Cerebral haemorrhage in anticoagulated patients with non-septic mechanical valvular prosthesis.

Abstract:

:Cerebral haemorrhage in anticoagulated patients with mechanical valvular prosthesis poses an uncommon but difficult management problem. Four such patients are presented: one patient had delayed haemorrhagic transformation of a preexisting cerebral infarct, one probably had de novo haemorrhage complicating hypertension and in two patients cerebral haemorrhage was associated with excessive anticoagulation. Conservative management including the use of fresh frozen plasma, delayed heparinisation and warfarinisation was used. Both patients with anticoagulant overdose died as a result of extensive haemorrhage despite the drainage of cerebellar haematoma in one patient. The remaining two patients survived with minimal neurological deficits. Diagnosis of the underlying cause of cerebral haemorrhage, and the timing of heparinisation and anticoagulation are discussed.

journal_name

Int J Cardiol

authors

Lau CP,Chang CM,Lau GK,Wong CK,Fong PC,Yu YL

doi

10.1016/0167-5273(91)90005-a

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

289-96

issue

3

eissn

0167-5273

issn

1874-1754

pii

0167-5273(91)90005-A

journal_volume

30

pub_type

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