当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CARDIOLOGY期刊下所有文献 > Cardioprotective efficacy of sevoflurane vs. propofol during induction and/or maintenance in patients undergoing coronary artery revascularization surgery without pump: A randomized trial.

Cardioprotective efficacy of sevoflurane vs. propofol during induction and/or maintenance in patients undergoing coronary artery revascularization surgery without pump: A randomized trial.

Abstract：

PURPOSE:Pre and post-operative administration of sevoflurane in myocardial revascularization surgery provides enhanced cardioprotective effects exerted by pharmacologic pre- and post-conditioning, as compared to propofol. The identification of the enzymes involved in conditioning mechanisms is crucial to the understanding of the effects of sevoflurane in cardiac surgery patients. The impact of sevoflurane on another crucial target organ-the kidney-was also assessed. METHODS:Ninety patients undergoing off-pump myocardial revascularization surgery were allocated to receive either intra- and postoperative sevoflurane (SS), intraoperative sevoflurane and postoperative propofol (SP), or intra- and postoperative propofol (PP)). Troponin I and hemodynamic parameters were monitored during the first 48 postoperative hours; blood and urine samples were collected at baseline and at 24h to determine Akt, ERK1/2, PKG, iNO, bradykinin receptor, caspase 3, NT proBNP and urinary NGAL. RESULTS:The enzymes were overexpressed in the SS group, remained unchanged in the SP group, and decreased in the PP group. Renal function was best preserved in the SS group. CONCLUSIONS:The overexpression of enzymes induced by intraoperative anesthesia and postoperative sedation with sevoflurane reduces myocardial damage and improves renal function in patients undergoing off-pump myocardial revascularization surgery.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Guerrero Orriach JL,Galán Ortega M,Ramirez Fernandez A,Ramirez Aliaga M,Moreno Cortes MI,Ariza Villanueva D,Florez Vela A,Alcaide Torres J,Santiago Fernandez C,Matute Gonzalez E,Alsina Marcos E,Escalona Belmonte JJ,Rubio Navarro

doi

10.1016/j.ijcard.2017.04.105

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

73-80

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(17)30739-8

journal_volume

243

pub_type

杂志文章,随机对照试验

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