Abstract:
BACKGROUND:Exercise electrocardiography in asymptomatic adults has been criticized because of relatively poor accuracy predicting future heart disease risk, but studies may have been too short. We investigated if integrated analysis of graded exercise tolerance tests (GXT) predicted long-term coronary heart disease (CHD) and all-cause mortalities among community-dwelling older adults. METHODS AND RESULTS:From 1972 to 1974, 1789 adult residents of a predominantly Caucasian, middle- to upper-middle-class southern California community participated in a clinical evaluation that included a GXT; 52.4% (N=939) of those who had baseline GXT were followed up to 2010-up to 36years-for vital status, CHD and all-cause mortality. Multiply adjusted hazard ratios of an abnormal graded GXT were 1.65 (95% CI 0.78-3.49) and 1.56 (95% CI 1.15-2.11) for CHD and all-cause mortality, respectively. An integrated analysis hazard ratio was calculated based on the following GXT findings: significant ST change, inability to achieve target heart rate [THR], abnormal heart rate recovery [HRR], and chronotropic incompetency [ChI]. Compared to those with 0 or 1 abnormality, participants with 2 or more positive findings had significantly higher CHD (HR 2.18) and all-cause (HR 1.92) mortalities. Participants with 3 or more positive findings showed even higher hazard ratios-CHD (HR 6.16) and all-cause (HR 2.49) mortalities. When adjusted for any of 3 Framingham risk models, the integrated electrocardiographic model correlated well with CHD and all-cause mortalities. CONCLUSIONS:An integrated analysis of electrocardiographic and non-electrocardiographic measures of GXT is useful in predicting long-term CHD and all-cause mortalities in an asymptomatic middle-aged population.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Shin SY,Park JI,Park SK,Barrett-Connor Edoi
10.1016/j.ijcard.2014.12.026subject
Has Abstractpub_date
2015-02-15 00:00:00pages
323-7eissn
0167-5273issn
1874-1754pii
S0167-5273(14)02433-4journal_volume
181pub_type
杂志文章abstract:BACKGROUND:Adults with congenital heart disease (ACHD) are affected by atrial arrhythmias (AA). To elucidate the impact of AA on prognosis, we aimed to determine the impact of AA on death, heart failure and stroke in ACHD patients in a prospective nationwide clinical registry. METHODS:All patients aged ≥18years includ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.06.073
更新日期:2017-12-01 00:00:00
abstract::Most of the existing reports on abdominal compartment syndrome (ACS) deal with pathophysiology, focusing on its clinical picture and course, and knowledge of the histopathological features of ACS is very poor. Since the heart, kidneys and lungs are the organs primarily targeted for injury in multi-organ failure, we in...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.02.020
更新日期:2007-03-20 00:00:00
abstract:BACKGROUND:Therapeutic and prognostic implications of subclinical thyroid dysfunction in patients with heart failure (HF) are unclear. We compared the prognostic impact of euthyroidism, subclinical thyroid dysfunction, and euthyroid sick syndrome (ESS) in systolic HF. METHODS:We included 1032 patients hospitalized for...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2012.09.064
更新日期:2013-09-20 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia found in clinical practice. We combined high-resolution two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) to compare the atrial proteome of subjects with AF versus controls with sinus rhythm (SR). Our aim was to identify novel...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.04.036
更新日期:2011-08-04 00:00:00
abstract::In a series of 171 consecutive survivors of acute myocardial infarction, the predictive value of late potentials and QTc prolongation was prospectively assessed. QT intervals were measured in lead V2, corrected QT (QTc) was calculated using Bazett's equation (cut-off value 440 ms). Late potentials were considered to b...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(94)90032-9
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:The presence of small areas of necrosis has been occasionally reported immediately following apical ballooning syndrome (ABS). However, their persistence at later stages and impact on long-term prognosis are currently unknown. METHODS:Twenty consecutive patients admitted for ABS between 2004 and 2007 were p...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ijcard.2008.08.023
更新日期:2010-02-18 00:00:00
abstract::Coronary endothelial dysfunction has been demonstrated in patients with symptomatic heart failure. Furthermore the endothelium has been implicated in the pathogensis of cardiomyopathy in patients with normal coronary angiograms and no other known causes of heart failure. Herein we describe an asymptomatic patient with...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(95)02513-8
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:This retrospective analysis assessed the hypothesis that clinical status on admission more than other variables related to surgical or post-operative management may influence in-hospital mortality after surgical treatment of acute type A aortic dissection. METHODS:Between January 1979 and April 2004, 311 pa...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.03.013
更新日期:2007-02-14 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.11.069
更新日期:2007-11-30 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.11.004
更新日期:2006-10-26 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.04.181
更新日期:2014-07-01 00:00:00
abstract::Time-frequency maps of signal-averaged electrocardiogram based on a short time Fourier transform (STFT) technique analysis was employed to assess the presence of high frequency electrical transients (turbulence) and arrhythmia risk assessment. The optimal configuration set of STFT variables aiming at risk stratificati...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.04.013
更新日期:2010-11-05 00:00:00
abstract:BACKGROUND:Substance P (SP) may attenuate ischemia-reperfusion injury by reducing inflammation. We assessed cardioprotective effect of SP in a porcine model of acute myocardial infarction (AMI). METHODS:AMI was induced by occlusion of the left anterior descending artery on 28 swine, randomized to SP 5 nmol/kg (group 1...
journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2018-11-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(87)90035-0
更新日期:1987-10-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijcard.2016.08.176
更新日期:2016-11-15 00:00:00
abstract::Between 1977 and 1987, seven pregnant women (mean age 28 years) had closed mitral valvotomy through a left lateral thoracotomy during their first (3 cases), second (2 cases) or third (2 cases) trimester. Surgery was necessary either because of acute heart failure with pulmonary edema not responding to medical treatmen...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(90)90088-m
更新日期:1990-03-01 00:00:00
abstract:INTRODUCTION:Tissue Doppler imaging (TDI) and N-terminal-pro-Brain Natriuretic Peptide (NT-proBNP) provides useful non-invasive information about left ventricle filling pressures and both have demonstrated to be a prognostic marker in some valve disease as aortic stenosis (AS). OBJECTIVES:To assess the clinical value ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.11.144
更新日期:2017-02-01 00:00:00
abstract:INTRODUCTION:Current clinical practice guidelines recommend risk stratification in patients with acute coronary syndrome (ACS) upon admission to hospital. Diabetes mellitus (DM) is widely recognized as an independent predictor of mortality in these patients, although it is not included in the GRACE risk score. OBJECTI...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.06.083
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To assess the importance of an abnormal lipid profile as a risk factor in relation to non-biochemical risk factors, and to define the risk levels for lipid, lipoprotein and apolipoprotein in a Chinese population. PATIENTS AND METHODS:Serum lipids, lipoproteins, apolipoproteins and other cardiovascular risk f...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(93)90038-i
更新日期:1993-06-01 00:00:00
abstract::We have used cross-sectional real time color-coded Doppler echocardiography to characterize the patterns of the regurgitant jet seen in mitral valvar disease of different etiologies. We studied 118 patients with mitral regurgitation due to rheumatic valve disease (n = 26), hypertrophic obstructive cardiomyopathy (n = ...
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pub_type: 杂志文章
doi:10.1016/0167-5273(89)90252-0
更新日期:1989-05-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(83)90173-0
更新日期:1983-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.04.128
更新日期:2018-09-15 00:00:00
abstract:BACKGROUND:Pulmonary congestion is the main cause of hospital admission among heart failure (HF) patients. Lung ultrasound (LUS) assessment of B-lines has been recently proposed as a reliable and easy tool for evaluating pulmonary congestion. OBJECTIVE:To determine the prognostic value of LUS in predicting adverse eve...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.02.150
更新日期:2017-08-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.07.135
更新日期:2018-12-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-01-15 00:00:00
abstract::Over a 46-month period 181 pacemaker procedures were performed from an outpatient practice. Patients were admitted, operated on and discharged all within a 24-hour period. There were no pacemaker emergencies, major complications or emergency readmissions. The outpatient approach to permanent pacemaker procedures was n...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(87)90128-8
更新日期:1987-11-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2003.03.022
更新日期:2004-04-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.03.056
更新日期:2006-03-08 00:00:00
abstract:BACKGROUND:Existing trials almost exclusively used atenolol to represent the entire β-blocker class, and it is unknown whether there are intra-class differences. We compared the incidence of all-cause and cardiovascular mortality, blood pressure (BP) control and adherence levels between patients newly prescribed atenol...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.06.009
更新日期:2014-08-20 00:00:00