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Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease.

Abstract：

BACKGROUND:The objective of this prospective study was to assess the efficacy of exercise training as add-on to medical therapy in patients with congenital heart disease associated pulmonary arterial hypertension (CHD-APAH). METHODS:Patients with invasively confirmed CHD-APAH received in-hospital exercise training for 3 weeks and continued at home. Efficacy parameters were evaluated at baseline, after 3 and 15 weeks. Medical treatment remained unchanged. Worsening events and survival rate were assessed in a follow-up period of 21 ± 14 months. RESULTS:Twenty consecutive CHD-APAH patients (16 female, 4 male, mean pulmonary arterial pressure 60 ± 23 mm Hg) were included. Patients significantly improved the mean distance walked in 6 min compared to baseline by 63 ± 47 m after 3 weeks (p<0.001) and by 67 ± 59 m after 15 weeks (p=0.001). Quality of life-score (p=0.05), peak oxygen consumption (p=0.002) and maximal workload (p=0.003) improved significantly by exercise training after 15 weeks. The 1- and 2-year survival rates were 100%, the transplantation-free survival rate was 100% after 1 year and 93% after 2 years. CONCLUSION:Exercise training as add-on to medical therapy may be effective in patients with CHD-APAH and improved work capacity, quality of life and further prognostic relevant parameters. It was associated with an excellent long-term survival. Further randomized controlled studies are needed to confirm these results.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Becker-Grünig T,Klose H,Ehlken N,Lichtblau M,Nagel C,Fischer C,Gorenflo M,Tiede H,Schranz D,Hager A,Kaemmerer H,Miera O,Ulrich S,Speich R,Uiker S,Grünig E

doi

10.1016/j.ijcard.2012.09.036

subject

Has Abstract

pub_date

2013-09-20 00:00:00

pages

375-81

issue

1

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(12)01142-4

journal_volume

168

pub_type

杂志文章

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