Abstract:
UNLABELLED:Increased QT dispersion, defined as the difference between the maximum and minimum QT interval on the standard 12-lead electrocardiogram is assumed to reflect regional inhomogeneity of ventricular repolarization and has been shown to be associated with an increased risk of arrhythmic events. The purpose of the present study is to examine the influence of amiodarone on QT dispersion in patients with life-threatening ventricular arrhythmias and to evaluate the predictive value of QT dispersion after amiodarone therapy for further arrhythmic events. ECG's were obtained in 47 patients 1-2 days before and 6-8 weeks after amiodarone was started. All patients had coronary artery disease with a mean EF of 34 +/- 14%. The QT interval was measured in each lead of a digitized ECG displayed on a high resolution monitor (250 mm s-1). Amiodarone therapy resulted in a significant increase in the maximal QTc interval (476 +/- 44 to 505 +/- 44 ms, p < 0.001). However, measurement of QT dispersion (70 +/- 34 vs 73 +/- 29 ms) and Qtc dispersion (78 +/- 37 vs 77 +/- 31 ms) revealed no significant difference before and after amiodarone. During a one year follow-up period 26 patients were free of arrhythmic events and 7 patients developed further arrhythmic events. The remaining 14 patients were excluded from the one year follow-up analysis because of drug discontinuation (n = 8), death due to heart failure (n = 1), medical intervention (n = 3) and incomplete follow-up (n = 2). No measure of QT dispersion was predictive of recurrent arrhythmic events during treatment with amiodarone. CONCLUSION:Treatment with amiodarone results in significant QT prolongation without altering QT dispersion. Measurements of QT dispersion were not predictive of amiodarone efficacy in this patient population.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Meierhenrich R,Helguera ME,Kidwell GA,Tebbe Udoi
10.1016/s0167-5273(97)00073-9subject
Has Abstractpub_date
1997-08-08 00:00:00pages
289-94issue
3eissn
0167-5273issn
1874-1754pii
S0167527397000739journal_volume
60pub_type
临床试验,杂志文章,随机对照试验abstract::We studied the acute and long-term effects of ramipril and captopril in 12 patients with moderate to severe congestive heart failure using an open, parallel design. Drug doses were titrated. Compared with baseline values, maximal haemodynamic and humoral effects after the first dose of both angiotensin converting enzy...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(89)90330-6
更新日期:1989-04-01 00:00:00
abstract::Eighty patients underwent percutaneous transluminal coronary angioplasty (PTCA) for 109 lesions. Comparison was done between two groups based on balloon compliance. The groups were comparable in their baseline characteristics. The mean inflation pressure used with compliant balloons was significantly higher; other pro...
journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:In this prospective study we evaluated the relationship between thromboxane B2 (TXB2), prostacyclin (PGI2) and lactate concentrations, and the improvement of walking abilities and endothelial function in patients with peripheral artery disease (PAD) undergoing a supervised treadmill training program (STTP). ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.07.274
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Previous research demonstrates that participation in light-intensity physical activity (LIPA) and moderate-to-vigorous physical activity (MVPA) are favorably associated with health-related quality of life (HRQOL). Emerging work demonstrates that sedentary behavior (SB) is detrimentally associated with variou...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.06.256
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.07.038
更新日期:2017-12-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2001-12-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2003.10.014
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Despite frequent life-long hemodynamic and electrophysiologic abnormalities, adults with congenital heart defects (CHDs) are often lost to medical follow-up. Using a cohort of adults with CHD receiving hospital care in Arkansas, we sought to determine how often a CHD is recognized and coded during hospital a...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.02.100
更新日期:2017-05-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(93)90038-i
更新日期:1993-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2008-07-21 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.08.057
更新日期:2014-10-20 00:00:00
abstract::In-stent Restenosis (ISR) is the Achilles heel for using of stent. Vascular brachytherapy (VBT) has been the principal scientifically investigated local therapy for coronary artery ISR. In our suggested method, a new type of stent, which is coated with Boron ((10)B) compound, is used. The coating layer of the stent co...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.04.036
更新日期:2009-08-14 00:00:00
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journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ijcard.2011.01.044
更新日期:2012-07-26 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.06.007
更新日期:2013-09-10 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.02.015
更新日期:2016-04-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.05.029
更新日期:2020-09-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
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更新日期:2013-10-12 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.10.017
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.07.015
更新日期:2006-04-28 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:1984-06-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章,评审
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更新日期:1998-10-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 信件
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更新日期:2008-04-25 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2012.03.068
更新日期:2013-08-10 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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更新日期:2016-02-15 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
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journal_title:International journal of cardiology
pub_type: 信件,评审
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(92)90055-8
更新日期:1992-04-01 00:00:00
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journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(00)00179-0
更新日期:2000-08-31 00:00:00