当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Long-term active immunization with a synthetic peptide corresponding to the second extracellular loop of β1-adrenoceptor induces both morphological and functional cardiomyopathic changes in rats.

Long-term active immunization with a synthetic peptide corresponding to the second extracellular loop of β1-adrenoceptor induces both morphological and functional cardiomyopathic changes in rats.

Abstract：

BACKGROUND:β1-adrenoceptors (β1-ARs) are the predominant receptors in regulating heart functions. β1-ARs contain 7-transmembrane domains (7TM), 3 extracellular loops and 3 intracellular loops. Among these loops, the second extracellular loop of β1-AR (β1-AR-ECII) plays an important role in the pathogenesis of heart failure. METHODS:(1) Select the sera-negative rats for antibodies against β1-AR-ECII. (2) Detect the level of antibodies against β1-AR-ECII in the process of active immunization with artificial synthetic peptides according to the sequence of human β1-AR-ECII. (3) Observe its long-term role on cardiac structure and function in vivo by immunizing rats. (4) Detect the changes of T lymphocytes subsets in the process of active immunization. RESULTS:The peptides induced the production of specific autoantibody against β1-AR-ECII. Furthermore, immunization with β1-AR-ECII peptide induced both morphological and functional alterations in the hearts of rats, which potentially results in heart failure. In addition, induction of the autoantibodies against β1-AR-ECII increased the CD4+/CD8+ ratio in the peripheral blood of rats. DISCUSSION:In this study, we determined the effect of anti-β1-AR-ECII autoantibody on morphological and functional cardiomyopathic alterations by immunization of rats with a synthetic peptide corresponding to the β1-AR-ECII for 18 months. These results provide further evidence that autoantibody against β1-AR-ECII is involved in the pathogenesis of heart failure. But the underlying mechanisms need further study.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Zuo L,Bao H,Tian J,Wang X,Zhang S,He Z,Yan L,Zhao R,Ma XL,Liu H

doi

10.1016/j.ijcard.2009.12.023

subject

Has Abstract

pub_date

2011-05-19 00:00:00

pages

89-94

issue

1

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(09)01681-7

journal_volume

149

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CARDIOLOGY文献大全
  • Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9.

    abstract：BACKGROUND:Alterations in coronary vasomotor tone may participate in the pathogenesis of acute myocardial infarction (AMI). Vascular ATP-sensitive K(+) (KATP) channels, formed by Kir6.x/SUR2B, are key regulators of coronary tone and mutations in cardiac (Kir6.2/SUR2A) KATP channels result in heart disease. Here we expl...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2013.04.210

    authors： Smith KJ,Chadburn AJ,Adomaviciene A,Minoretti P,Vignali L,Emanuele E,Tammaro P

    更新日期：2013-10-09 00:00:00

  • Relationship of subclinical coronary atherosclerosis and National Cholesterol Education Panel guidelines in asymptomatic Brazilian men.

    abstract：BACKGROUND AND OBJECTIVE:Coronary heart disease (CHD) is the leading cause of death worldwide including Brazil. Improved precision in detecting early coronary disease may aid in more targeted preventive therapy. The National Cholesterol Education Program (NCEP) provides guidelines for determining the aggressiveness of ...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2005.04.008

    authors： Nasir K,Santos RD,Roguin A,Carvalho JA,Meneghello R,Blumenthal RS

    更新日期：2006-03-22 00:00:00

  • Prognostic value of myocardial scar by magnetic resonance imaging in patients undergoing coronary artery bypass graft.

    abstract：BACKGROUND:Previous studies demonstrated that scar tissue assessed by late gadolinium enhancement cardiovascular magnetic resonance imaging (LGE-CMR) is associated with recovery of cardiac function after coronary artery bypass graft (CABG) in patients with a history of myocardial infarction (MI). However, information o...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2020.10.052

    authors： Yang T,Lu M,Ouyang W,Li B,Yang Y,Zhao S,Sun H

    更新日期：2020-12-06 00:00:00

  • Which are the most reliable predictors of recurrence of atrial fibrillation after transcatheter ablation?: a meta-analysis.

    abstract：CONTEXT:Transcatheter ablation of atrial fibrillation (AF) has undergone important development, with acceptable midterm results in terms of the safety and recurrence. A meta-analysis was performed to identify the periprocedural complications, midterm success rates and predictors of recurrence after AF ablation. METHOD...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijcard.2012.05.008

    authors： D'Ascenzo F,Corleto A,Biondi-Zoccai G,Anselmino M,Ferraris F,di Biase L,Natale A,Hunter RJ,Schilling RJ,Miyazaki S,Tada H,Aonuma K,Yenn-Jiang L,Tao H,Ma C,Packer D,Hammill S,Gaita F

    更新日期：2013-09-01 00:00:00

  • A contemporary risk model for predicting 30-day mortality following percutaneous coronary intervention in England and Wales.

    abstract：BACKGROUND:The current risk model for percutaneous coronary intervention (PCI) in the UK is based on outcomes of patients treated in a different era of interventional cardiology. This study aimed to create a new model, based on a contemporary cohort of PCI treated patients, which would: predict 30 day mortality; provid...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.02.085

    authors： McAllister KS,Ludman PF,Hulme W,de Belder MA,Stables R,Chowdhary S,Mamas MA,Sperrin M,Buchan IE,British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research.

    更新日期：2016-05-01 00:00:00

  • Can the site of origin of ventricular extrasystoles enhance the localisation of exercise-induced ischaemia?

    abstract：:Previous work from the Departments of Cardiology and Nuclear Medicine, Guy's Hospital, London, has enabled an atlas of the electrocardiographic appearances of ectopics from individual ventricular sites to be compiled. This has been used to investigate the relationship between regions of myocardial ischaemia and the si...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(86)90143-9

    authors： Holt P,Brennand-Roper D,Curry PV,Maisey MN

    更新日期：1986-11-01 00:00:00

  • Effect of inhaled iloprost on the exercise function of Fontan patients: a demonstration of concept.

    abstract：BACKGROUND:Exercise capacity following Fontan surgery is often depressed. An inability to reduce pulmonary vascular resistance appropriately during exercise may contribute to this phenomenon. The aim of this study was to determine whether administration of iloprost, a selective pulmonary vasodilator, would improve exer...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijcard.2013.03.014

    authors： Rhodes J,Ubeda-Tikkanen A,Clair M,Fernandes SM,Graham DA,Milliren CE,Daly KP,Mullen MP,Landzberg MJ

    更新日期：2013-10-03 00:00:00

  • Increased prevalence of atrial fibrillation after the Great East Japan Earthquake: Results from the Fukushima Health Management Survey.

    abstract：BACKGROUND:Previous studies have shown that control of cardiovascular risk factors deteriorates among residents after a natural disaster. This study assessed the hypothesis that the prevalence of atrial fibrillation (AF) increased among residents in the evacuation zone of Fukushima prefecture after the Great East Japan...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2015.06.151

    authors： Suzuki H,Ohira T,Takeishi Y,Hosoya M,Yasumura S,Satoh H,Kawasaki Y,Takahashi A,Sakai A,Ohtsuru A,Kobashi G,Ozasa K,Yamashita S,Kamiya K,Abe M,Fukushima Health Management Survey Group.

    更新日期：2015-11-01 00:00:00

  • Diet and coronary arterial disease: a statistical study.

    abstract：:Statistical analysis comparing mortality rates from coronary arterial disease with food consumption in 21 countries belonging to the Organisation of Economic Cooperation and Development is presented. In a preliminary process correlation coefficients are calculated for coronary mortality and all food items appearing in...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/0167-5273(88)90262-8

    authors： Seely S

    更新日期：1988-08-01 00:00:00

  • The effectiveness of metoprolol versus atenolol on prevention of all-cause and cardiovascular mortality in a large Chinese population: a cohort study.

    abstract：BACKGROUND:Existing trials almost exclusively used atenolol to represent the entire β-blocker class, and it is unknown whether there are intra-class differences. We compared the incidence of all-cause and cardiovascular mortality, blood pressure (BP) control and adherence levels between patients newly prescribed atenol...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.06.009

    authors： Wong MC,Tam WW,Lao XQ,Wang HH,Kwan MW,Cheung CS,Tong EL,Cheung NT,Yan BP,Yu CM,Griffiths SM

    更新日期：2014-08-20 00:00:00

  • A comparison of HFrEF vs HFpEF's clinical workload and cost in the first year following hospitalization and enrollment in a disease management program.

    abstract：BACKGROUND:Admission with heart failure (HF) is a milestone in the progression of the disease, often resulting in higher intensity medical care and ensuing readmissions. Whilst there is evidence supporting enrolling patients in a heart failure disease management program (HF-DMP), not all reported HF-DMPs have systemati...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.12.057

    authors： Murphy TM,Waterhouse DF,James S,Casey C,Fitzgerald E,O'Connell E,Watson C,Gallagher J,Ledwidge M,McDonald K

    更新日期：2017-04-01 00:00:00

  • In vitro evaluation of vascular endothelial growth factor (VEGF)-eluting stents.

    abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a specific endothelial cell mitogen. It promotes re-endothelialisation of the damaged vessel surface seen after stenting. Stent thrombosis and in-stent restenosis are partly related to endothelial denudation caused by stent implantation. We propose using hydrocarb...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(03)00102-5

    authors： Swanson N,Hogrefe K,Javed Q,Gershlick AH

    更新日期：2003-12-01 00:00:00

  • No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure.

    abstract：BACKGROUND:Ghrelin, was observed to have treatment-potential for severe chronic heart failure (CHF) and cardiac cachexia based on anti-cachectic and cardio-protective effects. METHODS:We performed two studies to assess the effects of human ghrelin on food intake, body weight and body composition, as well as heart func...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2008.06.094

    authors： Akashi YJ,Palus S,Datta R,Halem H,Taylor JE,Thoene-Reineke C,Dong J,Thum T,Culler MD,Anker SD,Springer J

    更新日期：2009-11-12 00:00:00

  • Association between long-term prescription of metformin and the progression of heart failure with preserved ejection fraction in patients with type 2 diabetes mellitus and hypertension.

    abstract：BACKGROUND:Type 2 diabetes mellitus (T2DM) and hypertension are independently related to increasing risk of subsequent incident heart failure with preserved ejection fraction (HFpEF). This study was designed to evaluate the influences of long-term metformin prescription in these patients. METHODS:Using a propensity sc...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.11.087

    authors： Gu J,Yin ZF,Zhang JF,Wang CQ

    更新日期：2020-05-01 00:00:00

  • Sirolimus- vs. paclitaxel-eluting stents for the treatment of unprotected left main coronary artery stenosis: complete 2-year follow-up of a two-center registry.

    abstract：BACKGROUND:The feasibility of percutaneous coronary intervention (PCI) using drug-eluting stents and its comparability with bypass surgery in treatment of unprotected left main coronary artery (LMCA) stenosis has been shown previously. We compared the mid-to long-term outcome between sirolimus-(SES) vs. paclitaxel-elut...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2010.05.001

    authors： Park KW,Kang SH,Park KH,Choi DH,Lee HY,Kang HJ,Cho YS,Yeon TJ,Chung WY,Koo BK,Chae IH,Choi DJ,Oh BH,Park YB,Kim HS

    更新日期：2011-08-18 00:00:00

  • Sedentary behavior & health-related quality of life among congestive heart failure patients.

    abstract：BACKGROUND:Previous research demonstrates that participation in light-intensity physical activity (LIPA) and moderate-to-vigorous physical activity (MVPA) are favorably associated with health-related quality of life (HRQOL). Emerging work demonstrates that sedentary behavior (SB) is detrimentally associated with variou...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.06.256

    authors： Edwards MK,Loprinzi PD

    更新日期：2016-10-01 00:00:00

  • Could occupational physical activity mitigate the link between moderate kidney dysfunction and coronary heart disease?

    abstract：BACKGROUND:Chronic kidney disease is now regarded as a risk factor for cardiovascular disease. The impact of occupational or non-occupational physical activity (PA) on moderate decreases of renal function is uncertain. OBJECTIVES:We aimed to identify the potential association of PA (occupational and leisure-time) on e...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.09.102

    authors： Esquirol Y,Tully M,Ruidavets JB,Fogarty D,Ferrieres J,Quinn M,Hughes M,Kee F,Prime study.

    更新日期：2014-12-20 00:00:00

  • Clinical and echocardiographic predictors of left atrial clot and spontaneous echo contrast in patients with severe rheumatic mitral stenosis: a prospective study in 200 patients by transesophageal echocardiography.

    abstract：:The objective of this study was to prospectively investigate various clinical and echocardiographic variables to predict the left atrial and left atrial appendage clot and spontaneous echo contrast in patients with severe rheumatic mitral stenosis. We studied 200 consecutive patients (112 males and 88 females; mean ag...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(00)00235-7

    authors： Goswami KC,Yadav R,Rao MB,Bahl VK,Talwar KK,Manchanda SC

    更新日期：2000-05-31 00:00:00

  • Angioscopic comparison of arterial repair after second-generation drug-eluting stent implantation into vulnerable and stable coronary plaques.

    abstract：BACKGROUND:Arterial repair after intracoronary stenting depends on stent types and plaque vulnerability. The aim of this study was angioscopic comparison of arterial repair after implantation of the second-generation drug-eluting stents (G2-DES) between the stable and vulnerable plaques. METHODS:Four types of G2-DES w...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2016.07.089

    authors： Kawai K,Ichikawa M,Masuyama T,Kijima Y

    更新日期：2016-10-15 00:00:00

  • The impact of a 21-day ultra-endurance ride on the heart in young, adult and older adult recreational cyclists.

    abstract：BACKGROUND:This study assessed the acute effect of 21 days of challenging exercise on heart structure and function in recreationally active people across a range of age categories. METHODS:15 recreationally active people completed a 21-day fundraising cycling ride (MADRIDE) over a distance of 3515 km. Twenty-four hour...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2019.03.016

    authors： Wundersitz D,Williamson J,Nadurata V,Nolan K,Lavie C,Kingsley M

    更新日期：2019-07-01 00:00:00

  • Fasting insulin levels independently associated with coronary heart disease in non-diabetic Turkish men and women.

    abstract：BACKGROUND:Levels of plasma insulin have been recognized as a weak risk indicator for coronary or cardiovascular risk in the general population with ethnic background and gender modifying this relationship. We assessed whether insulin concentrations are associated with or would serve as a marker of prevalent coronary h...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(02)00190-0

    authors： Onat A,Ceyhan K,Sansoy V,Basar O,Erer B,Uysal O,Hergenç G

    更新日期：2002-11-01 00:00:00

  • Spontaneous coronary dissection complicating unstable coronary plaque in young women with acute coronary syndrome: case reports.

    abstract：:Spontaneous coronary artery dissection (SCAD) causing acute myocardial infarction is a rare event. It occurs mostly in young women without traditional risk factors for coronary artery disease, particularly during the peripartum period. We describe two occurrences of SCAD in young women in whom coronary atherosclerosis...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2005.12.021

    authors： Brunetti ND,Pellegrino PL,Mavilio G,Cuculo A,Ziccardi L,Correale M,Di Biase M

    更新日期：2007-01-31 00:00:00

  • Isoproterenol enhancement of I(Ks) current in amiodarone-induced long QT syndrome.

    abstract：:The response over time of the QT interval and the Transmural Dispersion of Repolarization (TDR) to Isoproterenol infusion (ISO) in an 85 year-old-man with severe and syntomatic bradycardia, in the setting of an Amiodarone-induced Long QT Syndrome (LQTS) is the subject of this communication. ISO shortened the QT and de...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2007.07.175

    authors： Raviña T,Raviña M,Gutierrez J

    更新日期：2009-04-17 00:00:00

  • Bivalirudin in percutaneous coronary intervention: the EUROpean BiValIrudin UtiliSatION in Practice (EUROVISION) Registry.

    abstract：PURPOSE:The prospective EUROVISION Registry was designed to capture patterns of use and short term outcomes in consecutive patients undergoing PCI with bivalirudin (BIV) in European centres. METHODS:A total of 2018 consecutive BIV-treated patients were included from 58 sites in 5 countries (Germany, Italy, France, Aus...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2014.03.003

    authors： Hamon M,Nienaber CA,Galli S,Huber K,Lipiecki J,Hill JM,Amabile N,Bernstein D,Deliargyris E,Lafont A,Steg PG

    更新日期：2014-05-01 00:00:00

  • Complex arrhythmias in Prinzmetal's angina reproduced by cold pressor test.

    abstract：:We describe the case of a young female patient with syncope due to complex arrhythmias associated with Prinzmetal's angina. The clinical situation was reproduced by the cold pressor test. ...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2008.12.076

    authors： Manolis AG,Akridas CC,Chatzis DG,Gerakios E,Dimopoulos C

    更新日期：2010-08-06 00:00:00

  • Aminoterminal propeptide of type III procollagen (PIIINP) is associated with ascending aortic aneurysm growth rate.

    abstract：UNLABELLED:Plasma levels of PIIINP a marker of extracellular matrix metabolism activity have been linked to abdominal aortic aneurysm growth rate, but its relationship with thoracic aortic aneurysm (TAA) growth has never previously been studied. OBJECTIVE:To demonstrate the value of assay of "aminoterminal propeptide ...

    journal_title：International journal of cardiology

    pub_type： 信件

    doi：10.1016/j.ijcard.2010.02.051

    authors： Ormezzano O,Baguet JP,Thony F,Blin D,Chavanon O,Toussaint B,Trocmé C,Vanzetto G,Faure P

    更新日期：2010-11-19 00:00:00

  • QT dispersion and autonomic nervous system function in patients with type 1 diabetes.

    abstract：:Cardiac arrhythmias and markedly increased mortality rate have been demonstrated in patients with diabetic autonomic neuropathy. Abnormal prolonged QT dispersion interval (QTd) is associated with a higher risk of ventricular arrhythmias. The aim of this study was to evaluate the relationship between autonomic dysfunct...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/s0167-5273(98)00091-6

    authors： Aytemir K,Aksöyek S,Ozer N,Gürlek A,Oto A

    更新日期：1998-06-01 00:00:00

  • Clinical presentation is the main predictor of in-hospital death for patients with acute type A aortic dissection admitted for surgical treatment: a 25 years experience.

    abstract：BACKGROUND:This retrospective analysis assessed the hypothesis that clinical status on admission more than other variables related to surgical or post-operative management may influence in-hospital mortality after surgical treatment of acute type A aortic dissection. METHODS:Between January 1979 and April 2004, 311 pa...

    journal_title：International journal of cardiology

    pub_type： 杂志文章

    doi：10.1016/j.ijcard.2006.03.013

    authors： Santini F,Montalbano G,Casali G,Messina A,Iafrancesco M,Luciani GB,Rossi A,Mazzucco A

    更新日期：2007-02-14 00:00:00

  • A systematic review and meta-analysis of multidetector computed tomography in the assessment of coronary artery bypass grafts.

    abstract：PURPOSE:The present meta-analysis aimed to compare the diagnostic accuracy of more recent computed tomography coronary angiography (CTCA) with invasive coronary angiography (ICA) in the assessment of graft patency after coronary artery bypass graft surgery (CABG). MATERIAL AND METHODS:A systematic review was performed...

    journal_title：International journal of cardiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijcard.2016.06.264

    authors： Chan M,Ridley L,Dunn DJ,Tian DH,Liou K,Ozdirik J,Cheruvu C,Cao C

    更新日期：2016-10-15 00:00:00

  • Effects of acetylstrophanthidin on baroreflex sensitivity in patients with acute myocardial infarction.

    abstract：:We evaluated the effects of acetylstrophanthidin on baroreflex sensitivity in patients soon after an acute myocardial infarction. Baroreflex control of heart rate is frequently depressed after acute myocardial infarction and few data are available as to the effects of pharmacological intervention on this parameter. Th...

    journal_title：International journal of cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0167-5273(93)90131-y

    authors： Bonaduce D,Petretta M,Morgano G,Bianchi V,Themistoclakis S,Rotondi F,Valva G,Carpinelli A

    更新日期：1993-08-01 00:00:00