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Yield of family screening in patients with isolated bicuspid aortic valve in a general hospital.

Abstract：

AIM:To determine the prevalence of unidentified bicuspid aortic valve (BAV) or aortic dilatation (>40mm) in first degree relatives (FDR) of patients with isolated BAV in a general hospital. METHODS AND RESULTS:Patients with isolated BAV received information advising cardiac screening of their FDR. Referred and screened were 134 FDR of 54 adult index patients with isolated BAV (median 2 per index patient). FDR's mean age was 49years (range 16-83years) and 41% were male. They comprised 5 parents (3.7%), 52 siblings (39%) and 77 offspring (57%). Among these FDR, the prevalence of BAV was 6.0% (8 patients). In FDR without BAV, 10 (7.5%) had aortic dilatation. 'Familial BAV' was present in 9/54 families (17%). CONCLUSION:In a general hospital, screening of FDR of patients with isolated BAV resulted in a substantial yield of 13% new cases with BAV or aortic dilatation without BAV.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Cozijnsen L,van der Zaag-Loonen HJ,Braam RL,Bakker-de Boo M,Post JG,Bouma BJ,Mulder BJM

doi

10.1016/j.ijcard.2017.12.046

subject

Has Abstract

pub_date

2018-03-15 00:00:00

pages

55-58

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(17)36977-2

journal_volume

255

pub_type

杂志文章

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