Abstract:
BACKGROUNDS:Although the rescue of cellular senescence during ex vivo expansion of human-derived cardiac progenitor cells (hCPC) is critical for the application of autologous stem cell therapy in cardiovascular disease, the underlying molecular pathways during replicative senescence in hCPC have not been fully defined. Thus, we examined whether the regulation of mitogen-activated protein kinases activation could facilitate the recovery of human c-kit-positive hCPCs (hCPC(c-kit+)) and whether senescence is reactive oxygen species (ROS)-dependent or -independent. METHODS AND RESULTS:To investigate the molecular pathways of replicative cellular senescence, we first evaluated cellular senescence in ex vivo-expanded hCPC(c-kit+) by using senescence-associated β-galactosidase (SA-β-gal) activity with enlarged cytoplasm and observed increased expression of cell senescence-related pivotal molecules, including TP53, cleavage Mdm2 (cMdm2), and Mdm2. Unexpectedly, we found that the extracellular signal-regulated kinase (ERK) was markedly activated in aged hCPC(c-kit+), with reduced proliferative activity. SA-β-gal activity and cytoplasm size in senescent hCPC(c-kit+) were significantly reduced, with reduced TP53 and cMdm2 expression after treatment with a specific ERK inhibitor (U0126). We examined whether the signaling in ERK inhibitory rescue of hCPC(c-kit+) senescence is ROS-dependent. Interestingly, the increased ROS level was not changed after treatment with a specific ERK inhibitor. Similarly, the increased expression levels of endogenous antioxidant enzymes, e.g., peroxiredoxin (Prdx)-1 and 2, in senescent hCPC(c-kit+) were not changed after treatment with a specific ERK inhibitor. CONCLUSIONS:From the above results, we conclude that the specific inhibition of ERK during cellular senescence might rescue bioactivities of senescent hCPC(c-kit+) in a ROS-independent manner.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Choi SH,Jung SY,Yoo SY,Yoo SM,Kim DY,Kang S,Baek SH,Kwon SMdoi
10.1016/j.ijcard.2013.08.076subject
Has Abstractpub_date
2013-10-25 00:00:00pages
73-82issue
1eissn
0167-5273issn
1874-1754pii
S0167-5273(13)01659-8journal_volume
169pub_type
杂志文章abstract::We studied hypertrophic patterns in the electrocardiograms of 60 Nigerian hypertensives. Thirty were in heart failure and 30 without failure (matched for age and sex). Combined left ventricular and left atrial hypertrophy was the commonest finding occurring in 58.3%, followed by left ventricular hypertrophy alone in 3...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(91)90129-d
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Although several hypotheses have been proposed, the true origin and pathogenesis of aortic intramural hematoma (IMH) remain unclear. Evolution of patients with aortic IMH is highly variable. Progression to classic aortic dissection, aneurysm or to complete resolution have been described. Our purpose was to a...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.09.170
更新日期:2017-12-15 00:00:00
abstract:OBJECTIVE:The effects of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) on dementia risk in patients with type 2 diabetes mellitus (DM) and hypertension remain unknown. We investigated the effects of ACEIs and ARBs on dementia risk in patients with type 2 DM and hypertension....
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.06.215
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Pulmonary endothelial damage has a negative impact on the maintenance of normal pulmonary vascular function. Such damage results in delayed thrombus dissolution and vascular remodeling in chronic thromboembolic pulmonary hypertension (CTEPH). Although endothelial progenitor cells (EPCs) may be incorporated i...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.07.017
更新日期:2020-01-15 00:00:00
abstract::With the advent of transesophageal echocardiography (TEE), thrombi of the aorta are becoming increasingly recognized as possible sources of systemic emboli. This report describes a 58-year-old woman with multiple unexplained peripheral emboli. A giant thrombus of the descending aorta has been identified as the source ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/s0167-5273(02)00509-0
更新日期:2003-06-01 00:00:00
abstract::The diameters of the orifices of the pulmonary trunk and aorta were measured from cineangiocardiographic films in 35 children (mean age 7 years and 6 months, mean height 124.3 cm) without heart disease. Measurements were obtained in the lateral projection in early systole. Calipers and a micrometer were used and the v...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(87)90202-6
更新日期:1987-03-01 00:00:00
abstract::During acute myocardial infarction and in the reperfused heart, loss of cardiomyocytes is mostly caused by apoptosis and necrosis. As apoptosis was considered as the only form of regulated cell death for many years, initial studies investigating cardiomyocyte cell death mainly focused on direct inhibition of apoptosis...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2012.03.055
更新日期:2013-05-25 00:00:00
abstract::Takotsubo cardiomyopathy is a recently recognised acute cardiac entity. It involves transient left ventricular apical ballooning, which is usually preceded by an episode of physiological or emotional stress. Its presentation may mimic acute myocardial infarction but there is no evidence of obstructive disease at coron...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.08.062
更新日期:2009-02-20 00:00:00
abstract:BACKGROUND:Untreated and preclinical heart failure patients with reduced ejection fraction (HFrEF) have an impaired ability to alleviate excess intravascular volume. OBJECTIVES:To investigate 1) the renal response to intravascular volume expansion in euvolemic and optimally treated HFrEF patients and 2) loop diuretic ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.05.041
更新日期:2017-09-15 00:00:00
abstract::Increased native myocardial T1 times in chronic kidney disease (CKD) may be due to diffuse interstitial myocardial fibrosis (DIF) or due to interstitial edema/inflammation. Concerns relating to nephrogenic systemic fibrosis with gadolinium-based contrast agents (GBCA) limit their use in end-stage kidney disease (ESKD)...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.06.007
更新日期:2019-10-15 00:00:00
abstract::Spontaneous coronary artery dissection (SCAD) causing acute myocardial infarction is a rare event. It occurs mostly in young women without traditional risk factors for coronary artery disease, particularly during the peripartum period. We describe two occurrences of SCAD in young women in whom coronary atherosclerosis...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2005.12.021
更新日期:2007-01-31 00:00:00
abstract::To determine the benefit of atrial contribution on work capacity in relation to left ventricular ejection fraction, we studied 17 patients (68 +/- 13 years) with dual chamber pacemakers (DDD) implanted for high degree atrioventricular (AV) block. In random order they were assigned to rate responsive ventricular (VVIR)...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(95)02308-j
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Lp(a), implicated in both atherogenesis and thrombosis pathways, varies significantly by demographic and metabolic factors, providing challenges for its use in Coronary Heart Disease (CHD) risk. The purpose of this study was to investigate whether type-2 diabetic subjects, relative to non-diabetics, might be...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.02.021
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Several intervention studies have investigated the relation between potassium intake and blood-pressure, particularly in hypertensive subjects. However, uncertainties still exist about the existence and the amount of such an effect, and about the role of some potential effect-modifiers, including the baselin...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ijcard.2016.12.048
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:AV delay optimisation of biventricular pacing devices (cardiac resynchronisation therapy, CRT) is performed in trials and recommended by current guidelines. The Doppler echocardiographic iterative method is the most commonly recommended. Yet whether it can be executed reliably has never been tested formally....
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.09.097
更新日期:2013-09-20 00:00:00
abstract:INTRODUCTION:Coronary artery ectasia (CAE) is defined as localized or diffuse dilatation of the epicardial coronary arteries. We sought to determine whether isolated CAE may alter P-wave duration and dispersion (PD). METHODS:The study population consisted of 26 patients (mean age: 61.6+/-11.0 years) with isolated CAE ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.01.042
更新日期:2008-04-25 00:00:00
abstract::Desynchronization induced by right ventricular pacing may increase the risk for heart failure. We aimed to compare left ventricular (LV) function, synchrony and left atrial size along with NT-proBNP levels, in 2 different modes of pacing: AAIR versus DDDR. This was a prospective study of 60 patients with sick sinus sy...
journal_title:International journal of cardiology
pub_type: 信件,随机对照试验
doi:10.1016/j.ijcard.2009.03.017
更新日期:2010-10-08 00:00:00
abstract:BACKGROUND:Patients with systemic right ventricle (sRV), including transposition of great arteries (TGA) after atrial switch procedure and congenitally corrected transposition of great arteries (ccTGA), may require anticoagulation for thromboembolism (TE) prevention. In the absence of data on non-vitamin K antagonist o...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.08.034
更新日期:2021-01-01 00:00:00
abstract::We report a case of right ventricular perforation by a passive-tined permanent pacemaker lead detected 1 month after implantation. The pacemaker lead was seen to perforate through the myocardium and pericardium and moving freely in the mediastinum with no evidence of pericardial effusion. Extraction was uneventful. ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.05.064
更新日期:2007-01-31 00:00:00
abstract::A 25-year-old man with massive pericardial effusion is presented. The high lymphocyte amount and cytological analysis of the aspirated fluid suggested tuberculous or malignant pericarditis. The chylous nature of the effusion was only recognized after hemipericardiectomy, when reaccumulation of fluid into the pleural s...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(87)90186-0
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:The prospective EUROVISION Registry was designed to capture patterns of use and short term outcomes in consecutive patients undergoing PCI with bivalirudin (BIV) in European centres. METHODS:A total of 2018 consecutive BIV-treated patients were included from 58 sites in 5 countries (Germany, Italy, France, Aus...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.03.003
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Dofetilide is a class III antiarrhythmic drug that has been reported to be safe and efficacious in the treatment of atrial dysrhythmias with a known initial risk of QT prolongation and torsades de pointes (TdP). As a result, the Federal Drug Administration (FDA) mandated in-hospital dofetilide initiation and...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.01.157
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Kawasaki disease is an acute, self-limited vasculitis of unknown etiology. Coronary artery involvement is the predominant complication, ranging from no involvement to dilation through to aneurysm formation. We sought to determine trends over time and associated factors for normalized coronary artery dimensio...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.04.019
更新日期:2009-07-24 00:00:00
abstract:OBJECTIVE:Angiotensin-converting enzyme inhibitor (ACEI) is beneficial in patients with congestive heart failure (CHF). Some, but not all, angiotensin receptor blocker (ARB) was demonstrated to be effective as "add-on" therapy. We investigated whether irbesartan is useful as an add-on therapy in CHF. DESIGN:Randomized...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ijcard.2007.02.016
更新日期:2008-03-28 00:00:00
abstract:BACKGROUND:Abnormal prolongation of QRS duration is a common finding in patients with chronic heart failure, and is associated with an impaired prognosis. The optimum QRS duration for separating chronic heart failure patients with respect to prognosis has not been determined. Whilst resynchronisation of ventricular con...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(02)00270-x
更新日期:2002-12-01 00:00:00
abstract:INTRODUCTION:In general, early experience with the first-generation cryoballoon introduced an increase in radiation exposure as compared to traditional radiofrequency ablations for atrial fibrillation (AF). However, through operator vigilance and the incorporation of various techniques and technologies, procedural radi...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.06.018
更新日期:2020-01-15 00:00:00
abstract:BACKGROUND:Current clinical guidelines recommend that risk stratification for ischaemic stroke in patients with nonvalvular AF (NVAF) should be performed using the CHA2DS2-VASc score (Congestive heart failure, Hypertension, Age≥ 75years [double], Diabetes mellitus, previous thromboembolism [double], Vascular disease, A...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.11.196
更新日期:2015-02-15 00:00:00
abstract:BACKGROUND:Heart failure (HF) imposes both direct costs to healthcare systems and indirect costs to society through morbidity, unpaid care costs, premature mortality and lost productivity. The global economic burden of HF is not known. METHODS:We estimated the overall cost of heart failure in 2012, in both direct and ...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2013.12.028
更新日期:2014-02-15 00:00:00
abstract::We analyzed the ventricular expression of atrial and brain natriuretic peptides (ANP and BNP) in patients with myocarditis. Immunohistochemical analysis of endomyocardial biopsy specimens showed ANP and BNP immunoreactivity in the early myocarditis group (ANP in 4/10 and BNP in 3/10) and the late myocarditis group (AN...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(95)02468-9
更新日期:1995-12-01 00:00:00
abstract::Carlos Chagas, the discoverer of Chagas' disease was nominated to the Nobel Prize in 1921, but none did win the prize in that year. As a leader of a young scientist team, he discovered all aspects of the new disease from 1909 to 1920. It is still obscure why he did not win the Nobel Prize in 1921. Chagas was discarded...
journal_title:International journal of cardiology
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.ijcard.2013.08.137
更新日期:2013-11-20 00:00:00