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Low serum potassium levels and diabetes - An unfavorable combination in patients with heart failure and preserved ejection fraction.

Abstract：

BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) is among the most common forms of heart failure (HF). We aimed to investigate the prognostic significance of serum potassium levels and its interaction with type-2 diabetes mellitus in patients with HFpEF. METHODS:Consecutive HFpEF patients were prospectively included in a registry study. The primary endpoint was a composite of cardiac death or HF hospitalization. RESULTS:363 HFpEF patients were enrolled (median age: 73.0 years; females: 70.3%). Median serum potassium (K+) was 4.3 mmol/L. A total of 128 (35.3%) patients had type-2 diabetes mellitus, of whom 92 were treated with oral anti-diabetic drugs and 35 with insulin. The study population was divided into two groups, according to their serum potassium levels. Significant differences between the groups were detected with regards to combined endpoint [n = 27 (61.4%) versus n = 87 (27.3%); p < 0.0001]. Lower serum potassium levels were significantly associated with adverse outcome in the Cox proportional hazard analysis [hazard ratio (HR): 1.83; 95% confidence interval (CI) 1.14-2.94; p = 0.0118]. Further independent predictors of adverse outcome were a history of HF hospitalizations (HR: 2.77; 95% CI 1.82-4.21; p < 0.0001), higher NT-pro BNP (HR: 1.93; 95% CI 1.82-4.21; p = 0.0084) as well as type-2 diabetes mellitus (HR: 1.57; 95% CI 1.05-2.34; p = 0.0027). Patients with diabetes and K+ ≤ 3.71 mmol/L faced the worst outcome as compared to the remainder of the group (p = 0.0001). CONCLUSION:In HFpEF patients, the combination of diabetes and low serum potassium levels are associated with an adverse outcome.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Badr Eslam R,Öztürk B,Panzer S,Qin H,Duca F,Binder C,Rettl R,Dachs TM,Alasti F,Vila G,Bonderman D

doi

10.1016/j.ijcard.2020.04.029

subject

Has Abstract

pub_date

2020-10-15 00:00:00

pages

121-127

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(20)30719-1

journal_volume

317

pub_type

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Low serum potassium levels and diabetes - An unfavorable combination in patients with heart failure and preserved ejection fraction.