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Correlation of NT-proBNP with metabolic liver function as assessed with (13)C-methacetin breath test in patients with acute decompensated heart failure.

Abstract：

:Metabolic liver function is significantly decreased in patients with advanced chronic heart failure (CHF). The purpose of the study was to evaluate correlation of NT-proBNP with metabolic liver function as assessed with (13)C-methacetin breath test in patients with acute decompensation of chronic heart failure (ADHF). NT-proBNP, (13)C-methacetin breath test and investigation of other biochemical parameters were realized on days 0-2 (V1) and 2-7 (V2) after hospital admission in 13 consecutive ADHF patients. NT-proBNP and metabolic liver function as assessed with (13)C-methacetin breath test didn't change in the first days after hospital admission in ADHF patients. Correlation of NT-proBNP with the degree of metabolic liver function impairement was not significant. The study revealed significant correlation of NT-proBNP with serum ceruloplasmin and significant inverse correlation of liver function with total iron binding capacity in patients with ADHF. The results of this pilot study should be confirmed in a study with larger patient population.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Hendrichová M,Málek F,Kopřivová H,Vránová J,Ošťádal P,Krátká K,Sedláková M,Horák J

doi

10.1016/j.ijcard.2009.03.022

subject

Has Abstract

pub_date

2010-10-08 00:00:00

pages

321-2

issue

2

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(09)00282-4

journal_volume

144

pub_type

信件

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