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Animal models of organic heart valve disease.

Abstract：

:Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates in industrialized and developing countries. Animal models are interesting to investigate the causality, but also underlying mechanisms and potential treatments of human valvular diseases. Recently, animal models of heart valve disease have been developed, which allow to investigate the pathophysiology, and to follow the progression and the potential regression of disease with therapeutics over time. The present review provides an overview of animal models of primary, organic heart valve disease: myxoid age-related, infectious, drug-induced, degenerative calcified, and mechanically induced valvular heart disease.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Roosens B,Bala G,Droogmans S,Van Camp G,Breyne J,Cosyns B

doi

10.1016/j.ijcard.2012.03.065

subject

Has Abstract

pub_date

2013-05-25 00:00:00

pages

398-409

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(12)00270-7

journal_volume

165

pub_type

杂志文章,评审

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