J,Pfeffer MA,Solomon SD,Hou YR,Pitt B,Dargie HJ,Ford I,Kjekshus J,Zannad F,Dickstein K,McMurray JJ

    更新日期：2013-09-30 00:00:00

  • Responses of vascular smooth muscle cells to estrogen are dependent on balance between ERK and p38 MAPK pathway activities.

    abstract：OBJECTIVE:To investigate the mechanisms underlying the dual effects of estrogen on vascular smooth muscle cells (VSMC). METHODS:MTT assay, ELISA, flow cytometry and Western analysis were used to investigate the effects of 17beta-estradiol (E(2)) on proliferation, apoptosis, cell cycle progression, ERK and p38 activiti...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2008.02.017

    authors： Cheng B,Song J,Zou Y,Wang Q,Lei Y,Zhu C,Hu C

    更新日期：2009-05-29 00:00:00