Abstract:
BACKGROUND:Chronic kidney disease is now regarded as a risk factor for cardiovascular disease. The impact of occupational or non-occupational physical activity (PA) on moderate decreases of renal function is uncertain. OBJECTIVES:We aimed to identify the potential association of PA (occupational and leisure-time) on early decline of estimated glomerular filtration rate (eGFR) and to determine the potential mediating effect of PA on the relationship between eGFR and heart disease. METHODS:From the PRIME study analyses were conducted in 1058 employed men. Energy expended during leisure, work and commuting was calculated. Linear regression analyses were used to determine the link between types of PA and moderate decrements of eGFR determined with the KDIGO guideline at the baseline assessment. Cox proportional hazards analyses were used to explore the potential effect of PA on the relationship between eGFR and heart disease, ascertained during follow-up over 10 years. RESULTS:For these employed men, and after adjustment for known confounders of GFR change, more time spent sitting at work was associated with increased risk of moderate decline in kidney function, while carrying objects or being active at work was associated with decreased risk. In contrast, no significant link with leisure PA was apparent. No potential mediating effect of occupational PA was found for the relationship between eGFR and coronary heart disease. CONCLUSION:Occupational PA (potential modifiable factors) could provide a dual role on early impairment of renal function, without influence on the relationship between early decrease of e-GFR and CHD risk.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Esquirol Y,Tully M,Ruidavets JB,Fogarty D,Ferrieres J,Quinn M,Hughes M,Kee F,Prime study.doi
10.1016/j.ijcard.2014.09.102subject
Has Abstractpub_date
2014-12-20 00:00:00pages
1036-41issue
3eissn
0167-5273issn
1874-1754pii
S0167-5273(14)01822-1journal_volume
177pub_type
杂志文章abstract:BACKGROUND:Vascular Endothelial Growth Factor (VEGF) is an important angiogenesis factor involved in pathophysiology of cardiovascular diseases. Controlling this factor's level in the serum might have significant prognostic outcomes. METHODS:Twenty-four patients undergoing coronary artery bypass grafting were prospect...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.04.044
更新日期:2016-07-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.06.094
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.03.156
更新日期:2014-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2012.03.065
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.05.033
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2010-11-05 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2005-06-22 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:1996-10-11 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章
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