Abstract:
BACKGROUND:In general, women have lower risk for cardiovascular disease. We tested whether this sex-specific protection persists also in the presence of hypertensive left ventricular hypertrophy (LVH). METHODS:12,329 women and men with hypertension and free from prevalent cardiovascular disease enrolled in the prospective Campania Salute Network registry were followed over a median of 4.1years. Subjects were grouped according to the absence or the presence of LVH identified by echocardiography using validated sex-specific cut-off values of LV mass index (>47g/m2.7 in women and >50g/m2.7 in men). Main outcome was major cardiovascular events (MACE; combined acute coronary syndromes, stroke, hospitalization for heart failure and incident atrial fibrillation). RESULTS:The cardiovascular risk profile accompanying LVH did not differ between sexes, but presence of obesity and diabetes carried higher probability for LVH in women, and LVH was more prevalent in women than men (43.4 vs. 32.1%, p<0.001). Among patients without LVH (n=7764), women had a 35% lower hazard rate (HR) for MACE (n=179) than men (95% confidence interval [CI] 0.44-0.96, p=0.031) in Cox regression analysis adjusting for cardiovascular risk factors and antihypertensive treatment during follow up. In contrast, among patients with LVH (n=4565), women had a similar HR for MACE as men (HR 0.94 [95% CI 0.69-1.30], p=0.720). CONCLUSION:This study demonstrates that presence of LVH in hypertension offsets the female sex-protection in cardiovascular risk. Thus among hypertensive subjects with LVH, women and men have comparable cardiovascular risk.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Gerdts E,Izzo R,Mancusi C,Losi MA,Manzi MV,Canciello G,De Luca N,Trimarco B,de Simone Gdoi
10.1016/j.ijcard.2017.12.086subject
Has Abstractpub_date
2018-05-01 00:00:00pages
257-261eissn
0167-5273issn
1874-1754pii
S0167-5273(17)36165-Xjournal_volume
258pub_type
杂志文章abstract:BACKGROUND:Effects of potassium supplementation on vascular function remain conflicting. This meta-analysis aimed to summarized current literature to fill the gaps in knowledge. METHODS:A literature search was performed on PubMed database through April, 2016. The measurements of vascular function included pulse wave v...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
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更新日期:2017-02-01 00:00:00
abstract::Maintenance of normal potassium (K(+)) homeostasis has become an increasingly important limiting factor in the therapy of heart failure (HF). With the application of loop diuretics and digoxin, hypokalemia has become a frequent and feared side effect of treatment. Low serum K(+) in HF may be also a marker of increased...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
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更新日期:1992-03-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2015-10-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2006-08-10 00:00:00
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更新日期:2013-09-10 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-12-31 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2017-03-15 00:00:00
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更新日期:2011-05-19 00:00:00
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pub_type: 信件
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更新日期:2010-11-05 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.08.053
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0167-5273(94)90128-7
更新日期:1994-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-10-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2009-01-09 00:00:00
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pub_type: 杂志文章
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更新日期:2009-11-12 00:00:00
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pub_type: 杂志文章
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更新日期:2013-10-15 00:00:00
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pub_type: 信件
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更新日期:2018-12-01 00:00:00
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