Abstract：
OBJECTIVE:The effects of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) on dementia risk in patients with type 2 diabetes mellitus (DM) and hypertension remain unknown. We investigated the effects of ACEIs and ARBs on dementia risk in patients with type 2 DM and hypertension. METHODS:We conducted a cohort study by using the Taiwan National Health Insurance Research Database. We included 2377 patients receiving ACEIs and 1780 patients receiving ARBs in the ACEI and ARB cohorts, respectively. We included a comparable number of patients not receiving ACEIs and ARBs as controls in the non-ACEI and non-ARB cohorts through propensity score matching. The effect of ACEIs and ARBs on dementia risk was estimated through multivariate Cox proportional hazard regression after adjustment for several confounding factors. RESULTS:During the 12-year follow-up period, compared with the non-ACEI cohort, all-cause dementia risk decreased by 26% in the ACEI cohort [hazard ratio (HR)=0.74, 95% confidence interval (CI)=0.56-0.96]. The all-cause dementia risk was nearly 40% lower in the ARB cohort than in the non-ARB cohort (HR=0.60, 95% CI=0.37-0.97). These drugs prevented the occurrence of vascular dementia (VD), however, this effect was nonsignificant for Alzheimer's dementia (AD). Treatment duration- and dosage-related protection effects on dementia occurrence were observed. CONCLUSIONS:ACEIs and ARBs may effectively prevent all-cause dementia, particularly VD, in patients with type 2 DM and hypertension. Moreover, compared with ACEIs, ARBs appear to be more advantageous in dementia prevention.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Kuan YC,Huang KW,Yen DJ,Hu CJ,Lin CL,Kao CHdoi
10.1016/j.ijcard.2016.06.215subject
Has Abstractpub_date
2016-10-01 00:00:00pages
462-6eissn
0167-5273issn
1874-1754pii
S0167-5273(16)31221-9journal_volume
220pub_type
杂志文章abstract：:The bark powder of Terminalia arjuna, an indigenous plant has been found to have antianginal, decongestive and hypolipidemic effect. We planned a study to evaluate the role of T. arjuna in ischemic mitral regurgitation (IMR) following acute myocardial infarction (AMI). 40 patients with fresh AMI showing IMR were rando...
journal_title：International journal of cardiology
pub_type： 临床试验,信件,随机对照试验
doi：10.1016/j.ijcard.2004.10.045
更新日期：2005-04-28 00:00:00
abstract：:To test the hypothesis that neurotrophins might undergo significant changes in acute coronary syndrome (ACS), NGF and BDNF levels in sera of patients suffering of ACS and in control subjects were measured by enzyme-linked immunosorbent assay (ELISA). Plasma concentrations of glucose, total cholesterol, triglycerides, ...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2004.10.041
更新日期：2005-06-22 00:00:00
abstract：BACKGROUND:To compare magnetic resonance (MR) imaging and multidetector computed tomography (MDCT) for the assessment of myocardial infarction (MI) after alcohol septal ablation (ASA). METHODS:Ten patients (mean age, 60 years ± 16) were examined with both MDCT and 1.5-T MR imaging performed 10 minutes after injection,...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ijcard.2011.07.015
更新日期：2013-04-15 00:00:00
abstract：BACKGROUND:Existing trials almost exclusively used atenolol to represent the entire β-blocker class, and it is unknown whether there are intra-class differences. We compared the incidence of all-cause and cardiovascular mortality, blood pressure (BP) control and adherence levels between patients newly prescribed atenol...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.06.009
更新日期：2014-08-20 00:00:00
abstract：BACKGROUND:Late maternal mortality (up-to 1-year postpartum) is poorly reported globally and is commonly due to cardiovascular disease (CVD). We investigated targeted interventions aiming at reducing peripartum heart failure admission and late maternal death. METHODS AND RESULTS:Prospective single-centre study of 269 ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2018.07.140
更新日期：2018-12-01 00:00:00
abstract：INTRODUCTION:We conducted a meta-analysis of randomized, controlled trials of combined electrical stimulation versus conventional exercise training or placebo control in heart failure patients. METHODS:A systematic search was conducted of Medline (Ovid) (1950-September 2011), Embase.com (1974-September 2011), Cochrane...
journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ijcard.2011.12.019
更新日期：2013-07-15 00:00:00
abstract：BACKGROUND:Right parasternal view (RPV) is important in assessing the severity of aortic stenosis (AS). However, the feasibility and relevance of RPV in primary care is unresolved. Moreover, information regarding the role of RPV in the evaluation of the hemodynamic progression of AS is lacking. METHODS:Consecutive pat...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.04.091
更新日期：2017-08-01 00:00:00
abstract：:Coronary arterial disease in the cardiac allograft has emerged as the most serious long term complication of cardiac transplantation. The influence of patient-related and other potential risk factors on the development of coronary arterial disease at 1 year subsequent to cardiac transplantation was examined in 207 rec...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90043-o
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:Recent reports have provided evidence that bridging therapy with low-molecular-weight heparin (LMWH) may increase bleeding complications in patients with atrial fibrillation (AF) on oral anticoagulation undergoing percutaneous coronary intervention (PCI). We sought to assess mid-term bleeding and thromboembo...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2015.01.056
更新日期：2015-03-15 00:00:00
abstract：BACKGROUND:The effect of gout on the risk of developing coronary artery disease (CAD) is uncertain. Some studies have found that gout is a risk factor for acute myocardial infarction. This study examined the changes in risk of CAD in gout patients taking allopurinol and/or benzbromarone, and analyzed the dose-response ...
journal_title：International journal of cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ijcard.2017.02.013
更新日期：2017-04-15 00:00:00
abstract：:Takayasu arteritis, Buerger's diseases, temporal arteritis, vascular Behcet disease and inflammatory abdominal aortic aneurysm are classified in Japan as intractable vasculitides involving mainly large vessels, because their etiologies are not yet elucidated and, therefore, treatments for them were not yet established...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(00)00196-0
更新日期：2000-08-31 00:00:00
abstract：:A boy underwent total transcatheter occlusion of a patent arterial duct six years after successful balloon angioplasty of a native coarctation of the aorta. After successful implantation of a 12 mm device in the patent arterial duct there was no gradient across the descending aorta and five hours later there was no re...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(92)90066-c
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND:Myeloid differentiation factor-2 (MD-2) has been shown to be an important modulator of the innate immune system, but its role in cardiac diseases is unknown. We investigated whether MD-2 plays a role as risk predictor and contributor in dilated cardiomyopathy (DCM). METHODS AND RESULTS:We included 174 patie...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2018.06.025
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Progressive thinning and dilation of the LV due to ischemic heart failure (IHF) increases wall stress and myocardial oxygen consumption. Injectable biopolymers implanted in the myocardial wall have been used to increase wall thickness to reduce chamber volume, decrease wall stress, and improve cardiac functi...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.09.179
更新日期：2018-03-15 00:00:00
abstract：:Cardiovascular morbidity and mortality in patients with type 2 diabetes are a major problem in clinical practice. Thiazolidinediones (TZDs) are agonists of the peroxisome proliferator-activated receptor gamma which improve glycaemic control by reducing insulin resistance. TZDs also seem to have beneficial effects on v...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2008.06.005
更新日期：2009-01-24 00:00:00
abstract：:Cytokines are a large and rapidly expanding group of polypeptides produced by many different cell types. Increasing interest has been focused on the role of cytokines as mediators of metabolic, immunological and endocrine responses to surgery. The cytokine response in patients undergoing cardiac surgery during cardiop...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/0167-5273(96)02568-5
更新日期：1996-04-26 00:00:00
abstract：:Serial electrocardiograms as well as echocardiographic studies of 51 pilgrims suffering from acute heat stroke (mean rectal temperature 41.6 degrees C) were performed. All patients were examined immediately after cooling and 24 h later whenever possible. Regional wall motion abnormalities were detected in 9 cases (17....
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(92)90202-e
更新日期：1992-11-01 00:00:00
abstract：:We describe the first reported case of rupture of a pseudoaneurysm of a sapheneous vein coronary arterial bypass graft presenting with acute superior caval venous obstruction. The patient was successfully treated by urgent surgical excision of the graft. ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(89)90171-x
更新日期：1989-10-01 00:00:00
abstract：:Cardiac pacing from either endocardial or transesophageal sites has proven useful in termination of sustained supraventricular tachycardia in children. In two patients we demonstrated the efficacy of external pacing in the termination of sustained supraventricular tachycardia. The ease and apparent safety of the techn...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(90)90056-b
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:Recent evidence indicates that epicardial adipose tissue (EAT) expresses uncoupling protein-1 (UCP1), a marker of brown adipocytes. However, the putative effects of the presence of brown adipocytes in EAT remain unknown. METHODS:The mRNA expression of genes related to brown adipocyte-mediated thermogenesis ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2012.06.008
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Intuitively higher exercise program volume may be the primary stimulus for physical adaptation. We sought to establish if aerobic exercise training program characteristics produced different effect sizes for change in cardiorespiratory fitness in heart failure patients. METHODS:We conducted a MEDLINE search...
journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析
doi：10.1016/j.ijcard.2013.11.045
更新日期：2014-01-15 00:00:00
abstract：INTRODUCTION:Global left ventricular (LV) afterload as assessed by valvulo-arterial impedance (Zva), may be an independent predictor of mortality in patients with severe aortic stenosis (AS) and preserved LV ejection fraction (LVEF). However, its quantification using echocardiography may be subject to error measurement...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.11.180
更新日期：2015-02-01 00:00:00
abstract：AIM:To describe various factors associated with the very long-term prognosis for patients with a very small or an unconfirmed acute myocardial infarction (AMI).
METHODS:Patients below 76 years of age, hospitalized due to suspected AMI who either developed a very small AMI (enzyme elevation journal_title：International journal of cardiology pub_type： 杂志文章 doi：10.1016/s0167-5273(01)00383-7 更新日期：2001-05-01 00:00:00
abstract：BACKGROUND:Endothelial progenitor cells (EPCs) circulate in the adult peripheral blood and contribute to neovascularization. EPCs are considered to be included in CD34 positive mononuclear cells (CD34+ MNCs). Kinetics of circulating EPCs in congestive heart failure (CHF) has not been fully investigated. METHODS:We det...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2006.07.191
更新日期：2007-07-31 00:00:00
abstract：OBJECTIVE:Show how lunar catecholamine cardiomyopathy alone, exemplified by Neil Armstrong's single space walk, prior to exposure to inhalation of fine particulate matter, can trigger " Neil Armstrong Syndrome" or by Irwin with coronary, possibly hypertensive heart disease, and catecholamine cardiomyopathy. With space ...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2016.10.052
更新日期：2017-03-15 00:00:00
abstract：BACKGROUND:Intraventricular conduction disturbances are associated with an increased risk of adverse cardiovascular outcomes. However, data about factors associated with intraventricular conduction disturbances are sparse. We aimed to identify the clinical factors associated with intraventricular conduction disturbance...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.12.012
更新日期：2020-12-10 00:00:00
abstract：:Cross-sectional and Doppler echocardiographic characteristics of infective endocarditis are described in six cases following patch closure of a ventricular septal defect. The patients presented to us with fever one to five months after surgery. Five of them also had congestive cardiac failure. Cross-sectional echocard...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(89)90158-7
更新日期：1989-10-01 00:00:00
abstract：INTRODUCTION:Coronary artery ectasia (CAE) is defined as localized or diffuse dilatation of the epicardial coronary arteries. We sought to determine whether isolated CAE may alter P-wave duration and dispersion (PD). METHODS:The study population consisted of 26 patients (mean age: 61.6+/-11.0 years) with isolated CAE ...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.01.042
更新日期：2008-04-25 00:00:00
abstract：BACKGROUND:Insertable cardiac monitors (ICMs) are increasingly utilized for diagnosis of unexplained syncope and arrhythmia monitoring. The Reveal LINQ is a novel miniaturized ICM with improved algorithms. The feasibility and safety of insertion outside the traditional electrophysiology laboratory is unknown. Here we c...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.08.113
更新日期：2016-11-15 00:00:00
abstract：BACKGROUND:The aim of this large retrospective study was to provide a logistic risk model along an additive score to predict early mortality after surgical treatment of patients with heart valve or prosthesis infective endocarditis (IE). METHODS:From 2000 to 2015, 2715 patients with native valve endocarditis (NVE) or ...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2017.03.148
更新日期：2017-08-15 00:00:00
