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Serum carboxy-terminal propeptide of type I procollagen (PIP) is a marker of diastolic dysfunction in patients with early type 2 diabetes mellitus.

Abstract：

:This study was designed to investigate whether the serum concentration of the carboxy-terminal propeptide of procollagen type I (PIP), a marker of myocardial fibrosis, is related to changes of the ventricular filling dynamics in patients with early type 2 diabetes mellitus (T2DM). The T2DM group had lower mitral and tricuspid E/A ratios than the control group. Serum PIP was higher in patients with T2DM than in controls (131.1+/-45.6 vs. 109.3+/-32.5 ng/mL, p=0.039). A-Ar, an estimate of passive diastolic function, was inversely related to serum PIP levels in T2DM (r=-0.42, p=0.03). These results show a relation between LV diastolic function and serum PIP levels in early T2DM.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Ihm SH,Youn HJ,Shin DI,Jang SW,Park CS,Kim PJ,Kim HY,Chang K,Seung KB,Kim JH,Choi KB

doi

10.1016/j.ijcard.2007.07.057

subject

Has Abstract

pub_date

2007-11-30 00:00:00

pages

e36-8

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(07)01548-3

journal_volume

122

pub_type

信件

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