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Long-term use of angiotensin II receptor blockers and risk of cancer: a population-based cohort analysis.

Abstract：

BACKGROUND:The risk of incident cancer after angiotensin II receptor blockers (ARBs) exposure was controversially reported by analyses of clinical trials and database. We assessed the occurrence of overall and site-specific cancers among ARB users and nonusers in the cohort with indications for ARB treatment. METHODS:Data were obtained from the Taiwan National Health Insurance research database. Subjects exposed to ARBs ≥ 180 days with no cancer prior to the first year of ARB initiation were identified; age-, sex-, comorbidity- and time-matched nonusers without cancer before the index date plus 1 year were selected. Incidences of overall and the most common cancers between users and nonusers were compared. RESULTS:There were 42,921 subjects enrolled in each group. During the mean follow-up of 4.8 ± 2.4 years, the cumulative incidence of cancer was 4% (ARB users) and 6% (ARB nonusers) (hazard ratio: 0.58, 95% confidence intervals 0.55-0.62; P<0.001). All ARBs significantly correlated with lower rates of cancer. Malignancies from the 7 most common sites were fewer in ARB users with the relative risk reduction of 28 to 49%. ARBs were associated with a decrease in incident cancer across subgroups including prior and concomitant exposure to angiotensin-converting enzyme inhibitors. CONCLUSIONS:In the cohort with indications for ARB treatment, exposure to ARBs was associated with lower risk of overall and site-specific cancers compared to nonusers. These findings reassure the safety of ARBs and support further investigations on ARBs and cancer prevention at the molecular level.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Wang KL,Liu CJ,Chao TF,Huang CM,Wu CH,Chen TJ,Chiang CE

doi

10.1016/j.ijcard.2012.05.096

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

2162-6

issue

5

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(12)00743-7

journal_volume

167

pub_type

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