Practice variation in the re-initiation of dofetilide: An observational study.


BACKGROUND:Dofetilide is a class III antiarrhythmic drug that has been reported to be safe and efficacious in the treatment of atrial dysrhythmias with a known initial risk of QT prolongation and torsades de pointes (TdP). As a result, the Federal Drug Administration (FDA) mandated in-hospital dofetilide initiation and adherence to a common dosing protocol. However, there is a lack of clarity on how to manage dofetilide re-initiation. METHODS:An observational survey was performed including 347 cardiologists in the United States and worldwide to evaluate the deviations from approved manufacturer's protocol during dofetilide initiation and re-initiation among practicing cardiologists. RESULTS:Most practicing cardiologists were cautious about outpatient dofetilide use and adhered to the manufacturer's in-patient dofetilide protocol during de-novo initiation and reported low incidence of TdP in clinical practice. There were substantial differences among practicing cardiologists with deviation from the manufacturer's protocol during re-initiation of dofetilide. About 21% cardiologists always admitted patients to the hospital while 37% admitted patients <10% of the time for dofetilide re-initiation. Only 4% reported major adverse events with outpatient dofetilide re-initiation. There was also wide variation regarding monitoring of electrolytes and QT interval as an outpatient with dofetilide. CONCLUSION:There is significant practice pattern variation in the use of dofetilide for the management of AF. This degree of variation noted is concerning and is a reflection of the current lack of substantial clinical evidence in the re-initiation dofetilide protocol to help direct the provider.


Int J Cardiol


Turagam MK,Afzal MR,Reddy M,Pillarisetti J,Lavu M,Atkins D,Jeffrey C,Christensen K,Pimentel R,Dendi R,Vacek J,Hurwitz J,Di Biase L,Natale A,Lakkireddy D




Has Abstract


2017-06-01 00:00:00












  • Incidence of atrial fibrillation in relation to birth weight and preterm birth.

    abstract:BACKGROUND:Hypertension, type 2 diabetes and other cardiovascular diseases, all risk factors for atrial fibrillation, are associated with birth weight. It remains unclear, however, whether risk of atrial fibrillation is also associated with birth weight. We investigated the associations of birth weight and preterm birt...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Larsson SC,Drca N,Jensen-Urstad M,Wolk A

    更新日期:2015-01-15 00:00:00

  • Electrocardiographic hypertrophic patterns in hypertensive Nigerians.

    abstract::We studied hypertrophic patterns in the electrocardiograms of 60 Nigerian hypertensives. Thirty were in heart failure and 30 without failure (matched for age and sex). Combined left ventricular and left atrial hypertrophy was the commonest finding occurring in 58.3%, followed by left ventricular hypertrophy alone in 3...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Olubodun JO,Cole TO,Falase AO,Olatunde S,Lawal A

    更新日期:1991-01-01 00:00:00

  • Cannabis as a precipitant of cardiovascular emergencies.

    abstract::Cannabis smoking is on the increase both in the United Kingdom and in the United States. For over three decades it has been known that cannabis has pathophysiological effects on the cardiovascular system, and previously an association with an increased risk of myocardial infarction has been reported. However, it is no...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Lindsay AC,Foale RA,Warren O,Henry JA

    更新日期:2005-09-30 00:00:00

  • A multicenter study of the association of serum uric acid, serum creatinine, and diuretic use in hypertensive patients.

    abstract:BACKGROUND:Individuals with hypertension and hyperuricemia have an increased risk of coronary artery disease and cerebral vascular disease as compared to patients with normal uric acid levels. Our aim is to determine the prevalence of hyperuricemia in hypertensive patients in Taiwan, and whether serum uric acid (SUA) i...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Lin CS,Hung YJ,Chen GY,Tzeng TF,Lee DY,Chen CY,Huang WP,Huang CH

    更新日期:2011-05-05 00:00:00

  • Cinaciguat prevents neointima formation after arterial injury by decreasing vascular smooth muscle cell migration and proliferation.

    abstract:AIMS:Vascular smooth muscle cell (VSMC) migration, proliferation and remodeling of the extracellular matrix contribute to lumen loss after arterial injury leading to restenosis. Several studies indicated the role of the cyclic guanosine monophosphate signaling in neointimal formation. Cinaciguat, the novel soluble guan...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Hirschberg K,Tarcea V,Páli S,Barnucz E,Gwanmesia PN,Korkmaz S,Radovits T,Loganathan S,Merkely B,Karck M,Szabó G

    更新日期:2013-07-31 00:00:00

  • Comparison of angiotensin-converting enzyme inhibitor alone and in combination with irbesartan for the treatment of heart failure.

    abstract:OBJECTIVE:Angiotensin-converting enzyme inhibitor (ACEI) is beneficial in patients with congestive heart failure (CHF). Some, but not all, angiotensin receptor blocker (ARB) was demonstrated to be effective as "add-on" therapy. We investigated whether irbesartan is useful as an add-on therapy in CHF. DESIGN:Randomized...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kum LC,Yip GW,Lee PW,Lam YY,Wu EB,Chan AK,Fung JW,Chan JY,Zhang Q,Kong SL,Yu CM

    更新日期:2008-03-28 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Schneider C,Malisius R,Küchler R,Lampe F,Krause K,Bahlmann E,Kuck KH

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Hsu YJ,Hsu SC,Chang YL,Huang SM,Shih CC,Tsai CS,Lin CY

    更新日期:2018-02-01 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Mishra MB,Cooke RA,Jackson G,Chambers JB

    更新日期:1997-01-03 00:00:00

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    abstract:BACKGROUND:It is not clarified whether the transient, regional left ventricular dysfunction (TRLVD) associated with several neurological disorders shares the same pathophysiology with the classical tako-tsubo cardiomyopathy occurring without overt neurological disease, and whether it is appropriate to include these pat...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Porto I,Della Bona R,Leo A,Proietti R,Pieroni M,Caltagirone C,Spalletta G,Bolognese L,Cravello L

    更新日期:2013-09-10 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Seely S

    更新日期:1988-08-01 00:00:00

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    abstract::Latest advances in the diagnostic management of arrhythmogenic right ventricular dysplasia-cardiomyopathy (ARVD/C) confirm that ARVD/C is not a rare disease (one affected in 1000-1250 inhabitants) and is of familial origin in 50-80% of cases. Diagnostic criteria defined in 1994 lead to low rates in the diagnosis of AR...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Peters S

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    journal_title:International journal of cardiology

    pub_type: 信件


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    更新日期:2007-04-12 00:00:00

  • Responses of vascular smooth muscle cells to estrogen are dependent on balance between ERK and p38 MAPK pathway activities.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Robida A

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  • Prognostic value of non-high-density lipoprotein cholesterol for mortality in patients with coronary heart disease: A systematic review and meta-analysis.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章,meta分析,评审


    authors: Liao P,Zeng R,Zhao X,Guo L,Zhang M

    更新日期:2017-01-15 00:00:00

  • Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Tousoulis D,Antoniades C,Bosinakou E,Kotsopoulou M,Tsoufis C,Marinou K,Charakida M,Stefanadi E,Vavuranakis M,Latsios G,Stefanadis C

    更新日期:2007-02-07 00:00:00

  • The role of angioplasty in patients with acute coronary syndrome and previous coronary artery bypass grafting.

    abstract:INTRODUCTION:Angioplasty has changed the management of acute coronary syndrome (ACS). However, in patients with previous coronary artery bypass grafting (CABG), the role of angioplasty in the management of ACS is widely debated. Lack of clear guidelines leads to subjective and often stereotypical assessments based on c...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Potluri R,Baig M,Mavi JS,Ali N,Aziz A,Uppal H,Chandran S

    更新日期:2014-10-20 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Salloum JA,Thomas D,Evans J

    更新日期:1991-07-01 00:00:00

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    abstract:BACKGROUND:High-density lipoprotein cholesterol (HDL-C) is a strong inverse predictor of cardiovascular events. The aim of the current study was to evaluate the correlation between changes in HDL-C and subsequent cardiovascular events. METHODS:Study population comprised 13,037 subjects free of cardiovascular disease w...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Milwidsky A,Kivity S,Kopel E,Klempfner R,Berkovitch A,Segev S,Sidi Y,Goldenberg I,Maor E

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    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


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    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


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    journal_title:International journal of cardiology

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    authors: Gao J,Ren M,Liu Y,Gao M,Sun B

    更新日期:2016-11-01 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


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    更新日期:2016-11-01 00:00:00

  • Effect of preoperative evaluation by multidetector computed tomography in percutaneous coronary interventions of chronic total occlusions.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ueno K,Kawamura A,Onizuka T,Kawakami T,Nagatomo Y,Hayashida K,Yuasa S,Maekawa Y,Anzai T,Jinzaki M,Kuribayashi S,Ogawa S

    更新日期:2012-04-05 00:00:00

  • The role of cytokines in cardiac surgery.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


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    更新日期:1996-04-26 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Figueras J,Cortadellas J,Gil CP,Domingo E,Soler JS

    更新日期:2006-08-10 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Isorni MA,Moisson L,Moussa NB,Monnot S,Raimondi F,Roussin R,Boet A,van Aerschot I,Fournier E,Cohen S,Kara M,Hascoet S

    更新日期:2020-12-01 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Agudelo V,Millán X,Li CH,Asmarats L,Fernández-Peregrina E,Santaló M,Jimenez-Kockar M,Gheorghe L,Serra A,Arzamendi D

    更新日期:2020-11-15 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ohmoto Y,Ikari Y,Hara K

    更新日期:1996-08-01 00:00:00