Abstract:
BACKGROUND:Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) enables the estimation of myocardial infarct (MI) extent. Nevertheless, manual quantification is time consuming and subjective. We sought to assess MI volume with different quantitative methods in both acute (AMI) and chronic MI (CMI). METHODS:CMR was performed 50 ± 21 h after MI in 52 patients and was repeated 100 ± 21 days later in a subgroup of 34 patients. Then, necrosis volumes were quantified using: 1) manual delineation, 2) automated fuzzy c-means method, and 3) +2 to 6 SD thresholding approaches. Results were compared against peak values of serum Troponin I (TnI), creatine kinase (CK) and left ventricular (LV) functional parameters: LV ejection fraction (LVEF), indexed end-diastolic (EDVi), end-systolic volumes (ESVi) and the number of hypokinetic segments (NbHk). RESULTS:For CMI, quantitative evaluation of infarct size using manual, +2SD, +3 SD and fuzzy c-means provided equivalent results in terms of correlation coefficients for comparisons of MI volumes against LV function parameters (LVEF: r>0.79, p<0.0001; ESVi: r>0.82, p<0.0001, EDVi: r>0.67, p<0.0001, NbHk: r>0.54, p<0.0009). For AMI, +2SD and fuzzy c-means approaches provided higher correlations for comparisons of AMI volumes against biochemical markers (CK: r>0.79, p<0.0001,TnI: r>0.77, p<0.0001) and chronic LV function parameters (LVEF: r>0.82, p<0.0001, NbHk: r>0.59, p<0.0002). CONCLUSIONS:The fuzzy c-means and 2SD methods provided highest correlations with biochemical MI quantification as well as LV function parameters. The fuzzy c-means approach which does not require an arbitrary identification of the remote myocardium is fast and reproducible. It may be clinically useful in the evaluation of patients with MI.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Baron N,Kachenoura N,Cluzel P,Frouin F,Herment A,Grenier P,Montalescot G,Beygui Fdoi
10.1016/j.ijcard.2012.03.056subject
Has Abstractpub_date
2013-08-10 00:00:00pages
739-44issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(12)00261-6journal_volume
167pub_type
杂志文章abstract:BACKGROUND:Cell adhesion molecules (CAM) play an important role in the pathogenesis of atherosclerosis by mediating the binding of leukocytes to the endothelium. Soluble CAM isoforms are known to be elevated in the sera of patients suffering from coronary artery disease (CAD). METHODS:We measured the concentrations of...
journal_title:International journal of cardiology
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doi:10.1016/j.ijcard.2005.01.042
更新日期:2006-01-13 00:00:00
abstract::A patient undergoing coronary artery bypass was found to have a giant epicardial lipoma weighing 1.36 kg which was excised uneventfully. The radiological and pathophysiological features are considered, and the options for management discussed. ...
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abstract::Matrix metalloproteinases are involved in the development of acute coronary syndromes, but they are not reliable clinical markers of the occurrence or the outcome of this syndrome. Many limitations in their assessment account for such failure. Functional genetic polymorphisms, as alternatives to plasma levels, might b...
journal_title:International journal of cardiology
pub_type: 评论,信件
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更新日期:2009-05-29 00:00:00
abstract:BACKGROUND:Conflicting data have been reported about the nature (physiologic versus pathologic) of left ventricular (LV) hypertrophy in master athletes. AIM OF THE STUDY:To analyze LV and right ventricular (RV) myocardial function in master athletes with LV hypertrophy induced by either endurance or strength training....
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.10.016
更新日期:2013-11-30 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(96)02730-1
更新日期:1996-09-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2007.07.003
更新日期:2008-07-04 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(00)00414-9
更新日期:2001-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0167-5273(00)00319-3
更新日期:2000-09-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.03.043
更新日期:2020-07-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.08.008
更新日期:2014-10-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1987-11-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.03.092
更新日期:2007-08-09 00:00:00
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pub_type: 杂志文章
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更新日期:1989-07-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.08.131
更新日期:2014-10-20 00:00:00
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journal_title:International journal of cardiology
pub_type: 评论,信件
doi:10.1016/j.ijcard.2008.11.110
更新日期:2010-07-09 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2021-01-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(93)90280-t
更新日期:1993-07-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
abstract::The effects of disopyramide on the atrial fibrillation threshold (AFT) in the human atrium were investigated. To evaluate atrial vulnerability, the following electrophysiologic parameters were measured before and after the administration of disopyramide (2 mg/kg) in 12 patients with paroxysmal atrial fibrillation: The...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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更新日期:1995-11-24 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2004-02-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2007-11-30 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.07.026
更新日期:2018-01-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.05.181
更新日期:2015-10-01 00:00:00