Abstract:
BACKGROUND:In the magnetic resonance T1-weighted imaging, some investigators have shown that coronary artery high-intensity signals (HISs) are associated with vulnerable plaque morphology and an increased risk of future cardiac events. Although previous studies used different PMR (the ratio between the signal intensities of coronary plaque and cardiac muscle) cutoff values to detect HIS, the association between PMR itself and plaque morphology has not been fully investigated. METHODS AND RESULTS:We prospectively investigated the association between PMR values and plaque morphology detected by optical coherence tomography in consecutive 106 patients with angina pectoris. The lesions with almost all of the vulnerable features such as lipid-rich, thin-cap fibroatheroma, plaque rupture, thrombus, macrophage infiltrations, intimal vasculature, and absence of calcification had significantly higher PMR; the only exception was the presence of cholesterol crystals. PMR increases linearly with the number of vulnerable features (p<0.0001, Rho=0.504). Stepwise multiple linear regression analysis revealed that the absence of calcification (p=0.0027), and the presence of thrombus (p=0.0071) and intimal vasculature (p=0.019) were independently associated with higher log-transformed PMR. There was a stepwise increase in PMR of the culprit lesions in proportion to the accumulation of the number of adverse plaque characteristics defined as non-calcified plaque, thrombus, and/or intimal vasculature. CONCLUSION:These results suggest that not only the presence of HIS, but also the elevated PMR itself may be used as a quantitative marker of plaque vulnerability in clinical evaluation.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Matsumoto K,Ehara S,Hasegawa T,Nishimura S,Shimada Kdoi
10.1016/j.ijcard.2016.12.028subject
Has Abstractpub_date
2017-03-15 00:00:00pages
284-286eissn
0167-5273issn
1874-1754pii
S0167-5273(16)32573-6journal_volume
231pub_type
杂志文章abstract:OBJECTIVES:To perform an analytical overview of the risk factors, pathogenesis of stroke and the strategies for the management of concomitant coronary artery disease and carotid artery stenosis (CAS). Four strategies were analysed; CABG in the presence of CAS, combined (CE+CABG), reverse (CABG+CE<3 months) and prior st...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/s0167-5273(00)00251-5
更新日期:2000-06-12 00:00:00
abstract::The incidence ratio of thyrotoxicosis among 14 patients with thyroid diseases associated with hypertrophic cardiomyopathy was compared with that in 7686 patients with thyroid diseases, to find the possible correlation between thyrotoxicosis and hypertrophic cardiomyopathy. Thyrotoxicosis did not predominate over other...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(86)90103-8
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:Periodontitis (PD) and type 2 diabetes (T2D) are characterized by increased mitochondrial oxidative stress production (mtROS), which has been associated with a greater risk of cardiovascular diseases (CVD). Intensive PD treatment (IPT) can significantly improve endothelial function and metabolic control, alt...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2018.05.019
更新日期:2018-11-15 00:00:00
abstract:BACKGROUND:To date, patients displaying stable angina with or without a previous acute coronary event have been grouped together and are offered nowadays, similar clinical approach. However, from clinical experience, increasing doubt exists whether they behave clinically in the same way. In the current study, we invest...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(03)00028-7
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:As advised by the European guidelines on cardiovascular prevention, medication intake is a major component of secondary prevention. The aim of this study is to provide an in-depth overview of the medication intake in stable European coronary heart disease (CHD) patients. METHODS:Analyses are based on the EU...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2019.09.015
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a feasible method to investigate the inflammatory activity of the myocardium in cardiac sarcoidosis. However, PET is costly and not as widely available as standard electrocardiogram (ECG). Current ECG findings related to cardiac sarcoidosis a...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.07.027
更新日期:2017-12-15 00:00:00
abstract::The mortality and morbidity were assessed during a 2-year follow-up in an acute intervention trial in suspected acute myocardial infarction with metoprolol (a selective beta 1-blocker). On admission to the trial, the 1395 participating patients were randomly allocated to metoprolol or placebo for 3 months. Thereafter,...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(86)90010-0
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:Heart rate variability and baroreceptor sensitivity are measures of autonomic control. While progestagen-containing replacement therapy in postmenopausal women adversely affects autonomic balance, the impact of hormonal contraceptives with synthetic progestagens on autonomic activity, neurohormones and C-rea...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.06.052
更新日期:2006-07-28 00:00:00
abstract:BACKGROUND:The pathogenesis of aortic valve stenosis may involve inflammation and we have previously demonstrated Chlamydophila pneumoniae (C. pneumoniae) DNA in stenotic aortic heart valves. Dissemination of these bacteria is probably mediated by alveolar macrophages. Bacterial DNA alone does not indicate whether the ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.01.052
更新日期:2010-08-06 00:00:00
abstract::A 73 year old woman, with previous history of coronary artery bypass grafting, was admitted for refractory unstable angina. The angiography revealed a significant stenosis of the ostium of the left subclavian artery. The patient underwent successful stenting of the subclavian artery and remained symptom free until hos...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.04.145
更新日期:2008-07-21 00:00:00
abstract:BACKGROUND:Thrombomodulin (TM) is the anticoagulant endothelial cell membrane-bound protein cofactor in the thrombin-mediated activation of protein C. Recently, conflicting data have been reported regarding the possible contribution of the TM -33G>A polymorphism to coronary artery disease (CAD) or myocardial infarction...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.05.007
更新日期:2005-04-28 00:00:00
abstract:BACKGROUND:Previous research demonstrates that participation in light-intensity physical activity (LIPA) and moderate-to-vigorous physical activity (MVPA) are favorably associated with health-related quality of life (HRQOL). Emerging work demonstrates that sedentary behavior (SB) is detrimentally associated with variou...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.06.256
更新日期:2016-10-01 00:00:00
abstract:BACKGROUNDS:Nitroglycerine-induced vasodilation (NID) is usually assessed as a control test for flow-mediated vasodilation (FMD). However, NID per se is impaired in patients with high cardiovascular risk. The purpose of this study was to investigate the associations of chronic kidney disease (CKD) with NID and FMD. ME...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.10.122
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The prognostic value of circulating oxidized low-density lipoprotein (OxLDL) in patients with unstable coronary artery disease (CAD) is unknown. METHODS:Plasma levels of OxLDL were measured in 433 patients with unstable CAD included in FRISC-II (Fragmin and fast Revascularisation in Instability in Coronary ...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ijcard.2005.11.006
更新日期:2006-11-10 00:00:00
abstract:BACKGROUND:Late maternal mortality (up-to 1-year postpartum) is poorly reported globally and is commonly due to cardiovascular disease (CVD). We investigated targeted interventions aiming at reducing peripartum heart failure admission and late maternal death. METHODS AND RESULTS:Prospective single-centre study of 269 ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.07.140
更新日期:2018-12-01 00:00:00
abstract::Only rarely have serious side effects been reported with the use of intravenous dipyridamole. We describe two cases of severe bradycardia, of which one led to asystole, in patients undergoing dipyridamole-thallium studies. The association between beta blocker therapy and the seven reported cases of asystole with dipyr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(93)90108-s
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is associated with death, end-stage renal disease, and heart failure in patients with coronary heart disease. This study investigated the association between AKI and long-term risk of stroke. METHODS AND RESULTS:50,244 patients who underwent coronary artery bypass grafting (CABG) i...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.08.049
更新日期:2013-10-15 00:00:00
abstract:BACKGROUND:In addition to standard therapy with ACE-inhibitors, digitalis and diuretics, beta-adrenergic receptor blockers have become a widely accepted strategy in the treatment of chronic heart failure. The role of calcium antagonists in CHF however remains controversial. To evaluate if a combination therapy of metop...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2008.02.022
更新日期:2009-02-20 00:00:00
abstract:BACKGROUND:Multiple studies have sought to determine variables associated with improved "response" to cardiac resynchronization therapy(CRT). Such variables, however, are often derived from inadequately controlled, single center cohort studies calling external validity into question. We sought to determine predictors o...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2016.09.078
更新日期:2016-12-15 00:00:00
abstract:BACKGROUND:The BASE ACS randomized trial demonstrated non-inferiority of titanium-nitride-oxide-coated bioactive stents (BAS), compared with everolimus-eluting stents (EES), for the primary endpoint of major adverse cardiac events (MACE) in patients presenting with acute coronary syndrome (ACS) at 12-month follow-up. W...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2016.07.267
更新日期:2016-11-01 00:00:00
abstract::Calcium channel blockers (CCBs) have several properties which may have beneficial effects on the development of atherosclerosis. These include inhibition of vascular smooth muscle cell (SMC) proliferation and migration; inhibition of calcium influx into the vascular wall; reduction of extracellular matrix synthesis; p...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/s0167-5273(97)00236-2
更新日期:1997-12-31 00:00:00
abstract:BACKGROUND:Platelets play a vital role in hemostasis and thrombosis. Catecholamines have a profound effect on platelet aggregation and atherothrombosis but the exact mechanism involved is insufficiently understood. In this report, we demonstrate the existence and role of alpha2B-adrenergic receptors (α2B-ARs) in normal...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2013.03.051
更新日期:2013-10-03 00:00:00
abstract::The imbalance of the autonomic nervous function has been shown to contribute to the genesis of ventricular arrhythmias. Power spectral analysis of components of heart rate variability has the potential to quantify the cardiac autonomic tone during ambulatory electrocardiographic recording. We analysed the power spectr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(93)90177-i
更新日期:1993-02-01 00:00:00
abstract::Plasma levels of human thioredoxin are indicative of the responses against oxidative stress. We measured the plasma thioredoxin levels in patients with unstable angina in order to examine the relationships between subsequent clinical course and plasma thioredoxin levels before and after treatment for unstable angina. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.01.010
更新日期:2005-03-18 00:00:00
abstract:OBJECTIVE:To examine a panel of 28 biomarkers for prediction of cardiovascular disease (CVD) and non-CVD mortality in a population-based cohort of men. METHODS:Starting in 1979, middle-aged men in Caerphilly underwent detailed medical examination. Subsequently 2171 men were re-examined during 1989-1993, and fasting bl...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2015.07.106
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:Congenital heart disease is one of the most common cardiac malformation-related diseases worldwide. Some causative genes have been identified but can explain only a small proportion of all cases; therefore, the discovery of novel susceptibility genes and/or modifier genes for abnormal cardiac development rem...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.05.029
更新日期:2020-09-01 00:00:00
abstract::Congenital left ventricular diverticulum is a rare cardiac malformation in an elderly patient. It frequently is associated with other cardiac or non-cardiac congenital malformations. We present an asymptomatic elderly patient, evaluated because of an incidental finding of a left ventricular anatomic change on chest co...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.04.106
更新日期:2008-04-10 00:00:00
abstract:BACKGROUND:It is unclear whether the cardiac mitochondrial dependent apoptotic pathways and Fas death receptor dependent apoptotic pathways will be induced by long-term intermittent hypoxia. METHODS:Twenty-seven Sprague-Dawley rats were randomly assigned into three groups: normoxia, long-term intermittent hypoxia (12%...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.03.064
更新日期:2007-04-04 00:00:00
abstract:BACKGROUND:Contrast-enhanced cardiac magnetic resonance imaging (MRI) can depict papillary muscle (PM) necrosis or fibrosis by late enhancement (LE) of PM, but its clinical significance in old myocardial infarction (OMI) has been little understood. METHODS:Myocardial LE and PM-LE were detected with contrast imaging in...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2010.04.037
更新日期:2011-01-07 00:00:00
abstract::Right ventricular infarction (RVI) occurs in approximately 50% of patients with inferior myocardial infarction (MI). The assessment of RVI is important for identifying patients being at increased risk of in hospital mortality and poorer prognosis if impaired right ventricular (RV) systolic function is present. We repo...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.05.047
更新日期:2008-07-21 00:00:00