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Altered erythrocyte n-3 fatty acids in Mediterranean patients with coronary artery disease.

Abstract：

:A low frequency of ischaemic heart diseases in Eskimos has been related to polyunsaturated fatty acids. We therefore studied fatty acid patterns associated with coronary artery disease (CAD) for a possible relationship between fatty acid profile and CAD diagnosis in Mediterranean patients. The gas chromatography method was used to analyze the membranes of patients' erythrocytes. The patients without coronary stenosis were used as controls. Patients with CAD showed increased percentages of saturated fatty acids (35.8 vs. 34.2%, P<0.001) and monounsaturated fatty acids (14.6 vs. 13.6%, P<0.01), as well as reduced percentages of polyunsaturated fatty acids (38.5 vs. 41.3%, P<0.001). The decrease in polyunsaturated fatty acids percentages was due to the series of n-3 fatty acids (9.2 vs. 11.4%, P<0.001), mainly at the expense of docosahexaenoic acid [C22:6 (n-3)] (4.9+/-0.25% vs. 6.4+/-0.23%, P<0.001) and docosapentaenoic acid [C22:5 (n-3)] (3.0+/-0.19% vs. 3.9+/-0.12%, P<0.001). The study shows altered n-3 fatty acids in Mediterranean patients with CAD. Our data suggest that the percentage of docosahexaenoic and docosapentaenoic acids in erythrocytes could be used as indicators of an independent risk factor for coronary artery disease.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Paganelli F,Maixent JM,Duran MJ,Parhizgar R,Pieroni G,Sennoune S

doi

10.1016/s0167-5273(00)00442-3

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

27-32

issue

1

eissn

0167-5273

issn

1874-1754

pii

S0167527300004423

journal_volume

78

pub_type

杂志文章

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