Amlodipine improves endothelial function and metabolic parameters in patients with hypertension.


BACKGROUND:Reciprocal relationships between endothelial dysfunction and insulin resistance imply that improvement in endothelial dysfunction will have beneficial metabolic consequences. We hypothesized that amlodipine therapy in hypertensive subjects will improve endothelial dysfunction and metabolic parameters. METHODS:Amlodipine (10 mg daily for 8 weeks) or placebo was given to each 45 patients with mild to moderate hypertension in a randomized, double-blind, placebo-controlled, and parallel study. Age, sex, and body mass index were matched. RESULTS:Amlodipine therapy significantly reduced systolic and diastolic blood pressure and increased HDL-cholesterol to greater extent than placebo therapy (all P<0.001). Amlodipine therapy significantly improved flow-mediated dilator response to hyperemia and reduced plasma malondialdehyde levels to a greater extent than placebo (P<0.001 and P=0.035). Amlodipine therapy significantly increased plasma adiponectin levels (P=0.009) and decreased plasma leptin and resistin levels (P<0.001 and P=0.025, respectively) to a greater extent than placebo. Correlations were noted between percent changes in adiponectin levels and percent changes in HDL-cholesterol (r=0.348, P=0.019) and QUICKI (r=0.326, P=0.029) following amlodipine therapy. Only changes in HDL-cholesterol (beta=0.469, P=0.019) and QUICKI (beta=1.786, P=0.069) were independent predictors of changes in adiponectin levels (multivariate regression analysis). We also observed inverse correlations between percent changes in leptin levels and percent changes in QUICKI (r=-0.569, P<0.001) following amlodipine therapy with changes in QUICKI (beta=1.810, P<0.001) as an independent predictor of changes in leptin levels. CONCLUSIONS:Amlodipine therapy improves blood pressure, endothelial function, and metabolic parameters in patients with hypertension.


Int J Cardiol


Koh KK,Han SH,Ahn JY,Chung WJ,Lee Y,Shin EK




Has Abstract


2009-03-20 00:00:00














  • The impact of a 21-day ultra-endurance ride on the heart in young, adult and older adult recreational cyclists.

    abstract:BACKGROUND:This study assessed the acute effect of 21 days of challenging exercise on heart structure and function in recreationally active people across a range of age categories. METHODS:15 recreationally active people completed a 21-day fundraising cycling ride (MADRIDE) over a distance of 3515 km. Twenty-four hour...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Wundersitz D,Williamson J,Nadurata V,Nolan K,Lavie C,Kingsley M

    更新日期:2019-07-01 00:00:00

  • Global longitudinal speckle-tracking strain is predictive of left ventricular remodeling after coronary angioplasty in patients with recent non-ST elevation myocardial infarction.

    abstract:AIMS:To test whether two-dimensional longitudinal strain (2DSE) performed after revascularization by percutaneous coronary intervention (PCI) could predict left ventricular (LV) remodeling in patients with recent non-ST elevation myocardial infarction (NSTEMI). METHODS:In 70 patients (62.7 ± 8.7 years) with recent NST...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: D'Andrea A,Cocchia R,Caso P,Riegler L,Scarafile R,Salerno G,Golia E,Di Salvo G,Calabrò P,Bigazzi MC,Liccardo B,Esposito N,Cuomo S,Bossone E,Russo MG,Calabrò R

    更新日期:2011-12-01 00:00:00

  • Gender differences among Norwegian patients with heart failure.

    abstract:BACKGROUND:Recent studies have suggested differences in outcome and treatment between men and women with heart failure. The aim of this study was to see if there were gender differences in the treatment and outcome in real life heart failure patients. METHODS:Norwegian Heart Failure Registry was used. Three-thousand-s...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Brandsaeter B,Atar D,Agewall S,Norwegian Heart failure Registry.

    更新日期:2011-02-03 00:00:00

  • Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease.

    abstract:BACKGROUND:The objective of this prospective study was to assess the efficacy of exercise training as add-on to medical therapy in patients with congenital heart disease associated pulmonary arterial hypertension (CHD-APAH). METHODS:Patients with invasively confirmed CHD-APAH received in-hospital exercise training for...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Becker-Grünig T,Klose H,Ehlken N,Lichtblau M,Nagel C,Fischer C,Gorenflo M,Tiede H,Schranz D,Hager A,Kaemmerer H,Miera O,Ulrich S,Speich R,Uiker S,Grünig E

    更新日期:2013-09-20 00:00:00

  • Molecular mechanisms underlying HLA-DR-associated susceptibility to autoimmunity.

    abstract::We analyzed structural motifs of peptides bound to HLA-DR4 (DRB1*0405 and DRB1*0406) and DR9 (DRB1*0901) and found that: (a) AxxBxC motif where A, B, and C are hydrophobic, hydrophobic, and neutral, respectively, is important for binding to DR4; (b) Gln (Q) or Ser at position C allow high-affinity binding specific to ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Matsushita S,Fujisao S,Nishimura Y

    更新日期:1996-08-01 00:00:00

  • Racial disparities among Asian Americans with atrial fibrillation: An analysis from the NCDR® PINNACLE Registry.

    abstract:BACKGROUND:There is paucity of data on Atrial Fibrillation (AF) management and associated clinical outcomes among Asian Americans. This study sought to investigate baseline risk factor profiles, racial disparities in clinical management and adverse clinical outcomes among White and Asian Americans. METHODS:We used Nat...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Gu K,Mahtta D,Kaneria A,Sharedalal P,Dennis B,Song Y,Wei X,Khalid U,Hess P,Cho SH,Virani SS

    更新日期:2021-01-05 00:00:00

  • Feasibility of single-beat full-volume capture real-time three-dimensional echocardiography for quantification of right ventricular volume: validation by cardiac magnetic resonance imaging.

    abstract:BACKGROUND:The lack of an accurate noninvasive method for assessing right ventricular (RV) volume and function has been a major deficiency of two-dimensional (2D) echocardiography. The aim of our study was to test the feasibility of single-beat full-volume capture with real-time three-dimensional echo (3DE) imaging sys...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Zhang QB,Sun JP,Gao RF,Lee AP,Feng YL,Liu XR,Sheng W,Liu F,Yang XS,Fang F,Yu CM

    更新日期:2013-10-09 00:00:00

  • Exercise training program characteristics and magnitude of change in functional capacity of heart failure patients.

    abstract:BACKGROUND:Intuitively higher exercise program volume may be the primary stimulus for physical adaptation. We sought to establish if aerobic exercise training program characteristics produced different effect sizes for change in cardiorespiratory fitness in heart failure patients. METHODS:We conducted a MEDLINE search...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析


    authors: Ismail H,McFarlane JR,Dieberg G,Smart NA

    更新日期:2014-01-15 00:00:00

  • Amine-enriched surface modification facilitates expansion, attachment, and maintenance of human cardiac-derived c-kit positive progenitor cells.

    abstract:BACKGROUND:Stem cells have a low expansion rate and are difficult to maintain in vitro. To overcome the problems of cardiovascular regeneration, we developed a novel method of stem cell cultivation in culture vessels with amine and carboxyl coatings. METHODS AND RESULTS:We isolated cardiac stem/progenitor cells from i...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Choi SH,Jung SY,Yoo SM,Asahara T,Suh W,Kwon SM,Baek SH

    更新日期:2013-09-20 00:00:00

  • Influence of sub valvular pathology on immediate results and follow up events of Inoue balloon mitral valvotomy.

    abstract::We evaluated the influence of sub valvular pathology (SVP) on the immediate results and follow up events of Inoue Balloon Mitral Valvotomy (IBMY) in 206 patients with severe SVP (Group I) and compared their outcome with 206 age and sex matched patients selected from the rest of 619 patients having mild/moderate SVP (G...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Sreenivas Kumar A,Kapoor A,Sinha N,Goel PK,Umeshan CV,Tiwari S,Shahi M

    更新日期:1998-12-31 00:00:00

  • The effect of atorvastatin on heart rate variability and lipoproteins in patients treated with coronary bypass surgery.

    abstract::Statins reduce mortality in patients with coronary heart disease (CHD). An antiarrhythmic effect of statins has been suggested and reported as a possible contributing mechanism. The aim of this study was to examine whether atorvastatin had any effect on heart rate variability (HRV), an important predictor of sudden ca...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Riahi S,Schmidt EB,Amanavicius N,Karmisholt J,Jensen HS,Christoffersen RP,Niebuhr U,Christensen JH,Toft E

    更新日期:2006-08-28 00:00:00

  • Growth-differentiation factor 15 for long-term prognostication in patients with non-ST-elevation acute coronary syndrome: an Invasive versus Conservative Treatment in Unstable coronary Syndromes (ICTUS) substudy.

    abstract:BACKGROUND:No five-year long-term follow-up data is available regarding the prognostic value of GDF-15. Our aim is to evaluate the long-term prognostic value of admission growth-differentiation factor 15 (GDF-15) regarding death or myocardial infarction (MI) in patients with non-ST-elevation acute coronary syndrome (NS...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Damman P,Kempf T,Windhausen F,van Straalen JP,Guba-Quint A,Fischer J,Tijssen JG,Wollert KC,de Winter RJ,Hirsch A,ICTUS investigators.

    更新日期:2014-03-15 00:00:00

  • Effect of free fatty acid inhibition on silent and symptomatic myocardial ischemia in diabetic patients with coronary artery disease.

    abstract:OBJECTIVE:Free fatty acid inhibition with trimetazidine (TMZ) improves myocardial metabolism and myocardial ischemia in patients with coronary artery disease (CAD). Because of its effect on myocardial glucose utilization TMZ may represent a therapeutic option in diabetic patients with CAD. Aim of the present study was ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Marazzi G,Wajngarten M,Vitale C,Patrizi R,Pelliccia F,Gebara O,Pierri H,Ramires JA,Volterrani M,Fini M,Rosano GM

    更新日期:2007-08-09 00:00:00

  • Prognostic impact of subclinical thyroid dysfunction in heart failure.

    abstract:BACKGROUND:Therapeutic and prognostic implications of subclinical thyroid dysfunction in patients with heart failure (HF) are unclear. We compared the prognostic impact of euthyroidism, subclinical thyroid dysfunction, and euthyroid sick syndrome (ESS) in systolic HF. METHODS:We included 1032 patients hospitalized for...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Frey A,Kroiss M,Berliner D,Seifert M,Allolio B,Güder G,Ertl G,Angermann CE,Störk S,Fassnacht M

    更新日期:2013-09-20 00:00:00

  • Macroscopic assessment of porcine coronary vessel wall trauma after percutaneous cardiac catheterization and intervention.

    abstract::A macroscopic pathological assessment of the coronary arteries of a pig's heart, in which stent implantation and intra-vascular ultrasound and thermography pullbacks were performed, shows that during percutaneous coronary catheterization and intervention, one of the major vessel traumas occurs in the very proximal par...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Agostoni P,Borenstein N,Verheye S,Van Langenhove G

    更新日期:2006-11-18 00:00:00

  • Electrocardiographic diagnosis of right ventricular infarction in the presence of left ventricular posterior infarction.

    abstract::Conventional criteria of ST segment elevation in right sided chest leads or loss of initial 'r' wave in leads V3R or V4R have low sensitivity and specificity in diagnosing right ventricular involvement in the presence of left ventricular posterior infarction. Slurring of R wave either in right sided chest leads or in ...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Mittal SR,Jain S

    更新日期:1999-01-01 00:00:00

  • A 20-year perspective of in hospital cardiac arrest: Experiences from a university hospital with focus on wards with and without monitoring facilities.

    abstract:BACKGROUND:Knowledge about change in the characteristics and outcome of in hospital cardiac arrests (IHCAs) is insufficient. AIM:To describe a 20year perspective of in hospital cardiac arrest (IHCA) in wards with and without monitoring capabilities. SETTINGS:Sahlgrenska University Hospital (800 beds). The number of b...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Adielsson A,Karlsson T,Aune S,Lundin S,Hirlekar G,Herlitz J,Ravn-Fischer A

    更新日期:2016-08-01 00:00:00

  • A guide for identification and continuing care of adult congenital heart disease patients in primary care.

    abstract:BACKGROUND:Surgical and other advances in the treatment and care of congenital heart disease have resulted in a significant increase in the number of adults with congenital heart disease (ACHD), many of whom have no regular cardiology follow-up. Optimised care for ACHD patients requires continuity of specialist and sha...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ellison S,Lamb J,Haines A,O'Dell S,Thomas G,Sethi S,Ratcliffe J,Chisholm S,Vaughan J,Mahadevan VS

    更新日期:2013-03-10 00:00:00

  • Isolated congenital left ventricular diverticulum in an elderly patient that was identified because of an incidental finding during a complete medical checkup.

    abstract::Congenital left ventricular diverticulum is a rare cardiac malformation in an elderly patient. It frequently is associated with other cardiac or non-cardiac congenital malformations. We present an asymptomatic elderly patient, evaluated because of an incidental finding of a left ventricular anatomic change on chest co...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Sakabe K,Fukuda N,Fukuda Y,Wakayama K,Nada T,Morishita S,Shinohara H,Tamura Y

    更新日期:2008-04-10 00:00:00

  • Extent of lung involvement over severity of cardiac disease for the prediction of adverse outcome in COVID-19 patients with cardiovascular disease.

    abstract:BACKGROUND:Aim of the present study was to assess if the presence of high cardiovascular risk, left ventricle systolic dysfunction or elevated BNP or Troponin are able to independently predict the outcome of patients with known cardiac disease and COVID-19 pneumonia. METHODS AND RESULTS:From March 7th to April 28th, f...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Andreini D,Conte E,Mushtaq S,Gigante C,Mancini ME,Annoni A,Stefanini G,Agalbato C,Cosentino N,Pontone G,Assanelli E,Pepi M

    更新日期:2021-01-15 00:00:00

  • Skeletal muscle fibres synthesis in heart failure: role of PGC-1alpha, calcineurin and GH.

    abstract:BACKGROUND:Patients with congestive heart failure (CHF) have decreased exercise capacity because of muscle fatigability. Symptoms are due to a specific myopathy with increased expression of fast type II fibres, fast MHCs and muscle atrophy. PGC-1alpha, a potent transcriptional coactivator for nuclear receptors, induces...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Vescovo G,Ravara B,Gobbo V,Angelini A,Dalla Libera L

    更新日期:2005-10-10 00:00:00

  • Hypertension control in a large multi-ethnic cohort in Amsterdam, The Netherlands: the HELIUS study.

    abstract:OBJECTIVE:Hypertension is a major problem among European ethnic minority groups. We assessed the current situation of hypertension prevalence and its management among a multi-ethnic population in Amsterdam, The Netherlands. METHODS:Data from the HELIUS study were used including 12,974 participants (1871 Ghanaian, 2184...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Agyemang C,Kieft S,Snijder MB,Beune EJ,van den Born BJ,Brewster LM,Ujcic-Voortman JJ,Bindraban N,van Montfrans G,Peters RJ,Stronks K

    更新日期:2015-03-15 00:00:00

  • Pathophysiology of acute coronary syndromes in the elderly.

    abstract::Elderly patients represent an important proportion of the acute coronary syndrome (ACS) population. Furthermore, this group of ACS patients is continuously growing because of the progressive ageing of the population. The ageing process implies marked changes in patient physiology that directly impact in their risk. Ho...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Badimon L,Bugiardini R,Cubedo J

    更新日期:2016-11-01 00:00:00

  • Dilated cardiomyopathy and myocarditis in Kenya: an endomyocardial biopsy study.

    abstract::We have studied, by light and electron microscopy, left ventricular endomyocardial biopsy specimens from 18 African patients (14 men) with idiopathic dilated cardiomyopathy in Nairobi. Nine patients (50%) had evidence of healing myocarditis, that is the presence of a mild inflammatory cell infiltration within the myoc...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Sanderson JE,Olsen EG,Gatei D

    更新日期:1993-09-01 00:00:00

  • Overriding atrioventricular valves. An angiographic-anatomical correlate.

    abstract::An analysis of 6 patients with overriding atrioventricular valve was performed in order to correlate the anatomic and angiographic features of this malformation. The atrial arrangement was usual (situs solitus) in each patient. The ventricular chambers were normally related in 4 and the mirror image of normal in 2. Th...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Soto B,Ceballos R,Nath PH,Bini RM,Pacifico AD,Bargeron LM Jr

    更新日期:1985-11-01 00:00:00

  • Right ventricular sugars and fats in chronic thromboembolic pulmonary hypertension.

    abstract:BACKGROUND/OBJECTIVES:Several studies have already shown the correlation between the right ventricle (RV) hemodynamic values and either glucose uptake or fatty acid uptake in the RV, respectively. However, there are few studies to compare the RV metabolic alteration before and after treatment for pulmonary hypertension...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Sakao S,Daimon M,Voelkel NF,Miyauchi H,Jujo T,Sugiura T,Ishida K,Tanabe N,Kobayashi Y,Tatsumi K

    更新日期:2016-09-15 00:00:00

  • Impact of infarct location and size on clinical outcome after ST-elevation myocardial infarction treated by primary percutaneous coronary intervention.

    abstract:BACKGROUND:For patients suffering from acute ST-elevation myocardial infarction (STEMI), it is controversial whether infarct location predicts worse clinical outcome independently of infarct size. We therefore aimed to investigate the prognostic relevance of infarct location in relation to infarct size in STEMI patient...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Reindl M,Holzknecht M,Tiller C,Lechner I,Schiestl M,Simma F,Pamminger M,Henninger B,Mayr A,Klug G,Bauer A,Metzler B,Reinstadler SJ

    更新日期:2020-02-15 00:00:00

  • Cost analysis of radiofrequency catheter ablation for atrial fibrillation.

    abstract::Atrial fibrillation is the most common arrhythmia associated with increased mortality and morbidity. Its management requires high healthcare expenditures; 52%-70% of expenses for AF care are constituted by hospitalization costs. The current management strategies of pharmacological rhythm control and pharmacological or...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Gorenek B,Kudaiberdieva G

    更新日期:2013-09-10 00:00:00

  • A multicenter study of the association of serum uric acid, serum creatinine, and diuretic use in hypertensive patients.

    abstract:BACKGROUND:Individuals with hypertension and hyperuricemia have an increased risk of coronary artery disease and cerebral vascular disease as compared to patients with normal uric acid levels. Our aim is to determine the prevalence of hyperuricemia in hypertensive patients in Taiwan, and whether serum uric acid (SUA) i...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Lin CS,Hung YJ,Chen GY,Tzeng TF,Lee DY,Chen CY,Huang WP,Huang CH

    更新日期:2011-05-05 00:00:00

  • Paleopathology of cardiovascular diseases in South American mummies.

    abstract:BACKGROUND:Cardiovascular disease has emerged as the world's leading cause of death in the last century. An epidemiological focus of this disease that extends not only beyond the developed world but also far back into antiquity asks new questions about associated risk factors. Ancient mummies found in the Atacama deser...

    journal_title:International journal of cardiology

    pub_type: 历史文章,杂志文章


    authors: Gabrovsky AN,O'Neill KD,Gerszten E

    更新日期:2016-11-15 00:00:00