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Prevalance of anemia and its association with cardio-renal syndrome.

Abstract：

BACKGROUND:Anemia is common in cardio-renal syndrome and may contribute to increase mortality. OBJECTIVE:To examine the prevalence of anemia and its relationship with cardio-renal syndrome, and to evaluate the risk factors for death. METHODS:Retrospective study with all patients admitted with congestive heart failure (CHF). The parameters as age, gender, hemoglobin (Hb), estimated glomerular filtration rate (eGFR), New York Heart Association (NYHA) functional class, ejection fraction (EF%), hospital stay, hypertension, diabetes, smoking and CHF etiology were analyzed. Anemia was defined as Hb<12 g/dL, systolic dysfunction EF<55% and renal failure was stratified according to K-DOQI classification. Statistical analysis was done by the programs EpiInfo and SPSS for windows. RESULTS:A total of 174 patients were studied. The average age was 63+/-16 years, 65.5% were males, and 18 of them (11%) were non-survivors. Anemia was observed in 45% of patients, and 82% presented some degree of renal failure. The majority of patients (87%) were classified as NYHA functional class III or IV. The average ejection fraction was 43.9+/-16.6%, and there was no difference between survivors and non-survivors (p>0.05). Mortality was not significantly higher among patients with anemia (12.4%) when comparing to those without anemia (8.3%, p=0.31). There was a progressive decrease in the level of hemoglobin as renal function decreased (p<0.05). Increased serum creatinine was a significant risk factor for death (OR=1.59, 95% CI=1.074-2.363, p=0.021), and increased EF% was a protection factor against development of death (OR=0.904, 95% CI=0.845-0.973, p=0.007). CONCLUSIONS:The prevalence of anemia is high among patients with cardio-renal syndrome but was not associated with increased mortality. Increased serum creatinine and low EF% were variables associated with death.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Silva RP,Barbosa PH,Kimura OS,Sobrinho CR,Sousa Neto JD,Silva FA,Silva Júnior GB,Mota RM,Daher EF

doi

10.1016/j.ijcard.2006.10.005

subject

Has Abstract

pub_date

2007-08-21 00:00:00

pages

232-6

issue

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(06)01354-4

journal_volume

120

pub_type

杂志文章

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Prevalance of anemia and its association with cardio-renal syndrome.