Abstract:
BACKGROUND:Several hemodynamic measures have been used for optimization of the AV delay of cardiac resynchronization therapy (CRT), including pulse pressure (PP), systolic blood pressure (SBP) and cardiac output (CO). We aimed to determine whether these measures identify the same optimum and whether they have the same efficiency and reproducibility at identifying this optimum. METHODS AND RESULTS:In 22 patients with cardiac resynchronization therapy, we adjusted the AV delay while atrially pacing at 110 bpm and simultaneously recording SBP, diastolic blood pressure (DBP), PP, mean arterial pressure (MAP) and CO. SBP, PP and CO all had essentially the same signal-to-noise ratios (15.4+/-5.4, 15.5+/-6.4, 15.3+/-7.4 respectively p=NS). In contrast, MAP and DBP had significantly worse signal-to-noise ratios than SBP (14.2+/-5.6, p=0.003 and 12.1+/-4.4, p<0.0001 respectively). The optimal AV delay was very similar between SBP, PP, MAP and DBP. For example, the optima identified by SBP correlated strongly with those identified by PP (r=0.94), MAP (r=0.96) and DBP (r=0.90). In contrast, the optima detected by CO was poorly related to these (e.g. r=0.36 with SBP optima). Reproducibility was best for optima detected by SBP followed by MAP and PP. CONCLUSIONS:Essentially the same AV optimum is identified, regardless of whether the parameter chosen for maximization is SBP, PP, MAP or DBP. We conclude that optimizing the CRT AV delay using SBP gives the best combination of efficiency and reproducibility, with PP and MAP being reasonable alternatives.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Whinnett ZI,Davies JE,Nott G,Willson K,Manisty CH,Peters NS,Kanagaratnam P,Davies DW,Hughes AD,Mayet J,Francis DPdoi
10.1016/j.ijcard.2007.08.004subject
Has Abstractpub_date
2008-09-26 00:00:00pages
216-26issue
2eissn
0167-5273issn
1874-1754pii
S0167-5273(07)01486-6journal_volume
129pub_type
杂志文章abstract:BACKGROUND:Reciprocal relationships between endothelial dysfunction and insulin resistance imply that improvement in endothelial dysfunction will have beneficial metabolic consequences. We hypothesized that amlodipine therapy in hypertensive subjects will improve endothelial dysfunction and metabolic parameters. METHO...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2007.11.058
更新日期:2009-03-20 00:00:00
abstract:BACKGROUND:This study sought to compare cardiac magnetic resonance imaging (CMR) with dual source computed tomography (DSCT) for analysis of aortic root dimensions prior to transcatheter aortic valve implantation (TAVI). In addition, the potential impact of CMR and DSCT measurements on TAVI strategy defined by 2D-trans...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ijcard.2011.01.044
更新日期:2012-07-26 00:00:00
abstract:BACKGROUND:Therapeutic and prognostic implications of subclinical thyroid dysfunction in patients with heart failure (HF) are unclear. We compared the prognostic impact of euthyroidism, subclinical thyroid dysfunction, and euthyroid sick syndrome (ESS) in systolic HF. METHODS:We included 1032 patients hospitalized for...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2012.09.064
更新日期:2013-09-20 00:00:00
abstract:BACKGROUND:There is a controversy surrounding the correlation between fibrinogen (Fib) level and prognosis of coronary artery disease (CAD). We try to investigate the role of the subtypes of CAD in this controversy. METHODS:A retrospective analysis was conducted from a single center CAD registered database. 3020 conse...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.07.160
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The usual diagnostic work-up of chest pain patients includes clinical risk profiling and exercise-ECG, possibly followed by additional tests. Recently cardiac computed tomographic angiography (CCTA) has been employed. We evaluated the prognostic value of the combined use of exercise-ECG and CCTA for the deve...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2011.12.016
更新日期:2013-07-15 00:00:00
abstract::We describe an asymptomatic patient with multiple fistulae between coronary arteries and the main pulmonary artery with an insignificant left-to-right shunt. Possible embryological basis of this anomaly is discussed. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(87)90274-9
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Early detection in patients with hypertrophic cardiomyopathy (HCM) is very important. Integrated backscatter (IB) provides a useful noninvasive measure of the acoustic properties of the myocardium, and may detect early myocardial changes. METHODS:Thirty-four carriers who had gene mutations causing HCM were ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.11.009
更新日期:2005-09-30 00:00:00
abstract::Half a century after the elucidation of its molecular structure, aldosterone is generating the greatest interest, not in the fields of endocrinology or renal medicine but in cardiology-where aldosterone over-activation is now perceived as detrimental in heart failure (HF) and ischaemic heart disease. Clinically, exces...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2004.05.004
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia found in clinical practice. We combined high-resolution two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) to compare the atrial proteome of subjects with AF versus controls with sinus rhythm (SR). Our aim was to identify novel...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.04.036
更新日期:2011-08-04 00:00:00
abstract:BACKGROUND:Inspiratory muscle weakness has been described in patients with congestive heart failure (CHF), and only recently in patients with idiopathic pulmonary arterial hypertension. However, the relationship between pulmonary hemodynamics and respiratory muscle function has not been investigated in patients with CH...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2010.04.006
更新日期:2011-07-15 00:00:00
abstract::The Ross procedure has been considered in children as an optimal surgical procedure due to potential growth of the aortic annulus, lack of anticoagulation requirement, very low morbidity rate and excellent survival. Five-hundred-thirty-six (366 male, mean age 29.4 ± 11.1 years) underwent Ross procedure between 1990 an...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.07.009
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Contrast-enhanced cardiac magnetic resonance imaging (MRI) can depict papillary muscle (PM) necrosis or fibrosis by late enhancement (LE) of PM, but its clinical significance in old myocardial infarction (OMI) has been little understood. METHODS:Myocardial LE and PM-LE were detected with contrast imaging in...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.04.037
更新日期:2011-01-07 00:00:00
abstract:BACKGROUND:Noninvasive assessment of coronary plaque is important for coronary risk stratification. Whereas integrated backscatter intravascular ultrasound (IB-IVUS) has proven effective for analysis of the tissue components of coronary plaque, plaque assessment by 64-slice multidetector computed tomography (MDCT) has ...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ijcard.2010.04.002
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:Clinical impact of the minimally invasive surgical mitral valve annuloplasty (MVA) of functional mitral regurgitation (FMR) in systolic heart failure on top of the state-of-the-art standards of care remains controversial. Therefore, we aimed to compare clinical outcomes of isolated MVA using the mini-invasiv...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.06.029
更新日期:2017-10-01 00:00:00
abstract::Antiarrhythmic drugs may aggravate or induce ventricular arrhythmia. The induction of a supraventricular tachycardia or its facilitation has rarely been reported. The purpose of the study was to know whether the potential for supraventricular proarrhythmic effect of a class Ia intravenous antiarrhythmic drug can be ex...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(92)90155-v
更新日期:1992-02-01 00:00:00
abstract::Congenital coronary sinus anomalies are unusual and they rarely coexist with accessory atrioventricular pathways. These anomalies are generally asymptomatic, however they can cause difficulty in mapping. The association between accessory pathway and coronary sinus anomalies may suggest an embryologic link. In this cas...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/S0167-5273(03)00152-9
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVES:Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). The role of the NADPH oxidase (NOX) signaling in the setting of DM and the potential benefits of apocynin on diabetic atrial remodeling remain unknown. METHODS:Sixty Japanese rabbits were randomized into 3 groups as follows: ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.07.132
更新日期:2016-10-15 00:00:00
abstract::Cerebral haemorrhage in anticoagulated patients with mechanical valvular prosthesis poses an uncommon but difficult management problem. Four such patients are presented: one patient had delayed haemorrhagic transformation of a preexisting cerebral infarct, one probably had de novo haemorrhage complicating hypertension...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(91)90005-a
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:In the past diabetes was strongly associated with elevated mortality rate after acute coronary syndrome (ACS). Over the past decade a treatment of the ACS has evolved rapidly with major advances in the management techniques. The aim of the present study was to compare temporal trends of the outcom...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.10.116
更新日期:2015-01-20 00:00:00
abstract::The PossisR polytetrafluoroethylene Permaflow is a synthetic coronary graft which incorporates a Venturi resistor and which is anastomosed to the superior vena cava. Multiple anastomoses to the coronary vessels can be established in sequence until the graft is finally connected to the aorta. This aortocaval fistula en...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(95)02412-p
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Despite several case reports of sirolimus-eluting stent (SES) fracture and concern regarding restenosis after successful SES implantation, the clinical characteristics of this problem are not well known. METHODS:Clinical records and angiographic films of patients who received follow-up coronary angiography ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.10.059
更新日期:2009-01-09 00:00:00
abstract::The differentiation of viable from non viable myocardium is a key issue in the current era of revascularization. Several methods have been used to assess myocardial viability. The radionuclide detection of dysfunctional but viable myocardium depends upon the use of radiotracers whose uptake and trapping are related to...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00066-7
更新日期:1998-05-29 00:00:00
abstract::Heart muscle involvement associated with human immunodeficiency virus (HIV) infection may present as myocarditis, dilated cardiomyopathy or as isolated left or right ventricular dysfunction. Histopathological and ultra structural findings with different degrees of cardiac-chamber dilation have been described and an im...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.12.207
更新日期:2011-02-03 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most frequently encountered arrhythmia in the clinical setting. However, a comprehensive investigation of the molecular mechanism of AF has not been performed. The aim of this study was to clarify transcriptional profiling of genes modulated in the atrium of AF patients using ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.05.026
更新日期:2005-07-10 00:00:00
abstract::We examined the effects of aspirin on human immunocyte adherence to human saphenous vein preparations in vitro. Monocytes and granulocytes were analyzed by phase-contrast microscopy in conjunction with a time-lapse video recording system for cell counting in the medium. Saphenous vein samples taken from five volunteer...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(98)00033-3
更新日期:1998-04-30 00:00:00
abstract::We describe the case of a young female patient with syncope due to complex arrhythmias associated with Prinzmetal's angina. The clinical situation was reproduced by the cold pressor test. ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.12.076
更新日期:2010-08-06 00:00:00
abstract:OBJECTIVE:A number of observations suggest that cytokines may be important modulators in the ventricular remodeling process. It is unclear whether carvedilol modulates myocardial pro-inflammatory and anti-inflammatory cytokines expression. We hypothesized that carvedilol could improve ventricular remodeling partly thro...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.08.065
更新日期:2006-08-10 00:00:00
abstract:BACKGROUND:The prevalence of coronary artery disease (CAD) among Bangladeshis greatly exceeds that of Caucasians. Bangladeshis also suffer from premature onset, clinically aggressive and angiographically extensive disease. The role of conventional CAD risk factors (CCRFs) has been questioned. We therefore sought to det...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.12.175
更新日期:2011-01-21 00:00:00
abstract::Patients with dyslipidemia are at increased risk of coronary heart disease (CHD), while treatment to reduce low density lipoprotein cholesterol (LDL-C) concentrations lessens this risk. Consequently, the Lipid Treatment Assessment Project (L-TAP) was undertaken in the US to determine the extent to which primary care p...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(99)00108-4
更新日期:2000-06-30 00:00:00
abstract:BACKGROUND:Elevated plasma B-type natriuretic peptide (BNP) levels suggest a high risk for future onset of cardiovascular events including congestive heart failure (CHF) and mortality. In the general population, although median plasma BNP levels have been reported to be higher in women than in men, the incidence of CHF...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.01.076
更新日期:2010-08-20 00:00:00