Five-year clinical outcomes in patients with significant coronary artery spasm: A propensity score-matched analysis.


BACKGROUND:Coronary artery spasm (CAS) is known to be a risk factor of acute coronary syndrome and angina pectoris. However, there is no currently available data with larger study population regarding long-term clinical outcomes of CAS in real world clinical practice. OBJECTIVES:We evaluated the prevalence of CAS and the impact of CAS on 5-year clinical outcomes in a series of Asian CAS patients documented by intracoronary acetylcholine (Ach) provocation test. METHODS:A total of 1413 consecutive patients without significant coronary artery disease (CAD) who underwent Ach provocation test between Nov. 2004 and Oct. 2008 were enrolled. Significant CAS was defined as >70% of narrowing by incremental intracoronary injection of 20, 50 and 100 μg. Patients were divided into two groups based on the presence of significant CAS (the non-CAS group: n=640, the CAS group; n=773). To adjust potential confounders, a propensity score matched (PSM) analysis was performed using the logistic regression model. RESULTS:A total of 54.7% (773/1413) patients were diagnosed as CAS documented by Ach provocation test. After PSM analysis, 2 propensity-matched groups (451 pairs, n=902, C-statistic=0.677) were generated. Despite of similar incidence of individual hard endpoints including mortality, myocardial infarction and revascularization, the CAS group showed the higher trend of recurrent angina requiring follow up angiography than the non-CAS group up to 5 years (HR; 1.56, 95% C.I.; 0.99-2.46, p=0.054). CONCLUSIONS:The prevalence of CAS was 54.7%. Although the cumulative incidence of recurrent angina requiring follow up coronary angiography seems to be increased up to 5 years in CAS patients, CAS patients was not associated with major individual and composite clinical outcomes such as mortality, MI, PCI, CVA with optimal medical therapy as compared with patients without CAS.


Int J Cardiol


Choi BG,Park SH,Rha SW,Park JY,Choi SY,Park Y,Xu S,Ngow HA,Ali J,Li H,Kim JB,Lee S,Na JO,Choi CU,Lim HE,Kim JW,Kim EJ,Park CG,Seo HS,Oh DJ




Has Abstract


2015-04-01 00:00:00












  • The Jing-Mai connections of the heart.

    abstract:BACKGROUND:The Jing-Mai (variously translated as the Channel, Vessel or Meridians), as described by traditional Chinese medicine, probably exists and has represented the connections between various parts of human body during embryonic development. According to the Chinese theories, there are 14 major Jing-Mai within th...

    journal_title:International journal of cardiology

    pub_type: 社论


    authors: Li-Ling J

    更新日期:2003-05-01 00:00:00

  • The association of Mediterranean diet with lower risk of acute coronary syndromes in hypertensive subjects.

    abstract:BACKGROUND:The elevation of blood pressure levels has been recognised as a determinant of the risk for several common cardiovascular diseases. In this work we examined the effect of Mediterranean type of diet on coronary risk in subjects with hypertension. METHODS:CARDIO2000 consisted of 848 randomly selected hospital...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Panagiotakos DB,Chrysohoou C,Pitsavos C,Tzioumis K,Papaioannou I,Stefanadis C,Toutouzas P

    更新日期:2002-02-01 00:00:00

  • Clinical utility of circulating interleukin-6 concentrations in the detection of functionally relevant coronary artery disease.

    abstract:BACKGROUND:Inflammation plays a major role in the pathogenesis of coronary artery disease (CAD). METHODS:We hypothesized, that quantifying inflammation by measuring circulating interleukin-6 concentrations help in the diagnosis and/or prediction of functionally relevant CAD. Among consecutive patients with symptoms su...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Walter J,Tanglay Y,du Fay de Lavallaz J,Strebel I,Boeddinghaus J,Twerenbold R,Doerflinger S,Puelacher C,Nestelberger T,Wussler D,Amrein M,Badertscher P,Todd J,Rentsch K,Fahrni G,Jeger R,Kaiser C,Reichlin T,Mueller C

    更新日期:2019-01-15 00:00:00

  • Intravenous iron sucrose reverses anemia-induced cardiac remodeling, prevents myocardial fibrosis, and improves cardiac function by attenuating oxidative/nitrosative stress and inflammation.

    abstract:BACKGROUND:According to recent clinical trial data, correction of iron deficiency with intravenous (i.v.) iron has favorable outcomes on cardiac function. We evaluated whether i.v. iron treatment of anemic rats has favorable effect on the left ventricular (LV) performance and remodeling and the role of oxidative/nitros...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Toblli JE,Cao G,Rivas C,Giani JF,Dominici FP

    更新日期:2016-06-01 00:00:00

  • Ticagrelor versus clopidogrel in patients undergoing implantation of paclitaxel-eluting stent in the femoropopliteal district: A randomized pilot study using frequency-domain optical coherence tomography.

    abstract:OBJECTIVES:Aim of this study was to evaluate different response in platelet reactivity and vessel healing using high-resolution frequency-domain optical coherence tomography (FD-OCT) in patients with femoropopliteal artery disease treated with ZILVER PTX drug eluting stents (DES), and randomly assigned to clopidogrel o...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ducci K,Liistro F,Porto I,Ventoruzzo G,Angioli P,Falsini G,Vergallo R,Bolognese L

    更新日期:2020-04-01 00:00:00

  • Comments on the article by Chen-Scarabelli and Scarabelli: history of medicine in the 'hidden world' and relevant articles in systematic reviews.

    abstract::When writing a review manuscript, choosing among potentially citable references is an arduous task. Decisions are commonly based on several aspects, ranging from obvious content relevance, passing through impact factor of the journal in which a prospective citable article was written, and reaching to sovereign persona...

    journal_title:International journal of cardiology

    pub_type: 评论,历史文章,信件


    authors: Benchimol-Barbosa PR

    更新日期:2009-08-14 00:00:00

  • The role of cytokines in cardiac surgery.

    abstract::Cytokines are a large and rapidly expanding group of polypeptides produced by many different cell types. Increasing interest has been focused on the role of cytokines as mediators of metabolic, immunological and endocrine responses to surgery. The cytokine response in patients undergoing cardiac surgery during cardiop...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Tønnesen E,Christensen VB,Toft P

    更新日期:1996-04-26 00:00:00

  • Clinical course and potential complications of small ventricular septal defects in adulthood: Late development of left ventricular dysfunction justifies lifelong care.

    abstract:BACKGROUND:Patients with small ventricular septal defects (VSDs) are thought to have excellent long-term survival, although complications may not be uncommon. METHODS:We identified all patients aged ≥ 16 years with native isolated VSD between January 2000 and September 2013. Clinical outcomes were retrospectively revi...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Karonis T,Scognamiglio G,Babu-Narayan SV,Montanaro C,Uebing A,Diller GP,Alonso-Gonzalez R,Swan L,Dimopoulos K,Gatzoulis MA,Li W

    更新日期:2016-04-01 00:00:00

  • Association of HLA DRB1-DQA1-DQB1 haplotypes with rheumatic heart disease in Taiwan.

    abstract::This case-control study was carried out to investigate the possible relationship between the gene frequencies of HLA-DRB1, -DQA1 and -DQB1 alleles/haplotypes and rheumatic heart disease (RHD) among the Chinese population in Taiwan. A group of 115 patients with RHD documented by echocardiography, and a group of 115 nor...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Chou HT,Chen CH,Chen JY,Chang KC

    更新日期:2008-08-29 00:00:00

  • Prognostic significance of quantitative assessment of focal myocardial fibrosis in patients with heart failure with preserved ejection fraction.

    abstract:BACKGROUND:The aim of this study was to investigate the prognostic value of myocardial focal fibrosis quantified by late gadolinium enhanced (LGE) magnetic resonance imaging (MRI) in patients with heart failure with preserved ejection fraction (HFpEF). METHODS:One-hundred eleven HFpEF patients (mean age: 70 ± 14 years...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Kato S,Saito N,Kirigaya H,Gyotoku D,Iinuma N,Kusakawa Y,Iguchi K,Nakachi T,Fukui K,Futaki M,Iwasawa T,Taguri M,Kimura K,Umemura S

    更新日期:2015-07-15 00:00:00

  • Excessive sinus pauses and their elimination in a patient with sleep apnea syndrome.

    abstract::A 40-year-old man with severe sleep apnoea syndrome presented significant sinus pauses during a 48 h electrocardiogram Holter recording. Holter analysis showed one sinus pause of 6.4 s duration, and many pauses greater than 3 s. The 48 h Holter reevaluation, after a continuous positive air pressure device was applied,...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Efremidis M,Sideris A,Kardaras F

    更新日期:1998-12-31 00:00:00

  • Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation.

    abstract:BACKGROUND:Mutations in SCN5A, the gene encoding the α-subunit of the cardiac sodium channel (NaV1.5), are associated with a broad spectrum of inherited cardiac arrhythmia disorders. The purpose of this study was to identify the genetic and functional determinants underlying a Dutch family that presented with a combine...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Lieve KV,Verkerk AO,Podliesna S,van der Werf C,Tanck MW,Hofman N,van Bergen PF,Beekman L,Bezzina CR,Wilde AAM,Lodder EM

    更新日期:2017-06-01 00:00:00

  • Coordinated proteomic signature changes in immune response and complement proteins in acute myocardial infarction: the implication of serum amyloid P-component.

    abstract:BACKGROUND:Patient outcomes after acute myocardial infarction (AMI) are influenced by the combined activation of several distinct interrelated signaling pathways. Specifically acute-phase response proteins can neutralize inflammatory agents, minimize the extent of tissue damage, and participate in tissue repair and reg...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Cubedo J,Padró T,Badimon L

    更新日期:2013-10-15 00:00:00

  • Intra-aortic balloon counterpulsation: variations in use and complications.

    abstract:OBJECTIVE:To study variations in use of intra-aortic balloon counterpulsation (IABC) and their impact on complications by comparing aspects of its use in a Regional Cardiothoracic Centre with an international database. METHODS AND RESULTS:Indications, technique and complication rate in 764 consecutive patients treated...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Azeem T,Stephens-Lloyd A,Spyt T,Hartshorne R,Gershlick AH

    更新日期:2004-04-01 00:00:00

  • Beneficial effects of smoking cessation on the short-term prognosis for variant angina--validation of the smoking status by urinary cotinine measurements.

    abstract::To examine whether smoking cessation would improve the short-term prognosis for patients with variant angina, 37 smokers with variant angina who were discharged after the complete disappearance of angina by medical treatment with calcium blockers were advised to stop smoking and were followed-up for 1 year. Urinary co...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Miwa K,Fujita M,Miyagi Y

    更新日期:1994-04-01 00:00:00

  • Sexual functioning and congenital heart disease: Something to worry about?

    abstract:BACKGROUND:Although sexual problems in cardiac patients are receiving increasing attention, research on sexual functioning of patients with congenital heart disease is very scarce. Therefore, this study investigated sexual functioning in adults with congenital heart disease and compared this with that of matched, healt...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Moons P,Van Deyk K,Marquet K,De Bleser L,Budts W,De Geest S

    更新日期:2007-09-14 00:00:00

  • Feasibility of single-beat full-volume capture real-time three-dimensional echocardiography for quantification of right ventricular volume: validation by cardiac magnetic resonance imaging.

    abstract:BACKGROUND:The lack of an accurate noninvasive method for assessing right ventricular (RV) volume and function has been a major deficiency of two-dimensional (2D) echocardiography. The aim of our study was to test the feasibility of single-beat full-volume capture with real-time three-dimensional echo (3DE) imaging sys...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Zhang QB,Sun JP,Gao RF,Lee AP,Feng YL,Liu XR,Sheng W,Liu F,Yang XS,Fang F,Yu CM

    更新日期:2013-10-09 00:00:00

  • Prognostic significance of left anterior fascicular block and its relation with coronary artery disease in old patients based on 570 autopsy cases.

    abstract:BACKGROUND:Left Anterior Fascicular Block (LAFB) occurs frequently among the elderly, and have a correlation with coronary artery disease (CAD), yet controversies regarding its clinical significance still remain. METHODS:We carried on a retrospective study involving 92 LAFB and 478 non-LAFB patients, in which anatomic...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ding S,Chai K,Li Y,Fang F,Yang J,Wang H

    更新日期:2018-10-15 00:00:00

  • Severe hypophosphataemia induced by glucose-insulin-potassium therapy. A case report and proposal for altered protocol.

    abstract::A case is described where severe hypophosphataemia was induced by a widely used protocol for glucose-insulin-potassium (GIK) infusion. Hypophosphataemia was found to be a universal sequel to the use of this infusion. A new regimen for administering this agent was designed, and shown to lack the potentially serious sid...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Marwick TH,Woodhouse SP

    更新日期:1988-03-01 00:00:00

  • Management and outcome of patients with acute myocardial infarction presenting with pacemaker rhythm.

    abstract:BACKGROUND:Diagnosis of acute myocardial infarction (MI) is challenging in pacemaker patients. Little is known about this patient group. METHODS:Patients with MI enrolled in the Swiss national AMIS Plus registry between January 2005 and December 2015 were analyzed. All patients with either paced ventricular rhythm or ...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Bertel N,Witassek F,Puhan M,Erne P,Rickli H,Naegeli B,Pedrazzini G,Stauffer JC,Radovanovic D

    更新日期:2017-03-01 00:00:00

  • Use of aspirin in conjunction with angiotensin-converting enzyme inhibitors does not worsen long-term survival in heart failure.

    abstract:BACKGROUND:A negative interaction has been shown to exist between aspirin and angiotensin-converting enzyme inhibitors (ACE-I) in subjects with heart failure. We explored the effect of combined ACE-I and aspirin therapy compared to ACE-I without aspirin on clinical outcomes in patients with heart failure. METHODS:430 ...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章


    authors: Harjai KJ,Solis S,Prasad A,Loupe J

    更新日期:2003-04-01 00:00:00

  • Right atrial free-floating thrombus in a patient with massive pulmonary embolism: a case of 'emboli in transit'.

    abstract::A 78-year-old man was admitted with sudden onset of dyspnea followed by syncope. Contrast-enhanced computed tomography showed embolism in the right main pulmonary artery and left upper pulmonary artery. Echocardiography revealed a large, free-floating thrombus and cine magnetic resonance imaging showed highly mobile, ...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Soga T,Sato Y,Matsumoto N,Tachibana E,Watanabe K,Kikushima K,Nagao K,Orime Y,Saito S,Hirayama A

    更新日期:2008-09-26 00:00:00

  • Cerebral haemorrhage in anticoagulated patients with non-septic mechanical valvular prosthesis.

    abstract::Cerebral haemorrhage in anticoagulated patients with mechanical valvular prosthesis poses an uncommon but difficult management problem. Four such patients are presented: one patient had delayed haemorrhagic transformation of a preexisting cerebral infarct, one probably had de novo haemorrhage complicating hypertension...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Lau CP,Chang CM,Lau GK,Wong CK,Fong PC,Yu YL

    更新日期:1991-03-01 00:00:00

  • Lvad pump speed increase is associated with increased peak exercise cardiac output and vo2, postponed anaerobic threshold and improved ventilatory efficiency.

    abstract:BACKGROUNDS:Peak exercise cardiac output (CO) increase is associated with an increase of peak oxygen uptake (VO2), provided that arteriovenous O2 difference [Δ(Ca-Cv)O2] does not decrease. At anaerobic threshold, VO2, is related to CO. We tested the hypothesis that, in heart failure (HF) patients with left ventricular ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Vignati C,Apostolo A,Cattadori G,Farina S,Del Torto A,Scuri S,Gerosa G,Bottio T,Tarzia V,Bejko J,Sisillo E,Nicoli F,Sciomer S,Alamanni F,Paolillo S,Agostoni P

    更新日期:2017-03-01 00:00:00

  • Provocation of supraventricular tachycardias by an intravenous class I antiarrhythmic drug.

    abstract::Antiarrhythmic drugs may aggravate or induce ventricular arrhythmia. The induction of a supraventricular tachycardia or its facilitation has rarely been reported. The purpose of the study was to know whether the potential for supraventricular proarrhythmic effect of a class Ia intravenous antiarrhythmic drug can be ex...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Brembilla-Perrot B,Terrier de la Chaise A

    更新日期:1992-02-01 00:00:00

  • Interatrial block and cognitive impairment in the BAYES prospective registry.

    abstract:BACKGROUND:An association between interatrial block (IAB) (P wave duration ≥120 ms) and dementia has been suggested. Our objective was to assess the association of IAB with cognitive impairment (CI). METHODS:The prospective BAYES registry included 552 patients ≥70 years with structural heart disease without documented...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Martínez-Sellés M,Martínez-Larrú ME,Ibarrola M,Santos A,Díez-Villanueva P,Bayés-Genis A,Baranchuk A,Bayés-de-Luna A,Elosua R

    更新日期:2020-12-15 00:00:00

  • Platelet reactivity and clopidogrel resistance are associated with the H2 haplotype of the P2Y12-ADP receptor gene.

    abstract:BACKGROUND:Platelet hyperreactivity was reported in clopidogrel-naiotave carriers of the H2 haplotype of the P2Y(12) platelet ADP receptor. Here, we studied the influence of this genetic variant on clopidogrel responsiveness. METHODS:ADP-mediated (5 micromol/L) platelet aggregation was determined by impedance (Omega) ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Staritz P,Kurz K,Stoll M,Giannitsis E,Katus HA,Ivandic BT

    更新日期:2009-04-17 00:00:00

  • Renal response to intravascular volume expansion in euvolemic heart failure patients with reduced ejection fraction: Mechanistic insights and clinical implications.

    abstract:BACKGROUND:Untreated and preclinical heart failure patients with reduced ejection fraction (HFrEF) have an impaired ability to alleviate excess intravascular volume. OBJECTIVES:To investigate 1) the renal response to intravascular volume expansion in euvolemic and optimally treated HFrEF patients and 2) loop diuretic ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Nijst P,Verbrugge FH,Martens P,Dupont M,Tang WHW,Mullens W

    更新日期:2017-09-15 00:00:00

  • Effects of a stable prostacyclin analogue beraprost sodium on VEGF and PAI-1 gene expression in vascular smooth muscle cells.

    abstract:BACKGROUND:Beraprost sodium, an orally active prostacyclin analogue, has proved to be beneficial for the patients with primary pulmonary hypertension and obstructive peripheral arterial disease. METHODS:In this study, we examined the effects of BPS on the expression of the VEGF and PAI-1 genes in vascular smooth muscl...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Atsuta H,Uchiyama T,Kanai H,Iso T,Tanaka T,Suga T,Maeno T,Arai M,Nagai R,Kurabayashi M

    更新日期:2009-03-06 00:00:00

  • Initial real world experience with a novel insertable (Reveal LinQ(@Medtronic)) compared to the conventional (Reveal XT(@Medtronic)) implantable loop recorder at a tertiary care center - Points to ponder!

    abstract:INTRODUCTION:Limited data is available regarding the novel Reveal LinQ (LinQ) which is a new generation implantable loop recorders (ILRs). METHODS:We performed a prospective, observational study of all consecutive patients undergoing conventional (Reveal XT; XT) and LinQ devices at our institution between January 2012...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Gunda S,Reddy YM,Pillarisetti J,Koripalli S,Jeffery C,Swope J,Atkins D,Bommana S,Emert MP,Pimentel R,Dendi R,Berenbom LD,DiBiase L,Natale A,Lakkireddy D

    更新日期:2015-07-15 00:00:00