Abstract:
:To determine the benefit of atrial contribution on work capacity in relation to left ventricular ejection fraction, we studied 17 patients (68 +/- 13 years) with dual chamber pacemakers (DDD) implanted for high degree atrioventricular (AV) block. In random order they were assigned to rate responsive ventricular (VVIR) and to atrial triggered ventricular (VDD) stimulation. Maximum oxygen uptake (max VO2), that correlates best with work capacity, was measured by spiroergometry at a respiratory quotient of 1.1 during treadmill exercise test. Left ventricular ejection fraction at rest was determined by radionuclide ventriculography during VDD-stimulation and an AV delay of 150 ms. There were no differences between these two pacing modes relating heart rate, blood pressure, minute ventilation, exercise duration and maximal work load. In eight patients with an ejection fraction > 50% (60 +/- 10%), but not in nine patients with an ejection fraction < 50% (41 +/- 10%), maximum oxygen uptake was significantly higher (P < 0.01) during atrial triggered ventricular pacing (1440 +/- 533 ml/min) compared with rate responsive ventricular pacing (1328 +/- 536 ml/min). Thus, rate responsive single chamber pacemakers largely enable the same work capacity as dual chamber pacemakers in patients with high degree AV block. Patients with normal left ventricular function may profit most from preserved AV synchrony as shown by the higher maximum oxygen uptake on exercise.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Frielingsdorf J,Dür P,Gerber AE,Vuilliomenet A,Bertel Odoi
10.1016/0167-5273(95)02308-jsubject
Has Abstractpub_date
1995-05-01 00:00:00pages
239-48issue
3eissn
0167-5273issn
1874-1754pii
016752739502308Jjournal_volume
49pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Bleeding following percutaneous coronary intervention (PCI) is common and may lead to transfusion and death. Although previous work has examined the effect of red blood cell (RBC) transfusion in patients with coronary disease, no study had investigated whether transfusion of non-RBC components was associated...
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pub_type: 临床试验,杂志文章,随机对照试验
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