Abstract:
BACKGROUND:The use of serum high-sensitivity C-reactive protein (hs-CRP) for cardiovascular risk profiling requires knowledge of the distribution in different populations. We studied serum hs-CRP in a healthy Brazilian population, with no evidence of heart disease, relative to gender and smoking status as well as other clinical and laboratory variables. METHODS:684 healthy Brazilian individuals, aged 14-74 years (mean 40.6 years), 295 men (43.1%) and 389 women (56.9%), were enrolled between July 1998 and July 2001. The relationship between the log-transformed hs-CRP, stratified by gender and smoking status (non-smokers, smokers), and clinical and laboratory variables were analyzed using the Spearman correlation coefficient and multiple linear regression. RESULTS:In a multiple linear regression model age (beta=1.0069, p=0.03), body mass index (BMI) (beta=1.0093, p<0.01), total cholesterol/HDL cholesterol ratio (TC/HDL-C) (beta=1.1015, p<0.01) and heart rate (beta=1.0139, p<0.01) were independently correlated with hs-CRP. Stratification according to gender and smoking was able to disclose different interactions between these variables and hs-CRP. Variables significantly correlated in each stratum were as follows: in smoker men, age (beta=1.0236, p=0.04) and TC/HDL-C (beta=1.2065, p<0.01); in non-smoker men, BMI (beta=1.0786, p<0.01) and TC/HDL-C (beta=1.1397, p=0.01); in smoker women, BMI (beta=1.1006, p=0.03); and in non-smoker women, BMI (beta=1.0873, p<0.01), TC/HDL-C (beta=1.1405, p=0.01) and heart rate (beta=1.0165, p=0.02). CONCLUSIONS:The clinical and laboratory variables studied influenced the concentration of hs-CRP according to gender and smoking. In assessing the risk of cardiovascular events in relation to serum hs-CRP level, stratification by gender and smoking status is indicated.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Araújo F,Pereira AC,Latorre Mdo R,Krieger JE,Mansur AJdoi
10.1016/j.ijcard.2003.10.027subject
Has Abstractpub_date
2004-12-01 00:00:00pages
433-8issue
3eissn
0167-5273issn
1874-1754pii
S0167527304000397journal_volume
97pub_type
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:To examine whether the recent flattening of mortality rates for coronary heart disease (CHD) observed among young adults in the UK and the US is also occurring in the Australian population. METHODS:Mortality data from 1976 to 2006 were used to calculate overall age-adjusted and age-specific mortality rates ...
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journal_title:International journal of cardiology
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 信件
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.06.122
更新日期:2013-09-10 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
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更新日期:1997-12-19 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2004.05.049
更新日期:2005-03-10 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of cardiology
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doi:10.1016/j.ijcard.2008.11.208
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1988-09-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2004.03.032
更新日期:2005-05-25 00:00:00
abstract:OBJECTIVES:Chronic kidney disease (CKD) is a risk factor for peripheral artery disease (PAD), but the impact of CKD in PAD patients who received endovascular treatment (EVT) is not well studied. Aim of this study is to clarify the impact of CKD in patients with PAD in real EVT era. METHODS:Using the Korean Vascular In...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2018-07-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.05.007
更新日期:2017-09-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijcard.2012.11.033
更新日期:2013-09-30 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2011.03.025
更新日期:2012-09-20 00:00:00
abstract:BACKGROUND:The Women's Health Study of Accra was conducted to determine the burden of illness in a representative sampling of adult urban women. METHODS:This community-based survey selected study participants by a 2-stage cluster probability sample stratified by socioeconomic status based on the 2000 Ghanaian census d...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2006.05.004
更新日期:2007-04-12 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.06.051
更新日期:2018-02-15 00:00:00
abstract::Streptokinase is an effective thrombolytic agent which, with early restoration of coronary blood flow, has the potential for limiting infarct size. Distinct from thrombolysis, we studied the effects of streptokinase on reperfusion coronary blood flow and infarct size. Open-chest anesthetized canines underwent a 90 min...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(89)90198-8
更新日期:1989-06-01 00:00:00