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A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE.

Abstract：

BACKGROUND:The aim of this large retrospective study was to provide a logistic risk model along an additive score to predict early mortality after surgical treatment of patients with heart valve or prosthesis infective endocarditis (IE). METHODS:From 2000 to 2015, 2715 patients with native valve endocarditis (NVE) or prosthesis valve endocarditis (PVE) were operated on in 26 Italian Cardiac Surgery Centers. The relationship between early mortality and covariates was evaluated with logistic mixed effect models. Fixed effects are parameters associated with the entire population or with certain repeatable levels of experimental factors, while random effects are associated with individual experimental units (centers). RESULTS:Early mortality was 11.0% (298/2715); At mixed effect logistic regression the following variables were found associated with early mortality: age class, female gender, LVEF, preoperative shock, COPD, creatinine value above 2mg/dl, presence of abscess, number of treated valve/prosthesis (with respect to one treated valve/prosthesis) and the isolation of Staphylococcus aureus, Fungus spp., Pseudomonas Aeruginosa and other micro-organisms, while Streptococcus spp., Enterococcus spp. and other Staphylococci did not affect early mortality, as well as no micro-organisms isolation. LVEF was found linearly associated with outcomes while non-linear association between mortality and age was tested and the best model was found with a categorization into four classes (AUC=0.851). CONCLUSIONS:The following study provides a logistic risk model to predict early mortality in patients with heart valve or prosthesis infective endocarditis undergoing surgical treatment, called "The EndoSCORE".

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Di Mauro M,Dato GMA,Barili F,Gelsomino S,Santè P,Corte AD,Carrozza A,Ratta ED,Cugola D,Galletti L,Devotini R,Casabona R,Santini F,Salsano A,Scrofani R,Antona C,Botta L,Russo C,Mancuso S,Rinaldi M,De Vincentiis C,

doi

10.1016/j.ijcard.2017.03.148

subject

Has Abstract

pub_date

2017-08-15 00:00:00

pages

97-102

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(17)30987-7

journal_volume

241

pub_type

杂志文章,多中心研究

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A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE.