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Angioscopic comparison of arterial repair after second-generation drug-eluting stent implantation into vulnerable and stable coronary plaques.

Abstract：

BACKGROUND:Arterial repair after intracoronary stenting depends on stent types and plaque vulnerability. The aim of this study was angioscopic comparison of arterial repair after implantation of the second-generation drug-eluting stents (G2-DES) between the stable and vulnerable plaques. METHODS:Four types of G2-DES were successfully implanted into stable plaques (n=41) and vulnerable plaques (n=34): 13 and 9 Xience-everolimus-, 7 and 6 Endeavor-zotarolimus-, 15 and 9 Resolute-zotarolimus-, and 6 and 10 Nobori-biolimus-eluting stents (EES, E-ZES, R-ZES, and BES), respectively. Coronary angioscopy at 1-year follow-up revealed in-stent appearance, such as neointimal stent coverage (NSC), presence of yellow plaques (YP), and in-stent mural thrombus (MT). NSC was graded into poor and good coverage. RESULTS:Yellow plaques and mural thrombi were found more frequently in the vulnerable plaques than in the stable plaques (29% vs. 12%, P=0.06; 12 vs. 0%, P=0.02; respectively). In EES, poor NSC was observed more frequently in the vulnerable plaques than in the stable plaques (54% vs. 11%, P=0.04). In BES, YP was observed more frequently in the vulnerable plaques than in the stable plaques (80% vs. 17%, P=0.01). In E-ZES and R-ZES, there were no significant differences with regards to angioscopic parameters between the stable and vulnerable plaques. CONCLUSIONS:Arterial repair after EES and BES implantation into the vulnerable plaques remained vulnerable even at 1-year follow-up.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Kawai K,Ichikawa M,Masuyama T,Kijima Y

doi

10.1016/j.ijcard.2016.07.089

subject

Has Abstract

pub_date

2016-10-15 00:00:00

pages

855-8

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(16)31444-9

journal_volume

221

pub_type

杂志文章

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