当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling.

ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling.

Abstract：

RATIONALE:Pressure overload induces adaptive remodeling processes in the heart. However, when pressure overload persists, adaptive changes turn into maladaptive alterations leading to cardiac hypertrophy and heart failure. ATF3 is a stress inducible transcription factor that is transiently expressed following neuroendocrine stimulation. However, its role in chronic pressure overload dependent cardiac hypertrophy is currently unknown. OBJECTIVE:The objective of the study was to study the role of ATF3 in chronic pressure overload dependent cardiac remodeling processes. METHODS AND RESULTS:Pressure overload was induced by phenylephrine (PE) mini-osmotic pumps in various mice models of whole body, cardiac specific, bone marrow (BM) specific and macrophage specific ATF3 ablations. We show that ATF3-KO mice exhibit a significantly reduced expression of cardiac remodeling markers following chronic pressure overload. Consistently, the lack of ATF3 specifically in either cardiomyocytes or BM derived cells blunts the hypertrophic response to PE infusion. A unique cross-talk between cardiomyocytes and macrophages was identified. Cardiomyocytes induce an ATF3 dependent induction of an inflammatory response leading to macrophage recruitment to the heart. Adoptive transfer of wild type macrophages, but not ATF3-KO derived macrophages, into wild type mice potentiates maladaptive response to PE infusion. CONCLUSIONS:Collectively, this study places ATF3 as a key regulator in promoting pressure overload induced cardiac hypertrophy through a cross-talk between cardiomyocytes and macrophages. Inhibiting this cross-talk may serve as a useful approach to blunt maladaptive remodeling processes in the heart.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Koren L,Alishekevitz D,Elhanani O,Nevelsky A,Hai T,Kehat I,Shaked Y,Aronheim A

doi

10.1016/j.ijcard.2015.06.099

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

232-40

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(15)30037-1

journal_volume

198

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Disproportionate functional mitral regurgitation predicts a favourable response after MitraClip implant in patients with advanced heart failure. Real-world evidence of a new conceptual framework.

    abstract：INTRODUCTION:Accurate predictors of good clinical response after MitraClip implant in patients with heart failure (HF) are still lacking. Aim of this study was to investigate the role of regurgitant fraction >50% as a marker of disproportionate functional mitral regurgitation (FMR) in identifying best responders to Mit...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.08.026

    authors： Frea S,Pidello Md S,Boretto Md P,Rettegno Md S,Giordana Md F,Montefusco Md A,D'Amico M,La Torre MW,Rinaldi M,De Ferrari GM

    更新日期：2021-01-15 00:00:00

  • Effects of amlodipine and lacidipine on heart rate variability in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction.

    abstract：OBJECTIVE:To estimate the influence of therapy with amlodipine (A) or lacidipine (L) on heart rate variability (HRV) time and frequency domain parameters in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction. METHODS:After a 1-week washout period, the patients were ra...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2004.03.040

    authors： Zaliūnas R,Brazdzionyte J,Zabiela V,Jurkevicius R

    更新日期：2005-06-08 00:00:00

  • Atherosclerotic calcification and intimal medial thickness of the carotid arteries.

    abstract：BACKGROUND AND PURPOSE:Carotid intimal medial thickness (IMT) is a measure of subclinical atherosclerosis and is predictive of future cardiovascular events. The purpose of this study was to determine the significance and magnitude of association between IMT and atherosclerotic calcification of the carotid arteries. ME...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2004.12.039

    authors： Allison MA,Tiefenbrun J,Langer RD,Wright CM

    更新日期：2005-08-03 00:00:00

  • My patient wants to perform strenuous endurance exercise. What's the right advice?

    abstract：:Prolonged strenuous endurance exercise (SEE) such as marathon running has recently been associated with potential deleterious cardiac effects, particularly increased risk of atrial fibrillation (AF). This topic is medically important due to the increasing number of participants in SEE events lasting several hours, inc...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijcard.2015.06.014

    authors： Sanchis-Gomar F,Santos-Lozano A,Garatachea N,Pareja-Galeano H,Fiuza-Luces C,Joyner MJ,Lucia A

    更新日期：2015-10-15 00:00:00

  • Sudden cardiac arrest in a teenager as first manifestation of Takayasu's disease.

    abstract：:A 14-year-old girl was rescued from a sudden cardiac arrest at school. Aortography disclosed mild aortic root dilation with aortic valve incompetence and subocclusion of coronary ostia and left common carotid artery. An emergency aortocoronary bypass operation was undertaken, but the patient did not recover from cardi...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(94)90095-7

    authors： Basso C,Baracca E,Zonzin P,Thiene G

    更新日期：1994-01-01 00:00:00

  • Stroke in coronary artery bypass graft surgery: an analysis of the CASS experience. The participants in the Coronary Artery Surgery Study.

    abstract：:An analysis of the Coronary Artery Surgery Registry (CASS) was performed to determine the occurrence of stroke after coronary artery bypass surgery in patients entered into the Coronary Artery Surgery Study Registry. Of the 10,098 patients having coronary artery bypass surgery at the Coronary Artery Surgery Study part...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/0167-5273(92)90009-r

    authors： Frye RL,Kronmal R,Schaff HV,Myers WO,Gersh BJ

    更新日期：1992-08-01 00:00:00

  • The low expression of circulating microRNA-19a represents an additional mortality risk in stable patients with vascular disease.

    abstract：BACKGROUND:Secondary prevention of atherosclerotic vascular diseases represents a cascade of procedures to reduce the risk of future fatal and non-fatal cardiovascular events. We sought to determine whether the expression of selected microRNAs influenced mortality of stable chronic cardiovascular patients. METHODS:The...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijcard.2019.05.008

    authors： Mayer O Jr,Seidlerová J,Černá V,Kučerová A,Vaněk J,Karnosová P,Bruthans J,Wohlfahrt P,Cífková R,Pešta M,Filipovský J

    更新日期：2019-08-15 00:00:00

  • Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts.

    abstract：BACKGROUND:One of the most common nonsteroidal anti-inflammatory drugs (NSAIDs) used worldwide, diclofenac (DIC), has been linked to increased risk of cardiovascular disease (CVD). The molecular mechanism(s) by which DIC causes CVD is unknown. METHODS:Proteasome activities were studied in hearts, livers, and kidneys f...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.08.233

    authors： Ghosh R,Goswami SK,Feitoza LFBB,Hammock B,Gomes AV

    更新日期：2016-11-15 00:00:00

  • A novel haplotype in ABCA1 gene effects plasma HDL-C concentration.

    abstract：BACKGROUND AND OBJECTIVES:ATP-binding cassette transporter 1 (ABCA1) is a trans-membrane protein responsible for the efflux of cholesterol and phospholipids across the cell membrane, an essential step in the reverse cholesterol transport system. This study investigates the effect of five non-synonymous SNPs of ABCA1 ge...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2005.12.020

    authors： Saleheen D,Khanum S,Haider SR,Nazir A,Ahmad U,Khalid H,Hussain I,Shuja F,Shahid K,Habib A,Frossard PM

    更新日期：2007-01-31 00:00:00

  • Anorexia in chronic obstructive pulmonary disease--association to cachexia and hormonal derangement.

    abstract：BACKGROUND:In patients with chronic obstructive pulmonary disease (COPD) weight loss frequently occurs that may ultimately lead to cachexia as a serious co-morbidity, indicating severely impaired functional capacity, health status and increased mortality. Increased energy expenditure due to mechanic and metabolic ineff...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2006.07.088

    authors： Koehler F,Doehner W,Hoernig S,Witt C,Anker SD,John M

    更新日期：2007-06-25 00:00:00

  • Incidence and prognosis implications of long term left ventricular reverse remodeling in patients with dilated cardiomyopathy.

    abstract：BACKGROUND:Left ventricular reverse remodeling (LVRR) in dilated cardiomyopathy is poorly known within the context of current therapeutic approach. Our goal is to describe the present incidence of LVRR, the factors able to predict it and the long term prognosis of these patients. METHODS AND RESULTS:We performed a ret...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2015.11.099

    authors： Ruiz-Zamora I,Rodriguez-Capitan J,Guerrero-Molina A,Morcillo-Hidalgo L,Rodriguez-Bailon I,Gomez-Doblas JJ,de Teresa-Galvan E,Garcia-Pinilla JM

    更新日期：2016-01-15 00:00:00

  • Peri-procedural thrombocytopenia after aortic bioprosthesis implant: A systematic review and meta-analysis comparison among conventional, stentless, rapid-deployment, and transcatheter valves.

    abstract：BACKGROUND:Thrombocytopenia has been shown to occur soon after surgical biological aortic valve replacement (AVR), and recently reported also after transcatheter valve implantation (TAVI). The mechanism underlying this phenomenon is still unknown, and its clinical impact on the peri-operative outcome has been poorly in...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijcard.2019.07.056

    authors： Jiritano F,Santarpino G,Serraino GF,Ten Cate H,Matteucci M,Fina D,Mastroroberto P,Lorusso R

    更新日期：2019-12-01 00:00:00

  • Accuracy of methods for diagnosing atrial fibrillation using 12-lead ECG: A systematic review and meta-analysis.

    abstract：BACKGROUND:Screening for atrial fibrillation (AF) using 12-lead-electrocardiograms (ECGs) has been recommended; however, the best method for interpreting ECGs to diagnose AF is not known. We compared accuracy of methods for diagnosing AF from ECGs. METHODS:We searched MEDLINE, EMBASE, CINAHL and LILACS until March 24,...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijcard.2015.02.014

    authors： Taggar JS,Coleman T,Lewis S,Heneghan C,Jones M

    更新日期：2015-04-01 00:00:00

  • Isoproterenol enhancement of I(Ks) current in amiodarone-induced long QT syndrome.

    abstract：:The response over time of the QT interval and the Transmural Dispersion of Repolarization (TDR) to Isoproterenol infusion (ISO) in an 85 year-old-man with severe and syntomatic bradycardia, in the setting of an Amiodarone-induced Long QT Syndrome (LQTS) is the subject of this communication. ISO shortened the QT and de...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.07.175

    authors： Raviña T,Raviña M,Gutierrez J

    更新日期：2009-04-17 00:00:00

  • The effect of low-dose aspirin on colorectal cancer prevention and gastrointestinal bleeding according to bodyweight and body mass index: Analysis of UK primary care data.

    abstract：BACKGROUND:Meta-analysis of trial data suggests that in primary cardiovascular disease (CVD) prevention bodyweight modifies low-dose aspirin's effects on colorectal cancer (CRC) and major bleeding risk. We sought to investigate whether these effects are seen in patients with or without CVD in routine clinical practice ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.08.001

    authors： Cea Soriano L,Vora P,Soriano-Gabarró M,García Rodríguez LA

    更新日期：2019-12-15 00:00:00

  • Cardiovascular cavities cast in silicone rubber as an adjunct to post-mortem examination of the heart.

    abstract：:We used silicone rubber as a material for making post-mortem casts of cavities in 21 human hearts, 16 of them congenitally malformed, 13 after surgical reconstruction (Fontan and Norwood procedures) and 4 after reconstruction had been performed posts mortem for study purposes. The organs were either fresh, or had been...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(89)90141-1

    authors： Kilner PJ,Ho SY,Anderson RH

    更新日期：1989-01-01 00:00:00

  • Incidence and predictors of atrial fibrillation in a Chinese cohort of Brugada syndrome.

    abstract：BACKGROUND:Atrial electrophysiological abnormalities have previously been reported in Brugada syndrome. We investigated the incidence and electrocardiographic predictors of atrial fibrillation (AF) in a Chinese cohort of Brugada syndrome patients. METHODS:A retrospective study of Brugada syndrome patients admitted to ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.05.007

    authors： Tse G,Lee S,Mok NS,Liu T,Chang D

    更新日期：2020-09-01 00:00:00

  • Dissecting aneurysm of a right-sided descending aorta with a left-sided aortic arch.

    abstract：:A 66-year-old man presented with myocardial infarction. Chest X-ray showed a large mediastinal mass. Aortic dissection was suggested by a past history of chest trauma, but the mass was in a very atypical site. Dissection of an abnormally placed right-sided descending aorta was confirmed by computed tomography. The aor...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(88)90174-x

    authors： Oldroyd KG,Powell A,Carson P

    更新日期：1988-02-01 00:00:00

  • Effect of potassium supplementation on vascular function: A meta-analysis of randomized controlled trials.

    abstract：BACKGROUND:Effects of potassium supplementation on vascular function remain conflicting. This meta-analysis aimed to summarized current literature to fill the gaps in knowledge. METHODS:A literature search was performed on PubMed database through April, 2016. The measurements of vascular function included pulse wave v...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijcard.2016.10.119

    authors： Tang X,Wu B,Luo Y,Peng L,Chen Y,Zhu J,Peng C,Li S,Liu J

    更新日期：2017-02-01 00:00:00

  • The convergent procedure versus catheter ablation alone in longstanding persistent atrial fibrillation: A single centre, propensity-matched cohort study.

    abstract：BACKGROUND:Maintenance of sinus rhythm is challenging in patients with longstanding persistent atrial fibrillation (PeAF). Minimally invasive surgical AF ablation may improve outcomes when combined with catheter ablation (the 'convergent' procedure). This study evaluates the safety and efficacy of the convergent proced...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.10.053

    authors： Maclean E,Yap J,Saberwal B,Kolvekar S,Lim W,Wijesuriya N,Papageorgiou N,Dhillon G,Hunter RJ,Lowe M,Lambiase P,Chow A,Abbas H,Schilling R,Rowland E,Ahsan S

    更新日期：2020-03-15 00:00:00

  • Sex differences in clinical characteristics and inpatient outcomes among 2442 hospitalized Chinese patients with nonvalvular atrial fibrillation: The Nanchang Atrial Fibrillation Project.

    abstract：BACKGROUND:Limited data exists on the impact of sex on clinical characteristics and outcomes among nonvalvular AF patients from China. We investigated the impact of gender on risk factors and inpatient mortality in a hospitalized nonvalvular AF cohort in Nanchang, China. METHODS:We studied consecutive patients hospita...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2015.08.076

    authors： Xiong Q,Shantsila A,Lane DA,Zhou Q,Liu Y,Shen Y,Cheng X,Hong K,Lip GY

    更新日期：2015-12-15 00:00:00

  • Comparison of various methods for quantitative evaluation of myocardial infarct volume from magnetic resonance delayed enhancement data.

    abstract：BACKGROUND:Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) enables the estimation of myocardial infarct (MI) extent. Nevertheless, manual quantification is time consuming and subjective. We sought to assess MI volume with different quantitative methods in both acute (AMI) and chronic MI (CMI)....

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.03.056

    authors： Baron N,Kachenoura N,Cluzel P,Frouin F,Herment A,Grenier P,Montalescot G,Beygui F

    更新日期：2013-08-10 00:00:00

  • Impact of Fetuin-A on progression of calcific aortic valve stenosis - The COFRASA - GENERAC study.

    abstract：BACKGROUND:Aortic stenosis (AS) is an active disease, but the determinants of AS progression remain largely unknown. Low levels of Fetuin-A, a powerful inhibitor of ectopic calcification, have been linked to ectopic calcium tissue deposition but its role in AS progression has not been clearly evaluated. METHODS:In our...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2018.03.070

    authors： Kubota N,Testuz A,Boutten A,Robert T,Codogno I,Duval X,Tubiana S,Hekimian G,Arangalage D,Cimadevilla C,Kerneis C,Vahanian A,Messika-Zeitoun D

    更新日期：2018-08-15 00:00:00

  • Should general practitioners use the electrocardiogram to select patients with suspected heart failure for echocardiography?

    abstract：:Patient referrals from general practice for suspected heart failure are increasing the demand for echocardiograms, many of which are normal. We investigated whether general practitioners could be more selective by referring only patients with abnormal electrocardiograms for echocardiography. The electrocardiograms of ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(97)00181-2

    authors： Houghton AR,Sparrow NJ,Toms E,Cowley AJ

    更新日期：1997-10-31 00:00:00

  • Sex-related differences in peri- and post-ablation clinical data for patients with atrial flutter.

    abstract：UNLABELLED:Sex-related differences were not reported for the atrial flutter (AF). The purpose of the study was to look for the influence of gender on indications, clinical data and long-term results of AFl ablation. METHODS:985 patients, [227 females (23%)] were referred for radiofrequency AFl ablation. Clinical histo...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.12.088

    authors： Brembilla-Perrot B,Huttin O,Manenti V,Benichou M,Sellal JM,Zinzius PY,Beurrier D,Schwartz J,Laporte F,de Chillou C,Andronache M,Cismaru G,Pauriah M,Selton O,Louis P,Terrier de la Chaise A

    更新日期：2013-10-03 00:00:00

  • Takayasu arteritis evaluated by multi-slice computed tomography in an old man.

    abstract：:In the case of patients with Takayasu arteritis (TA), they consult a doctor for the first time when they have a slight fever, shoulder pain, chest pain, back pain, or headache, or when they are pointed out to have high CRP or anemia by chance in medical check-up. In TA, they are usually young women. In our case, the v...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.05.041

    authors： Fujita T,Ohtsuka M,Uchida E,Yamaguchi H,Nakajima T,Akazawa H,Takano H,Nakaya H,Komuro I

    更新日期：2008-04-10 00:00:00

  • Effect of intravenous and oral flecainide on ventricular tachycardia.

    abstract：:The effect of flecainide acetate, a class 1c antiarrhythmic agent, was examined in 15 patients with recurrent ventricular tachycardia. Intravenous flecainide was administered in a dose of 2 mg/kg at the time of intracardiac stimulation and recording studies. Oral flecainide was given to 10/15 patients and retesting wa...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(86)90007-0

    authors： Ward DE,Cheesman M,Dancy M

    更新日期：1986-03-01 00:00:00

  • The specificity of exercise electrocardiography in women grouped by estrogen status.

    abstract：:We compared the specificity of exercise electrocardiography in 1880 men and 1818 women with women grouped by menopausal and estrogen replacement status. Specificity for > or = 1 mm horizontal or downsloping ST-segment depression was determined using angiography in 781 patients and using two other nonangiography-based ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(97)02953-7

    authors： Morise AP,Beto R

    更新日期：1997-06-27 00:00:00

  • Reduced flow-mediated vasodilation of brachial artery in children with primary snoring.

    abstract：BACKGROUND:Sleep disordered breathing, especially obstructive sleep apnea, is associated with endothelial dysfunction in both adults and children. However, the role of primary snoring (PS) on endothelial function has not been investigated. This study aimed to examine flow-mediated vasodilation (FMD) in both normal weig...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.05.108

    authors： Li AM,Au CT,Chook P,Lam HS,Wing YK

    更新日期：2013-09-01 00:00:00

  • Protective effects of valsartan against cigarette smoke-induced left ventricular systolic dysfunction in rats.

    abstract：OBJECTIVES:To investigate the protective effects of valsartan against smoking-induced left ventricular dysfunction and explore the potential mechanisms involved. METHODS:Rats were randomly divided into 3 groups: smoking group (exposed to cigarette smoke), valsartan group (exposed to cigarette smoke and treated orally ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2012.03.068

    authors： Zhou X,Li C,Xu W,Chen J

    更新日期：2013-08-10 00:00:00