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Vasa vasoritis, vasculitis and atherosclerosis.

Abstract：

:Takayasu arteritis, Buerger's diseases, temporal arteritis, vascular Behcet disease and inflammatory abdominal aortic aneurysm are classified in Japan as intractable vasculitides involving mainly large vessels, because their etiologies are not yet elucidated and, therefore, treatments for them were not yet established. Recent experimental and vascular biological studies, however, have focussed on the roles of virus infection in vasa vasorum (vasa vasoritis) and on the subsequent inflammatory vascular changes through HLA and/or other autoimmune mechanisms. Several studies including ours have demonstrated that these vascular inflammatory changes progress from the adventitial side to the intimal side of the vessel, finally complicating atherosclerotic changes in the intima. These vascular inflammatory changes are also recognized during progression of atherosclerosis and these observations strongly suggest that inflammation is a serious risk factor of atherosclerosis.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Numano F

doi

10.1016/s0167-5273(00)00196-0

subject

Has Abstract

pub_date

2000-08-31 00:00:00

pages

S1-8; discussion S17-9

eissn

0167-5273

issn

1874-1754

pii

S0167527300001960

journal_volume

75 Suppl 1

pub_type

杂志文章

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